Prevalence of Imipenem-Resistant Acinetobacter baumannii isolates in Iran: A Meta-Analysis

Derakhshan, M H; Heidary, Leila; Shams, Saeed

doi:10.52547/iem.7.1.77

Cited by 5 publications

(5 citation statements)

References 9 publications

(9 reference statements)

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“…In recent years, the emergence of drug-resistant bacteria has been a public health concern in developing regions 28 – 30 . Excessive prescription of available antibiotics led to a mutation in bacteria and was conducive to the expansion of multidrug resistance in the bacteria, especially V. cholerae strains.…”

Section: Discussionmentioning

confidence: 99%

Effects of chitosan nanoparticles loaded with mesenchymal stem cell conditioned media on gene expression in Vibrio cholerae and Caco-2 cells

Saberpour

Najar-peeraye

Shams

et al. 2022

Sci Rep

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Vibrio (V.) cholerae forms a pellicle for self-defense in the pathological conditions in the intestine, which protects it against antibiotics and adverse conditions. Targeting biofilm genes and Toll-like receptors (TLRs) is one of the new strategies to combat multidrug-resistant bacteria. The objective of this study was to evaluate the effect of mesenchymal stem cell conditioned media (MSC CM; 1000 µg), chitosan nanoparticles incorporated with mesenchymal stem cell conditioned media (MSC CM-CS NPs; 1000 µg + 0.05%), and chitosan nanoparticles (CS NPs; 0.05%) on the expression of bap1 and rbmC biofilm genes in V. cholerae and TLR2 and TLR4 genes in Caco-2 cells. The bacteria were inoculated in the presence or absence of MSC CM, MSC CM-CS NPs, and CS NPs for 24 h at 37 °C to evaluate the expression of biofilm genes. The Caco-2 cells were also exposed to V. cholerae for 1 h and then MSC CM, MSC CM-CS NPs, and CS NPs for 18 h at 37 °C. After these times, RNA was extracted from Caco-2 cells and bacteria exposed to the compounds, and the expression of target genes was evaluated using real-time PCR. Caco-2 cell viability was also assessed by MTT assay. After adding MSC CM, MSC CM-CS NPs, and CS NPs to V. cholerae medium, the percentage reduction in gene expression of bap1 was 96, 91, and 39%, and rbmC was 93, 92, and 32%, respectively. After adding MSC CM, MSC CM-CS NPs, and CS NPs to the Caco-2 cell medium, the percentage reduction in the gene expression of TLR4 was 89, 90, and 82%, and TLR2 was 41, 43, and 32%, respectively. MTT showed that Caco-2 cell viability was high and the compounds had little toxicity on these cells. Finally, it suggests that MSC CM-CS NPs designed may be a therapeutic agent to combat inflammation and biofilm formation in multidrug-resistant V. cholerae. However, further studies in vivo are also recommended.

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Section: Discussionmentioning

confidence: 99%

Effects of chitosan nanoparticles loaded with mesenchymal stem cell conditioned media on gene expression in Vibrio cholerae and Caco-2 cells

Saberpour

Najar-peeraye

Shams

et al. 2022

Sci Rep

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“…These bacteria can lead to urinary tract infections, infectious poisoning, inflammation of the stomach or intestines, jaundice and infections of the abdominal cavity, pneumonia or wound infections ( 12 , 13 ). In the last decade, over-prescription or incorrect prescription of antibiotics has led to the emergence of antibiotic resistance to a significant extent ( 14 , 15 ). Microbial antibiotic resistance is a growing public health problem that complicates and increases the cost of medical treatment to $ 30 billion per year ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Comparing the Bacterial Flora of Insectary and Filed Strains of Supella longipalpa (Blattaria: Ectobiidae) and their Antibiotic Resistant Pattern in Qom Province, Central Iran

