Prevalence of infection by different genotypes of human papillomavirus in women with cervical pathology

Mazarico, Edurne; González-Bosquet, Eduardo

doi:10.1016/j.ygyno.2011.12.450

Cited by 26 publications

(22 citation statements)

References 25 publications

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“…However, finding HPV-66 as the most frequent type in Buenos Aires was an unexpected result. Moreover, the HPV-66 frequencies that were found in this study were among the highest reported worldwide [Bruni et al, 2010; de Sanjose et al, 2010], and also among the recently published prevalence studies in which this type was identified [Castellsague et al, 2012; da Silva et al, 2012; Mazarico and Gonzalez-Bosquet, 2012]. These findings are due to the application of the CUT primers that appeared to have a differential specificity with respect to the MY11/09 primers (100/104 Vs 38/104, respectively) in detecting HPV-66 (Table I).…”

Section: Discussionsupporting

confidence: 55%

Prevalence of human papillomavirus infection in Argentinean women attending two different hospitals prior to the implementation of the National Vaccination Program

Chouhy

D'Andrea²,

Iglesias

et al. 2013

Journal of Medical Virology

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Cervarix vaccine was included in the National Immunization Program of Argentina in 2011 but data about the local distribution of human papillomavirus (HPV) infection in women exposed to the virus are scarce. This cross-sectional study determined the prevalence and type distribution of HPV infection in unvaccinated women attending routine gynaecological screening in two public hospitals located in Buenos Aires and Santa Fe, Argentina. Socio-demographic, sexual behaviour and co-factors information was obtained from all participants (Buenos Aires, n=429; Santa Fe, n=433). Cervicovaginal swabs were tested with an MY11/09 primer-based assay and with the CUT primer system targeting mucosal/cutaneous HPVs. Participants from Buenos Aires showed significantly higher rates of HPV infection (52.4% vs. 40.6%), of multiple infections (24.2% vs. 16.4%), and of low-risk (20.3% vs. 13.9%) and high-risk types (44.1% vs. 33.3%) than those from Santa Fe. HPV-66 (Buenos Aires: 17%) and HPV-16 (Santa Fe: 8.5%) were the most prevalent types. Novel HPV-66 putative subtype and variants were identified. Vaccine types 16 and 18 were frequent (Buenos Aires: 13.5%; Santa Fe F: 10.2%) but few participants had co-infections with both (Buenos Aires: 1.4%; Santa Fe: 0.2%). A common risk factor for HPV infection was having a new sexual partner in the last year (Buenos Aires: OR 2.53, p<0.001; Santa Fe: OR 1.85, p=0.04). This study provides valuable baseline data for future assessment of the impact of massive vaccination in Argentina and it underlines the use of additional HPV testing strategies, such as the CUT system, for surveillance and vaccinology.

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Section: Discussionsupporting

confidence: 55%

Prevalence of human papillomavirus infection in Argentinean women attending two different hospitals prior to the implementation of the National Vaccination Program

Chouhy

D'Andrea²,

Iglesias

et al. 2013

Journal of Medical Virology

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“…According to our data, 96.6% of CIN-I had HPV infection, HPV 16 being the most frequent genotype. This agreed with earlier investigations although with slightly lower percentages (22, 23). Also, although HPV 18 was the world’s second most frequent HPV genotype (24), it represented only 11.2% of our cases, a lower frequency than that of HPV 51 (19.8%), HPV 53 (19%), and HPV 31 (13.8%), in line with other works (25, 26).…”

Section: Discussionsupporting

confidence: 94%

Do clinical data and human papilloma virus genotype influence spontaneous regression in grade I cervical intraepithelial neoplasia?

Cortés-Alaguero¹,

González-Mirasol²,

Morales‐Roselló³

et al. 2017

J Turkish German Gynecol AssocJ Turkish German Gynecol Assoc

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Objective:To determine whether medical history, clinical examination and human papilloma virus (HPV) genotype influence spontaneous regression in cervical intraepithelial neoplasia grade I (CIN-I).Material and Methods:We retrospectively evaluated 232 women who were histologically diagnosed as have CIN-I by means of Kaplan-Meier curves, the pattern of spontaneous regression according to the medical history, clinical examination, and HPV genotype.Results:Spontaneous regression occurred in most patients and was influenced by the presence of multiple HPV genotypes but not by the HPV genotype itself. In addition, regression frequency was diminished when more than 50% of the cervix surface was affected or when an abnormal cytology was present at the beginning of follow-up.Conclusion:The frequency of regression in CIN-I is high, making long-term follow-up and conservative management advisable. Data from clinical examination and HPV genotyping might help to anticipate which lesions will regress.

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“…In this study, HPV was detected in 81.0% of the examined population. This high rate of HPV prevalence correlate with some previously published studies [26][27][28][29]. [33] and Milutin-Gasperov [34].…”

Section: Discussionsupporting

confidence: 90%

Tissue Detection and Typisation of Human Papillomavirus in Women with Squamous Intraepithelial Lesions and Squamous Invasive Carcinoma of the Cervix

Dabeski¹,

Danilovski²,

Antovska³

et al. 2015

Macedonian Medical Review

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Introduction. The most common risk factor for intraepithelial lesions and cervical carcinoma is infection with human papillomavirus (HPV), especially with high-risk HPV genotypes. Only persistent, high-risk HPV infections represent a major risk factor for intraepithelial lesions and cervical cancer. The aims of the study were: detection and typisation of HPV genotypes, which are the most common causes of intraepithelial lesions and cervical cancer, determination of the correlation between HPV infection and histopathological diagnosis, and the correlation between the grade of lesion of the cervix and oncogenic potential of the virus as well as determination of the most affected age group of patients. Methods. This cross-sectional study included 100 sexually active patients with an abnormal Pap test at the age from 20 to 69 years (39±10.77), and was conducted at the University Clinic of Gynecology and Obstetrics in Skopje and University Clinic of Radiotherapy and Oncology in Skopje in the period from January 2014 to August 2014. In all patients colposcopic cervical biopsy was made with endocervical curettage for histopathological analysis and cervical biopsy for detection and HPV typisation. HPV detection and typisation were done using polymerase chain reaction (PCR) and reverse hybridization. Results. HPV DNA was detected in 81.0% (81/100) of the examined women. The relationship between the prevalence of high-risk and low-risk HPV DNA genotypes was 72.0%:9.0%. The frequency of high-risk HPV DNA genotypes ranged from: 54.5% (12/22) in productive HPV infection-mild dysplasia, 86.4% (19/22) with moderate dysplasia, 91.2% (21/23) in severe dysplasia

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Prevalence of infection by different genotypes of human papillomavirus in women with cervical pathology

Cited by 26 publications

References 25 publications

Prevalence of human papillomavirus infection in Argentinean women attending two different hospitals prior to the implementation of the National Vaccination Program

Prevalence of human papillomavirus infection in Argentinean women attending two different hospitals prior to the implementation of the National Vaccination Program

Do clinical data and human papilloma virus genotype influence spontaneous regression in grade I cervical intraepithelial neoplasia?

Tissue Detection and Typisation of Human Papillomavirus in Women with Squamous Intraepithelial Lesions and Squamous Invasive Carcinoma of the Cervix

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