Prevalence of IgG-4-associated cholangiopathy based on serum IgG-4 levels in patients with primary sclerosing cholangitis and its relationship with inflammatory bowel disease

Taghavi, Seyed Alireza; Majd, Shaghayegh Kaedi; Sianati, Mahnoosh; Sepehrimanesh, Masood

doi:10.5152/tjg.2016.16344

Cited by 11 publications

(8 citation statements)

References 18 publications

(36 reference statements)

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“…With severe cholestasis and advanced liver disease in the present patient, primary sclerosing cholangitis (PSC) was considered. IgG4-associated PSC has been reported in adults 25 and in children 26 and can be associated with AIP 1. In the present patient, anatomopathological analyses of the liver biopsy specimen did not No confirmed case of AIP 1 has been reported in the pediatric population to date.…”

Section: Commentarymentioning

confidence: 99%

Autoimmune Pancreatitis and Ulcerative Rectocolitis in an Adolescent

Cousin¹,

Cousin

Aziz

et al. 2018

Pediatrics

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Autoimmune pancreatitis (AIP) is rare in teenagers and difficult to diagnose. There are no clear and established diagnostic criteria in the pediatric population to distinguish subtype 1 and subtype 2. Here, we report the case of a 16-year-old white French teenager admitted to the pediatric emergency service with more than 1 year's history of pain originating from the epigastric and the right hypochondriac regions, with bloody diarrhea. After exclusion of pancreatic cancer and other common causes of acute pancreatitis, the diagnosis of AIP was suspected. Biological analyses revealed acute pancreatitis with severe cholestasis and an elevated level of serum immunoglobulin G4. Magnetic resonance cholangiography revealed a voluminous pancreas presenting a typical "sausage-like" aspect. Anatomopathological analyses of the liver biopsy specimen revealed a biliary obstruction due to pancreatic involvement without the typical aspect of chronic destructive cholangitis. Corticotherapy and immunosuppressive treatment proved effective after 1 week of treatment. Without a pancreatic biopsy specimen, the distinction between AIP type 1 and 2 could not be made clearly in this case. The succession of clinical observations could allow clinicians to recognize, treat, and manage AIP in children.

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Section: Commentarymentioning

confidence: 99%

Autoimmune Pancreatitis and Ulcerative Rectocolitis in an Adolescent

Cousin¹,

Cousin

Aziz

et al. 2018

Pediatrics

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“…Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most effective techniques in the diagnosis and treatment of biliary ducts and pancreas disorders. 1 However, this technique is accompanied by certain complications and among them, pancreatitis is the most common and serious ones. Post-ERCP pancreatitis (PEP) identified as clinical signs of acute pancreatitis after ERCP with elevated levels of pancreatic enzymes.…”

Section: Introductionmentioning

confidence: 99%

Naproxen, isosorbide dinitrate and co-administration cannot prevent post-endoscopic retrograde cholangiopancreatography pancreatitis: Randomized controlled trial

Mansour-Ghanaei¹,

Joukar

Khalesi³

et al. 2020

Ann Hepatobiliary Pancreat Surg

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Backgrounds/Aims: Acute pancreatitis is the most widespread complication of endoscopic retrograde cholangiopancreatography. Here, we investigated the efficacy of rectal suppository naproxen, sublingual isosorbide dinitrate and their co-administration in the prevention of post-ERCP pancreatitis. Methods: This double-blind randomized clinical trial carried out from June 2015 to February 2016 at the Gastrointestinal and Liver Diseases Research Center in Rasht, Iran. A total of 585 patients were selected from candidates for diagnostic or therapeutic ERCP by using the simple sampling method. Patients divided into three groups. Group A received 500 mg naproxen, group B took 5 mg isosorbide dinitrate, and group C was co-administrated both agents before ERCP. The primary outcome measure was the development of pancreatitis onset of pain in the upper abdomen and increase of serum amylase activity more than 3 times over the upper normal limit (60-100 IU/L) within first the 24 h post-ERCP. Results: Totally, 80 patients developed PEP included 29 (4.9%), 24 (4.1%), and 27 (4.6%) patients in groups A, B, and C, respectively (p=0.845). Longer ERCP time (p=0.041), using diazepam (p=0.033), a higher number of pancreatic ducts cannulation (p＜0.001), pancreatic duct injection (p=0.013), and using pancreatic stent (p=0.004) were the predisposing factors for PEP. Conclusions: Our findings indicated that prophylactic naproxen suppository or isosorbide dinitrate sublingually or co-administration had no significant difference in the prevention and severity of PEP, however, enhancing the endoscopist's skills can be effective. Departments and educational hospitals should develop their assessment and quality assurance measures for the training of fellows' not only technical training but also an understanding of the diagnostic and therapeutic roles of the procedure.

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“…The use of biomarkers for the diagnosis of biliopancreatic diseases, including PC, has been previously described. [22–24] Bartsch et al [25] showed that the circulating levels of LCN2 and TIMP1 transcripts could be useful for the early diagnosis of PC. Here, we report that the abundance of MSX2 and PDX1 transcripts are good serum biomarkers for discriminating between non-PC and PC patients.…”

Section: Discussionmentioning

confidence: 99%