Prevalence of Brucella endocarditis: A systematic review and meta‐analysis

Abstract

Background Endocarditis caused by Brucella infection is one of this infection's complications, including a high mortality rate. However, studies on the prevalence of this complication have been limited to some case reports. This study investigated the prevalence of Brucella endocarditis globally using a systematic review and meta‐analysis. Methods PubMed, Scopus, and Web of Science databases were searched using appropriate keywords until September 2022. All studies reporting the prevalence of endocarditis in patients with brucellosis were included in this current study. To investigate the pooled prevalence of Brucella endocarditis, random model was used in comprehensive meta‐analysis software. Results A total of 25 studies met the inclusion criteria and were included in the systematic review and meta‐analysis. The prevalence of Brucella endocarditis was 1.3%, and the death rate was 26.5%. The results did not show a significant difference in the prevalence of this complication in different regions. Conclusion According to this study's results, the prevalence of Brucella endocarditis is low, but it includes a large percentage of the deaths of affected patients. To complete our understanding of this complication and its management, more research should be done to investigate the effect of other factors, such as age and gender.

Incidence and Outcomes of Brucella Endocarditis in a High-Prevalence Area: A Single-Center Study

“…The heart valves invaded in this study were mainly aortic and mitral valves, including a case of a mitral valve prosthesis. The findings were in line with the valve involvement described in the literature [15]. The majority of patients presented with solitary vegetation, with more than half of the valve vegetation measuring > 10 mm in diameter.…”

Brucella infection presenting as infective endocarditis complicated by embolic stroke

“…Cardiac involvement in brucellosis is rare but may be fatal. Infective endocarditis, the most common cardiac complication, is only found in 0.3–2% of the cases [7] , [8] , [9] . Nevertheless, it accounts for approximately 80% of the mortality in brucellosis [2] .…”

“…Complications from brucellosis occur in approximately 30% of infected individuals and may involve any system, including osteoarticular, genitourinary, cardiac, and others [5] , [6] . One of the rare complications of Brucella infection is endocarditis, affecting approximately 1.3% of individuals [7] . This case report describes a rare occurrence of Brucella endocarditis presenting as an embolic stroke.…”