Prevalence of increased arterial stiffness and peripheral arterial disease in patients with systemic sclerosis

Τζιόμαλος, Κωνσταντίνος; Gkougkourelas, Ioannis; Sarantopoulos, Alexandros; Bekiari, Eleni; Raptis, Nikolaos; Makri, Eleftheria; Tselios, Konstantinos; Pantoura, Marianna; Hatzitolios, Apostolos; Boura, Panagiota

doi:10.1016/j.atherosclerosis.2016.07.805

Cited by 1 publication

(6 citation statements)

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“…June and Scalzi reported also a higher percentage of SLE patients with PAD than controls (33% World Journal of Cardiovascular Diseases versus 20%) with a statistically significant difference [11]. However, Tziomalos et al, didn't find a statistic difference in the prevalence of PAD between SLE patients and controls (10% versus 5.4% p-value = NS) [8]. Nevertheless, there is difference in definition of ABI in these studies.…”

Section: Discussionmentioning

confidence: 77%

“…Any other clinical data in the time of the diagnostic and inclusion, or cardiovascular risk factors, lupus specific related factors and corticosteroid therapy were correlated with ABI abnormalities (Tables 3-6). Whether atherosclerosis in coronary artery, has been widely studied in the literature, peripheral arterial disease has been infrequently described [8] [17]. We reported, in our best knowledge, we reported the first study in sub-Saharan Africa, who compared ABI in patients with SLE between controls.…”

Section: Resultsmentioning

confidence: 91%

“…reported in 2016, only four similar studies prior to their publication about the prevalence and the determinants of abnormal ABI in patients with SLE. Three of these previous studies did not include a control population [8].…”

Section: Discussionmentioning

confidence: 99%

“…ABI has facilitated the detection of subclinical PAD [14]. However, there are very limited data about abnormal ABI in patients with SLE [8] [17]. The aim of the present study was to compare ABI between SLE patients and controls.…”

Section: Introductionmentioning

confidence: 94%

“…Traditional cardiovascular factors (including Diabetes mellitus, hypertension, tobacco, atherogenic dyslipidemia), SLE therapies such as corticosteroid and disease-related factors (subclinical inflammation, oxidative stress, antiphospholipid antibodies) appear to contribute to the increasing of incidence of cardiovascular events in SLE [5] [8] [9] [10].…”

Section: Introductionmentioning

confidence: 99%

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Ankle-Brachial Index in Systemic Lupus Erythematosus: A Senegalese Case-Control Study

Kane¹,

Sow²,

Aw³

et al. 2019

WJCD

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Systemic lupus erythematosus (SLE) is associated with accelerated atherosclerosis and increasing cardiovascular risk which is recognized as a major cause of morbidity and death. Whether subclinical atherosclerosis has been evaluated by several methods, there are very limited data about Ankle-Brachial Index (ABI) in patients with systemic lupus erythematosus. The aim of the present study was to compare this index, between SLE patients and controls. We conducted a case-control study in the Department of Internal Medicine of our institution during the period from August 1, 2017 to December 31, 2018. We included 100 subjects, including 50 SLE patients and 50 control cases. This included 44 women and 6 men in patients with an identical distribution in controls. The mean age was 33.5 ± 11.3 years for cases and 33.3 ± 11.3 years (p-value: 0.93) for controls subjects. There was higher frequency of cardiovascular risk factors such as dyslipidemia (p-value at 0.009), low level of serum HDL-cholesterol (p-value < 0.001), hypertriglyceridemia (p-value at 0.000) and hyperuricemia (p-value at 0.000) in patients with SLE. Overweight/obesity was higher in controls subjects (p-value at 0.028). There was no statistically significant difference in the frequency of diabetes-mellitus, smoking and high blood pressure. The abnormally ABI was recorded in 19 patients with SLE (38%) and 8 controls (16%) with a p-value: 0.01 and odds ratio: 3.22. Eight patients (16%) and four controls (8%) had low ABI without significant difference (p-value: 0.11 but odds-ratio at 2.98). Eleven patients with SLE (22%) and five controls (10%) had high ABI (p-value: 0.05 and odds-ratio: 3.24). In patients with SLE only disease activity (cSLEDAI) at the inclusion of the study was correlated to abnormal ABI. Conclusion: This

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Section: Discussionmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%