Prevalence of IgG and IgM antibodies specific to Toxoplasma gondii in cats

Svobodová, Vlasta; Knotek, Z.; Svoboda, Martin

doi:10.1016/s0304-4017(98)00201-5

Cited by 39 publications

(30 citation statements)

References 3 publications

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“…Antibodies to T. gondii were found in 31% of 86 dogs (Havlik and Hubner, 1958), 57% dogs (Vokoun, 1982), 50% of 1 002 dogs (Svoboda and Svobodova, 1987), 36.7% of 240 clinically normal and 54.2% of diseased dogs (Svoboda et al, 1987a). In cats, 91% of 86 (Havlik and Hubner, 1958) and 40.3% of 620 had antibodies to T. gondii in SFR (Svoboda et al, 1988a) and 61.3% of 357 in IFAT (Svobodova et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

The prevalence of Toxoplasma gondiiIgM and IgG antibodies in dogs and cats from the Czech Republic

Sedlák¹,

Bártová²

2006

Vet. Med.

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Sera of 413 dogs and 286 cats from the CzechRepublicwere tested for antibodies to Toxoplasma gondii by the indirect fluorescent antibody test. The IgM antibodies to T. gondii were found in 10 (2.4%) dogs and 8 (2.8%) cats; IgG antibodies were found in 107 (25.9%) dogs and 126 (44.1%) cats. Of the dogs, the most exposed group were pet dogs, followed by police dogs; no antibodies were found in laboratory dogs. No statistically significant differences in prevalence were observed between clinically healthy (n = 115) and diseased pet dogs (n = 80); compare 0.87% and 1.25% for IgM, and 33.9% and 33.75% for IgG, respectively. Although T. gondii is a common parasite in domestic cats and dogs, the clinical importance is low.

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Section: Discussionmentioning

confidence: 99%

The prevalence of Toxoplasma gondiiIgM and IgG antibodies in dogs and cats from the Czech Republic

Sedlák¹,

Bártová²

2006

Vet. Med.

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“…In the United States, the incidence of acute toxoplasma infection during pregnancy has been estimated to be approximately 0.2 to 1.0%, although in about 90% of cases the disease goes unrecognized (25). In some countries, the seroprevalence of IgM antibodies has been reported to be as high as 2.4% (23). Identifying the time of primary infection is crucial for the clinical management of pregnant women because of an inverse correlation between the severity of toxoplasmosis for the fetus and the gestational age (14,25).…”

mentioning

confidence: 99%

“…Infected babies may not develop any disease, or they may experience serious damage to the brain and eyes. The detection of recently acquired infection in pregnant women is therefore critical for clinical management of the mother and her fetus (19,20,23,25). PCR amplification of T. gondii DNA in blood cells, body fluids, and tissues has been used successfully for the diagnosis of congenital toxoplasmosis; however, its reliability with amniotic fluid samples before 18 weeks of gestational age is unknown (5,21).…”

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confidence: 99%

Detection of Immunoglobulin M Antibodies Specific for Toxoplasma gondii with Increased Selectivity for Recently Acquired Infections

2004

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Toxoplasma gondii infections can cause serious complications in pregnant women, leading to miscarriage, stillbirth, and birth defects. Definitive diagnosis of T. gondii acute infection is therefore critical for the clinical management of a mother and her fetus. Positive immunoglobulin M (IgM) results are not sufficient as evidence of recent infection, as these antibodies are often present for many months. Further, IgG avidity and differential agglutination tests, two tests used by reference laboratories to distinguish between recent and past infections, are not always in agreement, and both methods yield a significant number of indeterminate results. We report the development of a new toxoplasma IgM immunoassay that is performed by using a bead-based immunoassay on an automated analyzer (BioPlex 2200). Initial validation included 204 samples from pregnant women and 198 samples from asymptomatic healthy adults. An overall specificity of 99% was observed. Further, 100% sensitivity for acute infections was observed for 10 well-characterized seroconversion panels. We then examined 50 samples from pregnant women, all of which were IgM positive by ELISA, which had been fully evaluated in a reference laboratory. Of the 50 samples, 34 (68%) tested positive in the BioPlex 2200 toxoplasma IgM assay, of which 32 of 34 (94%) exhibited an acute or equivocal pattern by differential agglutination. Of the 16 negative samples, 15 (94%) showed high-IgG-avidity antibodies. Collectively, these results suggest that this new toxoplasma assay shows a preferential response to IgM antibodies produced by recent infections, reducing the number of positive results for pregnant women that will require extensive additional clinical evaluation.

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“…On the other hand, performance of the MAT for detection of IgM antibodies against T. gondii in naturally infected animals is less clear and there have been few systematic evaluations of the assay for this purpose. IgM antibodies can be detected 1 to 2 weeks before the development of a measurable IgG antibody titer (Svobodova et al, 1998). The primary problem with testing for anti-Toxoplasma IgM is lack of specificity (Lappin, 2010).…”

Section: Igg Versus Igmmentioning

confidence: 99%

Toxoplasma in Animals, Food, and Humans: An Old Parasite of New Concern

Cenci‐Goga

Rossitto

Sechi

et al. 2011

Foodborne Pathogens and Disease

141

106

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All hosts, including humans, can be infected by any one of the three forms of the parasite Toxoplasma gondii that correspond to three morphological stages: tachyzoite, bradyzoite, and sporozoite form. Felids are definitive hosts for T. gondii, which is an intracellular pathogen that infects a wide range of warm-blooded intermediate hosts. Toxoplasmosis is a disease where the interest of the diverse medical and veterinary specialties converge. Awareness needs to be increased that toxoplasmosis can induce clinical disease not only in immunocompromised patients or through congenital infections, but also in healthy patients. This is a review article that aims at illustrating why toxoplasmosis should be regarded a veterinary public health issue and how veterinary practitioners can contribute in controlling the infection.

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Prevalence of IgG and IgM antibodies specific to Toxoplasma gondii in cats

Cited by 39 publications

References 3 publications

The prevalence of Toxoplasma gondiiIgM and IgG antibodies in dogs and cats from the Czech Republic

The prevalence of Toxoplasma gondiiIgM and IgG antibodies in dogs and cats from the Czech Republic

Detection of Immunoglobulin M Antibodies Specific for Toxoplasma gondii with Increased Selectivity for Recently Acquired Infections

Toxoplasma in Animals, Food, and Humans: An Old Parasite of New Concern

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