Prevalence of insulin resistance and its association with metabolic syndrome criteria among Bolivian children and adolescents with obesity

Caceres, M Eyshller; Teran, Carlos G; Rodriguez, Susana; Medina, Marcos

doi:10.1186/1471-2431-8-31

Cited by 87 publications

(78 citation statements)

References 31 publications

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“…Assim como nos adultos, a obesidade tem se convertido também em um problema de saúde nas crianças da América Latina, devido ao alto risco de persistência de obesidade na idade adulta e associar-se com o desenvolvimento de hipertensão arterial (22,50,51). 1) Circunferência da cintura aumentada, cuja definição é específica para cada população e para cada país; 2) Triglicerídios iguais ou maiores que 150 mg/dL, ou tratamento farmacológico para triglicerídios séricos elevados; 3) Redução de HDL-colesterol a menos de 40 mg/dL em homens e menos de 50 mg/dL em mulheres.…”

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Latin American consensus on hypertension in patients with diabetes type 2 and metabolic syndrome

López‐Jaramillo

Sánchez

Díaz³

et al. 2013

Journal of Hypertension

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Latin American consensus on hypertension in patients with diabetes type 2 and metabolic syndrome

López‐Jaramillo

Sánchez

Díaz³

et al. 2013

Journal of Hypertension

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“…Finally, a recent study conducted among Bolivian children and adolescents with obesity revealed an IR prevalence of 39?4 % by using a threshold of HOMA-IR . 3?5 (3) . IR in children and adolescents has been associated with CVD and metabolic disorders such as hypertension, dyslipidaemia, hepatic steatosis and endothelial dysfunction (6,7) .…”

mentioning

confidence: 99%

“…The prevalence of insulin resistance (IR) in children and adolescents is increasing around the world (1)(2)(3)(4)(5) . Although there is no universally accepted definition of IR, all studies evaluating the prevalence of IR indicate that more than one out of three obese children or adolescents display IR.…”

mentioning

confidence: 99%

Daily sugar-sweetened beverage consumption and insulin resistance in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study

Kondaki

Grammatikaki

Jiménez-Pavón

et al. 2012

Public Health Nutr.

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Objective: The present study aimed to evaluate the relationship between the consumption of selected food groups and insulin resistance, with an emphasis on sugar-sweetened beverages (SSB). Design: The present research is a large multicentre European study in adolescents, the HELENA-CSS (Healthy Lifestyle in Europe by Nutrition in Adolescence CrossSectional Study). Setting: Homeostasis model assessment-insulin resistance index (HOMA-IR) was calculated. Several anthropometric and lifestyle characteristics were recorded. Dietary assessment was conducted by using a short FFQ. Subjects: The participants were a subset of the original sample (n 546) with complete data on glucose, insulin and FFQ. All participants were recruited at schools. Results: Median (25th, 75th percentile) HOMA-IR was 0?62 (0?44, 0?87). Mean HOMA-IR was significantly higher among adolescents consuming brown bread #1 time/week than among those consuming 2-6 times/week (P 5 0?011). Mean values of HOMA-IR were also higher in adolescents consuming SSB .5 times/ week compared with those consuming less frequently, although a statistically significant difference was detected between those consuming SSB 5-6 times/ week and 2-4 times/week (P 5 0?049). Multiple linear regression analysis showed that only the frequency of SSB consumption was significantly associated with HOMA-IR after controlling for potential confounders. In particular, it was found that HOMA-IR levels were higher among adolescents consuming SSB 5-6 times/week and $1 time/d compared with those consuming #1 time/week by 0?281 and 0?191 units, respectively (P 5 0?009 and 0?046, respectively). Conclusions: The present study revealed that daily consumption of SSB was related with increased HOMA-IR in adolescents. Keywords Sugar-sweetened beveragesHigh frequence Consumption Homeostasis model assessment-insulin resistanceThe prevalence of insulin resistance (IR) in children and adolescents is increasing around the world (1)(2)(3)(4)(5) . Although there is no universally accepted definition of IR, all studies evaluating the prevalence of IR indicate that more than one out of three obese children or adolescents display IR. For instance, in Greece, the prevalence of IR was found to be 9?2 % (2?9 % in normal-weight, 10?5 % in overweight and 31?0 % in obese children), using the threshold of homeostasis model assessment-insulin resistance index (HOMA-IR) .

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“…The few studies of AN carried out in children or young participants, however, have not considered the knuckles as a site for investigation. 13 , 16 , 18 , 44 They have neither studied the diagnostic performance of AN to predict IR by HOMA-IR index.…”

Section: Discussionmentioning

confidence: 99%

Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance

González-Saldivar

Rodríguez-Gutiérrez

Treviño-Alvarez

et al. 2018

Dermato-Endocrinology

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Any clinical/biochemical marker revealing obesity or diabetes before their appearance is valuable. Insulin resistance (IR) is present in both disorders many years before occurrence. Accordingly, we determined whether acanthosis nigricans (AN) in the knuckles is associated to higher insulin and homeostasis model assessment for estimated insulin resistance (HOMA-IR) index values, and assessed the influence of body-mass index (BMI) and the diagnostic performance of AN in the knuckles to detect IR. In this cross-sectional controlled study, we included men or women, 18 to 23 years old, with or without AN in the knuckles. In 149 cases with AN in the knuckles and 145 controls, fasting insulin was higher in cases (13.45 µU/mL ± 7.8 vs. 8.59 µU/mL ± 3.63, P < .001, respectively). Mean HOMA-IR index was also higher (2.86 ± 1.68 vs. 1.78 ± 0.77, P < .001). A significant increase in fasting insulin and HOMA-IR values between and within BMI groups from normal through obese category was identified in controls and cases. By multivariate regression analysis, cases with normal BMI were significantly associated to a HOMA-IR ≥2.5 (OR = 3.09, CI95% = 1.75–5.48, P = .001). A model of AN in the knuckles, normal BMI, and increased waist circumference allowed identifying 2 out of 3 cases with HOMA-IR index ≥2.5. AN in the knuckles could be addressed with two aims: as an easy, accessible, and costless diagnostic tool suggesting hyperinsulinemia secondary to IR, and, an early marker of IR even in the absence of overweight or obesity.

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Prevalence of insulin resistance and its association with metabolic syndrome criteria among Bolivian children and adolescents with obesity

Abstract: Background: Obesity is a one of the most common nutritional disorder worldwide, clearly associated with the metabolic syndrome, condition with implications for the development of many chronic diseases.

Cited by 87 publications

References 31 publications

Latin American consensus on hypertension in patients with diabetes type 2 and metabolic syndrome

Latin American consensus on hypertension in patients with diabetes type 2 and metabolic syndrome

Daily sugar-sweetened beverage consumption and insulin resistance in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study

Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance

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