Veysi,

Kababian,

Khalifeh Gholi

et al. 2024

JAD

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Background: Cockroaches play a role in the mechanical transmission of microbial pathogens. This study was designed to determine the isolated bacteria and their susceptibility to conventional antibiotics from brown-banded cockroach, Supella longipalpa, in Qom province, central Iran. Methods: In this cross-sectional study, brown-banded cockroaches were bred in an insectary and caught from hospitals of Qom. The samples were taken from the surface and alimentary canal and then cultured on microbial culture media; next, grown specimens were identified using differential culture media. Finally, after performing diagnostic tests and identifying the bacteria species, their susceptibility to various antibiotics was evaluated. Results: A total of 120 adult cockroaches from the insectary and hospitals were included in the study. Ten bacterial genera were found; nine were Gram-negative and one was Gram-positive. The genus Klebsiella, Enterobacter, Staphylococcus, Citrobacter and Hafnia were isolated only from the hospital strain. On the other hand, Pseudomonas and Escherichia from both groups and other species such as Salmonella, Proteus and Shigella were isolated only from laboratory strains. The highest antibiotic resistance among Gram-positive cocci and Gram-negative bacilli were 100.0% and 98.1% for ampicillin and Ceftazidime, respectively. Conclusion: The results of this study showed that various pathogenic bacteria harbored by brown-banded cockroaches. Moreover, it was found that most of these bacteria belong to the Enterobacteriaceae family, which can be pathogenic and thus threaten human health.

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“…Moreover, the frequency of resistance to antibiotics such as penicillins, cephalosporins, and carbapenems is increasing in beta-lactamase-producing species causing nosocomial UTIs, and causative microorganisms of CAUTI are more resistant than those of UTI due to the CAUTI being multi-bacterial [8,[13][14][15][16]. These highlight the important role of microbiological data in clinical judgement as well as the need for more regional and local studies on the characteristics of causative pathogens [6,17].…”

Section: Introductionmentioning

confidence: 99%

“…The results of previous studies and retrospective reviews conducted worldwide, including in Iran at both national and regional levels, indicated different epidemiological and antibiotic susceptibility patterns and related risk factors in patients with CAUTI [10,13,[18][19][20][21]. In some studies conducted in Iran, Escherichia coli has been reported as the most isolated pathogen from CAUTIs, but the frequency and the resistance pattern differ [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

“…In some studies conducted in Iran, Escherichia coli has been reported as the most isolated pathogen from CAUTIs, but the frequency and the resistance pattern differ [21][22][23]. Also, the antimicrobial resistance pattern in Gram-negative bacilli causing urinary tract infections in Iran is changing, and reports indicate an increase in carbapenems resistance [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Clinical and microbiological patterns in critically ill patients with catheter-associated UTI: A report from Iran

Salehi

Robati

SeyedAlinaghi

et al. 2023

J Infect Dev Ctries

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Introduction: Catheter-associated urinary tract infections (CAUTIs) are among the most common nosocomial infections with different clinical and microbiological characteristics. We studied these characteristics in critically ill patients. Methodology: This research was a cross-sectional study conducted on intensive care unit (ICU) patients with CAUTI. Patients’ demographic and clinical information and laboratory data, including causative microorganisms and antibiotic susceptibility tests, were recorded and analyzed. Finally, the differences between the patients who survived and died were compared. Results: After reviewing 353 ICU cases, 80 patients with CAUTI were finally included in the study. The mean age was 55.9 ± 19.1 years, 43.7% were male and 56.3% were female. The mean length of infection development since hospitalisation and hospital stay were 14.7 (3–90) and 27.8 (5–98) days, respectively. The most common symptom was fever (80%). The microbiological identification showed that the most isolated microorganisms were Multidrug-resistant (MDR) Enterobacteriaceae (75%), Pseudomonas aeruginosa (8.8%), Gram-positive uropathogens (8.8%) and Acinetobacter baumannii (5%). Fifteen patients (18.8%) died among whom infections with A. baumannii (75%) and P. aeruginosa (57.1%) were associated with more death (p = 0.005). Conclusions: Although A. baumannii and P. aeruginosa can be the most important pathogens for death, MDR Enterobacteriaceae are still a serious concern as causes of CAUTIs.

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Prevalence of Imipenem-Resistant Acinetobacter baumannii isolates in Iran: A Meta-Analysis

Cited by 5 publications

References 9 publications

Effects of chitosan nanoparticles loaded with mesenchymal stem cell conditioned media on gene expression in Vibrio cholerae and Caco-2 cells

Effects of chitosan nanoparticles loaded with mesenchymal stem cell conditioned media on gene expression in Vibrio cholerae and Caco-2 cells

Comparing the Bacterial Flora of Insectary and Filed Strains of Supella longipalpa (Blattaria: Ectobiidae) and their Antibiotic Resistant Pattern in Qom Province, Central Iran

Clinical and microbiological patterns in critically ill patients with catheter-associated UTI: A report from Iran

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