Prevalence of <i>Helicobacter pylori</i> in Georgian Patients with Dyspepsia

Olivares, Asalia; Buadze, Merab; Kutubidze, Tina; Lobjanidze, M.; Labauri, Levani; Chikviladze, D; Zhvania, M; Kharzeishvili, Omar; Lomidze, N; Perez-Perez, Guillermo I.

doi:10.1111/j.1523-5378.2006.00367.x

Cited by 11 publications

(13 citation statements)

References 18 publications

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“…In the current study, the prevalence of cagA among patients infected with H. pylori was 70%, which was in accordance with reports from Iraq (71%) and Turkey (78%) [25,29]. It was also consistent with reports from Europe and North America [30,34]. However, the prevalence obtained from the present study was lower than that reported from Southeast Asia (93% positive for cagA) by a similar metaanalysis study [35].…”

Section: Discussionsupporting

confidence: 92%

Prevalence of cagA and vacA among Helicobacter pylori-infected patients in Iran: a systematic review and meta-analysis

Sayehmiri

Kiani

Sayehmiri

et al. 2015

J Infect Dev Ctries

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The varieties of infections caused by Helicobacter pylori may be due to differences in bacterial genotypes and virulence factors as well as environmental and host-related factors. This study aimed to investigate the prevalence of cagA and vacA genes among H. pylori-infected patients in Iran and analyze their relevance to the disease status between two clinical groups via a meta-analysis method. Different databases including PubMed, ISI, Scopus, SID, Magiran, Science Direct, and Medlib were investigated, and 23 relevant articles from the period between 2001 and 2012 were finally analyzed. The relevant data obtained from these papers were analyzed by a randomeffects model. Data were analyzed using R software and STATA. The prevalence of cagA and vacA genes among H. pylori-infected patients was 70% (95% CI, 64-75) and 41% (95% CI, 24.3-57.7), respectively. The prevalence of duodenal ulcers, peptic ulcers, and gastritis among cagA+ individuals was 53% (95% CI, 20-86), 65% (95% CI, 34-97), and 71% (95% CI, 59-84), respectively. Odds ratio (OR) between cagA-positive compared with cagA-negative patients showed a 1.89 (95% CI, 1.38-2.57) risk of ulcers. In conclusion, the frequency of cagA gene among H. pylori strains is elevated in Iran and it seems to be more frequently associated with gastritis. Therefore, any information about cagA and vacA prevalence among different H. pylori-infected clinical groups in the country can help public health authorities to plan preventive policies to reduce the prevalence of diseases associated with H. pylori infection.

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Section: Discussionsupporting

confidence: 92%

Prevalence of cagA and vacA among Helicobacter pylori-infected patients in Iran: a systematic review and meta-analysis

Sayehmiri

Kiani

Sayehmiri

et al. 2015

J Infect Dev Ctries

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“…This suggests that there should be certain factors other than H. pylori infection to induce peptic ulcer disease in children. Moreover, H. pylori-related peptic ulcer diseases in children with abdominal pain were less frequent (1.1-1.3%) than in dyspeptic adults (17.7-72.7%) [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection can change the intensity of gastric Lewis antigen expressions differently between adults and children

Yang

Sheu

et al. 2007

J Biomed Sci

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This study tested whether there were different expressions of gastric Lewis antigens between children and adults with Helicobacter pylori infection, and whether the difference was related to the infection outcome. About 68 dyspeptic children and 110 dyspeptic adults were enrolled to check H. pylori infection, its colonization density, and the related histology. Gastric Lewis antigens b (Le(b)), x (Le(x)), and sialyl-Lewis x (sialyl-Le(x)) were immunohistochemically stained and scored for the intensity. The H. pylori-infected adults, but not the children, had a lower Le(b) intensity over the antrum (p=0.019) but higher Le(b) intensity over the corpus (p=0.001) than the non-infected ones. Over the antrum, both the H. pylori-infected children and adults had a lower Le(x) and higher sialyl-Le(x) intensity than those non-infected ones (p<0.05). The H. pylori-infected adults had a higher bacterial density (p=0.004) and Le(b) intensity (p=0.016) over the corpus than the H. pylori-infected children. For the H. pylori-infected adults, but not children, the corpus had a higher Le(b) (p=0.038) and lower Le(x) (p=0.005) intensity than the antrum. Furthermore, the H. pylori-infected adults expressed a higher Le(b) and had a higher bacterial density than those with weak Le(b) (antrum, p<0.001; corpus, p=0.001). In conclusion, H. pylori infection is associated with the intensity change of Lewis antigen expressions in the stomach. The changes of gastric Lewis antigen expressions are different between adults and children with H. pylori infection, which may exert different H. pylori colonization over the corpus between adults and children.

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“…The annual incidence rate of H. pylori infection is ≈4%-15% in developing countries, compared with ≈0.5% in industrialized countries (4). Studies in the Republic of Georgia (ROG), a developing country with an economy in transition, suggested that >70% of adults are infected with H. pylori (5,6) and that the prevalence rate of gastric cancer is 18 cases per 100,000 population, ≈6-to 9-fold higher than in the United States (National Center for Disease Control, Tbilisi, ROG, unpub. data, 2003).…”

Section: Helicobacter Pylori Infection In Patients Undergoing Upper Ementioning

confidence: 99%

Helicobacter pyloriInfection in Patients Undergoing Upper Endoscopy, Republic of Georgia

Tarkhashvili¹,

Beriashvili²,

Chakvetadze³

et al. 2009

Emerg. Infect. Dis.

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Prevalence of Helicobacter pylori in Georgian Patients with Dyspepsia

Abstract: We confirmed that among individuals in Georgia, the prevalence of H. pylori is high and cagA-positive strains were equally present among H. pylori-positive patients with PUD and NUD and asymptomatic persons.

Cited by 11 publications

References 18 publications

Prevalence of cagA and vacA among Helicobacter pylori-infected patients in Iran: a systematic review and meta-analysis

Prevalence of cagA and vacA among Helicobacter pylori-infected patients in Iran: a systematic review and meta-analysis

Helicobacter pylori infection can change the intensity of gastric Lewis antigen expressions differently between adults and children

Helicobacter pyloriInfection in Patients Undergoing Upper Endoscopy, Republic of Georgia

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