Prevalence of irregular red blood cell antibodies among healthy blood donors in Delhi population

Garg, Neeraj; Sharma, Tanya; Singh, Bharat

doi:10.1016/j.transci.2014.03.004

Cited by 28 publications

(36 citation statements)

References 7 publications

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“…The prevalence noted in the present study is 0.09%, which is comparable with the similar two studies conducted from the same region. [ 7 8 ] Pahuja et al . [ 7 ] showed the prevalence of 0.05% among 7756 whole blood donors.…”

Section: Discussionmentioning

confidence: 99%

“…Garg et al . [ 8 ] reported a prevalence of 0.09% among 47,450 whole blood donors. On the contrary, Giblett[ 9 ] had reported 0.32% incidence of irregular RBC antibodies in blood donors.…”

Section: Discussionmentioning

confidence: 99%

“…In another study, Garg et al . [ 8 ] performed on 47,065 whole blood donors found 0.09% prevalence of irregular red cell antibody.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of irregular red cell antibody in healthy blood donors attending a tertiary care hospital in North India

Makroo

Rajput

Agarwal

et al. 2018

Asian J Transfus Sci

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BACKGROUND:Alloantibodies may be detected in blood donors who have either been transfused previously or female donors with previous obstetric events. These antibodies can occasionally cause severe transfusion reaction, if a large amount of plasma or whole blood is transfused, as in massive transfusions and pediatric patients.AIMS:The present study aims to assess the prevalence of red cell antibodies in healthy blood donors at a tertiary care hospital-based blood bank in India.MATERIALS AND METHODS:A total of 82,153 donor samples were screened for irregular red cell antibodies between January 2012 and December 2015 at the Department of Transfusion Medicine, Indraprastha Apollo Hospitals, New Delhi. Antibody screening was performed by solid phase method using Immucor Capture–R ready screen (pooled cells) on fully automated immunohematology analyzer Galileo Neo (Immucor Inc., Norcross, GA, USA). Positive tests were further confirmed using Capture-R ready screen (4 cell panel). Advanced investigations to identify the antibody/ies were performed on confirmed positive samples. Antibody identification was conducted using various cell panels (Immucor Capture-R Ready-ID, Panocell-10, Ficin Treated). An advanced technique such as adsorption and elution was performed as per requirement.RESULTS:Screening with pooled cells and 4 cell panel was positive in 227 donors (0.27%), 150 of these donors had autoantibodies, 1 had autoantibodies with underlying alloantibody anti-Jka (0.001%), and 76 had alloantibodies (0.09%) alone in their plasma. Anti-M was the most common antibody (43 donors) identified, followed by anti-D (21 donors). Anti-N was detected in 4; anti-Jka, anti-C, and anti-E in two donors each followed by anti-P1 and anti-Leb in 1 donor.CONCLUSION:Antibodies against red cells can be present in healthy donors detection of which is important in providing safe blood to the patient. The prevalence of red blood cell antibody in healthy donors in this study was found to be 0.27%, while the prevalence of alloantibodies was 0.09%. The majority of alloantibodies were anti-M (56.57%) and anti-D (27.63%).

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Section: Discussionmentioning

confidence: 99%

“…Garg et al . [ 8 ] reported a prevalence of 0.09% among 47,450 whole blood donors. On the contrary, Giblett[ 9 ] had reported 0.32% incidence of irregular RBC antibodies in blood donors.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of irregular red cell antibody in healthy blood donors attending a tertiary care hospital in North India

Makroo

Rajput

Agarwal

et al. 2018

Asian J Transfus Sci

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“…Así, en Singapur el uso de células Di a permitió determinar la presencia de aloinmunización por el sistema Diego en 19 de 1,383 muestras con resultados indeterminados en el panel de células comerciales 15 . Diversos estudios han determinado la presencia de aloanticuerpos anti-Di a en donantes de sangre, desde el 0.02% hasta el 13.0% 16 . En esta investigación se detectó una prevalencia del 6% de anti-Di a en donantes de sangre, mientras que en Texas en el área de Corpus Christi se reportó una prevalencia del 1.3% de aloanticuerpo anti-Di a en individuos con transfusiones previas 17 , en Brasil se identificaron 112 (3.6%) pacientes con anti-Di a , en Singapur se determinó una frecuencia del 1.37% 2,15 y en el estudio realizado en Guatemala se encontró una prevalencia del 3.5% de anti-Di a en pacientes multitransfundidos 10 .…”

Section: Resultsunclassified

Frecuencia del antígeno y aloanticuerpos del sistema Diego en donantes de sangre

Góngora

Chiriboga-Ponce

2018

GMM

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“…However other studies had higher prevalence 0.09-0.13 % [3,4]. These differences in prevalence may be due to variation in the study population and techniques used for detection.…”

mentioning

confidence: 83%

Significance of Adopting a Sensitive Technique for Donor Antibody Screening

Chenna

Shastry

Murugesan

2015

Indian J Hematol Blood Transfus

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Prevalence of irregular red blood cell antibodies among healthy blood donors in Delhi population

Cited by 28 publications

References 7 publications

Prevalence of irregular red cell antibody in healthy blood donors attending a tertiary care hospital in North India

Prevalence of irregular red cell antibody in healthy blood donors attending a tertiary care hospital in North India

Frecuencia del antígeno y aloanticuerpos del sistema Diego en donantes de sangre

Significance of Adopting a Sensitive Technique for Donor Antibody Screening

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