Prevalence of Helicobacter pylori infection with healthy subjects in Japan

Abstract

Background and Aim: Only few large-scale epidemiological studies have examined the prevalence of Helicobacter pylori (H. pylori) infection in Japan. The aim of the present study was to estimate the prevalence and incidence of H. pylori infection in Japan in terms of gender, age and region. Methods: Serum anti-H. pylori antibody testing was included in workers' annual health checks conducted by T-company's health insurance association in 2008. The testing was continued for the next 5 years in 35-year-old subjects. Results: The total number of subjects was 21 144 (18 398 males and 2746 females). Stratified for age, there were 5016 subjects (male : female = 4219:797) in their 30s, 8748 (7770:978) in their 40s, 5589 (4807:782) in their 50s, and 1769 (1584:185) in their 60s. The H. pylori seropositive rate (male : female) was 27.5% (27.5:27.7) overall, 18.0% (18.3:16.1) in subjects in their 30s, 22.9% (22.7:24.7) in those in their 40s, 37.4% (37.2:38.2) in those in their 50s, and 46.1% (45.7:49.2) in those in their 60s. The prevalence of H. pylori seropositivity increased as age increased; however, no significant differences were seen between genders or among regions (χ 2 test).

Natural Course of <b><i>Helicobacter pylori</i></b> Infection in Japanese Hemodialysis Patients

“…At a time when the H. pylori infection rate is decreasing in Japan, we showed here an infection rate in 500 patients receiving hemodialysis of 15.0%, which is significantly lower than the current rate in healthy Japanese individuals (37.4% in the sixth decade and 46.1% in the seventh decade in 2014) [16] or in hemodialysis patients in a worldwide meta-analysis (43.9%) [27] reported in 2011. In addition, we demonstrated that H. pylori infection in 19.6% patients receiving hemodialysis was considered to be naturally eradicated, although they had no specific treatment history.…”

“…A recent large-scale Japanese epidemiological study showed that the infection rate has declined to 30-50%, especially in younger patients [16]. The prevalence of H. pylori infection in patients receiving dialysis has been investigated, and in most studies, the infection rate in patients with chronic kidney disease receiving continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis is shown to be equal to or lower than that in subjects with normal renal function in various population groups [17,18,19,20].…”

Analysis of allelic variants of rdxA associated with metronidazole resistance in Helicobacter pylori: detection of common genotypes in rdxA by multiplex allele-specific polymerase chain reaction

“…Approximately 50% of the world population are infected with H. pylori; however, the rate of infection is variable among countries: for example, the infection rate is 62% in China, 27.5% in Japan, 65.6% in Vietnam, and 45.9% in Thailand (Shi et al, 2008;Nguyen et al, 2010;Hirayama et al, 2014;Uchida et al, 2015). Metronidazole (Mtz) is a standard triple therapy recommended by the 1994 National Institute of Health Consensus for H. pylori eradication (NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease, 1994).…”

Cost-Effectiveness Analysis of Helicobacter Pylori Diagnostic Methods in the Patients with Atrophic Gastritis

“…While the prevalence of Helicobacter pylori (H. pylori) has been decreasing [1,2], it remains a critical public health issue. Recently, increasing prevalence of CAM-resistant H. pylori is an emerging problem of public health all over the world as CAM is included in most first-line empiric H. pylori eradication regimens [3,4].…”