Prevalence of <i>Helicobacter pylori</i> among Alaskans: Factors associated with infection and comparison of urea breath test and anti‐<i>Helicobacter pylori</i> IgG antibodies

Miernyk, Karen; Bulkow, Lisa; Gold, Benjamin D.; Bruce, Michael G.; Hurlburt, Debby; Griffin, Patricia M.; Swerdlow, David L.; Cook, Kim; Hennessy, Thomas W.; Parkinson, Alan J.

doi:10.1111/hel.12482

Cited by 35 publications

(54 citation statements)

References 54 publications

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“…Several hypotheses have been raised to explain these inequalities, including difference in social habits and higher rates of H . pylori infection; however, studies to confirm these hypotheses are rare …”

Section: Discussionmentioning

confidence: 99%

Planning mass eradication of Helicobacter pylori infection for indigenous Taiwanese peoples to reduce gastric cancer

Bair

Chuang

Lei

et al. 2019

J of Gastro and Hepatol

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Background and Aim The aim of this study is to identify gastric cancer burden in Indigenous Taiwanese peoples and conduct a project to evaluate how to reduce the disparities most effectively in Indigenous communities. Methods First, we quantified the health disparities in gastric cancer in Indigenous peoples using data from the cancer registries during the period of 2006–2014. Second, we identified parameters that might be associated with Helicobacter pylori infection or help identify a good eradication strategy. Results Gastric cancer incidence (24.4 vs 12.3 per 100 000 person‐years) and mortality rates (15.8 vs 6.8 per 100 000 person‐years) were higher in Indigenous than in non‐Indigenous, with 2.19‐fold (95% confidence interval [CI]: 2.06–2.33) and 2.47‐fold (2.28–2.67) increased risk, respectively. In Indigenous communities, H. pylori infection was more prevalent in Indigenous than in non‐Indigenous (59.4% vs 31.5%, P < 0.01). Regression analyses consistently showed that either the mountain or plain Indigenous had 1.89‐fold (95% CI: 1.34–2.66) and 1.73‐fold (95% CI: 1.24–2.41) increased risk for H. pylori infection, respectively, as compared with non‐Indigenous, adjusting for other baseline characteristics. The high infection rates were similarly seen in young, middle‐aged, and older adults. Program eradication rates using clarithromycin‐based triple therapy were suboptimal (73.7%, 95% CI: 70.0–77.4%); the habits of smoking (1.70‐fold, 95% CI: 1.01–2.39) and betel nut chewing (1.54‐fold, 95% CI: 0.93–2.16) were associated with the higher risk of treatment failure. Conclusion Gastric cancer burden is higher in Indigenous Taiwanese peoples than in their non‐Indigenous counterparts. Eliminating the prevalent risk factor of H. pylori infection is a top priority to reduce this health disparity.

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Section: Discussionmentioning

confidence: 99%

Planning mass eradication of Helicobacter pylori infection for indigenous Taiwanese peoples to reduce gastric cancer

Bair

Chuang

Lei

et al. 2019

J of Gastro and Hepatol

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“…The prevalence of the infection was 68%‐69% (depending on the test used). The factors associated with H. pylori positivity were: Alaska Native racial status, age ≥20 years, rural region of residence, living in a crowded home, and drinking water that was not piped or delivered …”

Section: Global Prevalence Of Helicobacter Pylori Infectionmentioning

confidence: 99%

“…30 Another H. pylori prevalence study was reported from Alaska. 31 Altogether 710 participants from six communities and one urban city to represent four geographical regions in Alaska were recruited from 1996 to 1997. The prevalence of the infection was 68%-69% (depending on the test used).…”

Section: Asiamentioning

confidence: 99%

“…The factors associated with H. pylori positivity were: Alaska Native racial status, age ≥20 years, rural region of residence, living in a crowded home, and drinking water that was not piped or delivered. 31 A couple of studies addressed H. pylori epidemiology in Hispanic populations. In Texas, an overall 20% seropositivity in men was reported based on biorepository samples collected to study prostate cancer.…”

Section: Asiamentioning

confidence: 99%

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Epidemiology of Helicobacter pylori infection

et al. 2018

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This review provides the most recent data concerning the epidemiology of Helicobacter pylori infection. Overall, the trend of declining prevalence of H. pylori infection is continuing, with major evidence available from studies in Europe. However, in some parts of the world, for example, in some countries in the Middle East, the prevalence has remained relatively stable. A number of systematic reviews and meta-analyses have been published during the past year indicating the lowest prevalence rates of the infection in Oceania (24.4%), the highest in Africa (79.1%), and the global annual recurrence rate of H. pylori (4.3%). The recurrence rates were found to be directly related to the human development index and prevalence of infection. Several studies have addressed the correlation between H. pylori infection and sociodemographic conditions, source of drinking water and dietary factors. A hypothesis on the role of insects and yeasts in transmitting H. pylori has been suggested and addressed. Helicobacter sp. have been found in flow flies in Brazil. So far there is no evidence available that H. pylori may survive and persist on the outer body of the fly.

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“…Investigators at the Centers for Disease Control and Prevention present an analysis of data collected more than 20 years ago among Alaskan Natives regarding Helicobacter pylori infection and gastric cancer . This is the newest of a series of investigations regarding H. pylori and its consequences in the Native Alaskan population.…”

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confidence: 99%

Editorial: Helicobacter pylori and gastric cancer in Alaskan Natives: Time to stop studying H. pylori and to eradicate it

2018

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Prevalence of Helicobacter pylori among Alaskans: Factors associated with infection and comparison of urea breath test and anti‐Helicobacter pylori IgG antibodies

Abstract: Background: Helicobacter pylori is one of the most common human infections in the

Cited by 35 publications

References 54 publications

Planning mass eradication of Helicobacter pylori infection for indigenous Taiwanese peoples to reduce gastric cancer

Planning mass eradication of Helicobacter pylori infection for indigenous Taiwanese peoples to reduce gastric cancer

Epidemiology of Helicobacter pylori infection

Editorial: Helicobacter pylori and gastric cancer in Alaskan Natives: Time to stop studying H. pylori and to eradicate it

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