Prevalence of hypothyroidism among Arabs with rheumatoid arthritis.

Al-Awadhi, Adel; Olusi, S.O.; Al-Zaid, N. S.; Prabha, K; Al-Ali, Najla; Al-Jarallah, Khaled; George, Sabu

doi:10.1093/rheumatology/38.5.472

Cited by 6 publications

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“…Twenty-nine studies met the inclusion criteria, involving 35,708 RA patients and 149,421 non-RA controls. Among them, 15 studies ( 5 , 11 , 13 , 22 , 24 , 25 , 27 , 31 , 33 , 34 ) provided ( 37 – 40 , 45 ) prevalence values for hyperthyroidism, 12 provided ( 5 , 11 , 22 , 24 , 31 , 33 , 34 , 36 , 37 , 42 , 44 , 45 ) prevalence values for subclinical hyperthyroidism, 26 provided ( 5 , 11 , 13 , 14 , 22 – 31 , 33 – 41 , 43 , 45 , 46 ) prevalence values for hypothyroidism, and 17 provided ( 5 , 11 , 14 , 22 , 24 , 31 – 34 , 36 – 39 , 42 – 45 ) prevalence values for subclinical hypothyroidism. The NOS checklist was used to evaluate the quality of studies, and 7 studies (24.13%) assessed as high quality, and 18 studies (62.07%) identified as medium quality.…”

Section: Resultsmentioning

confidence: 99%

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Association between rheumatoid arthritis and thyroid dysfunction: A meta-analysis and systematic review

et al. 2022

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ObjectiveRheumatoid arthritis (RA) is an autoimmune disorder. Multiple studies have investigated the risk of thyroid dysfunction in patients with RA but have reached conflicting conclusions. This systematic review aimed to determine whether patients with RA are at higher risk of thyroid dysfunction.MethodsWe comprehensively reviewed online literature databases, including PubMed, Scopus, Embase, and the Cochrane Library, from their respective inception dates to March 25, 2022. Studies that provided data on at least one case of thyroid dysfunction in RA patients and their controls were included. Based on these data, we calculated pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) for thyroid dysfunction in RA and non-RA patients.ResultsTwenty-nine studies met the inclusion criteria, involving a total of 35,708 patients with RA. The meta-analysis showed that, compared with non-RA patients, RA patients had an increased risk of developing thyroid dysfunction, particularly hypothyroidism (OR 2.25, 95% CI 1.78–2.84). Subgroup analysis suggested that study type and sample source of control group were the source of heterogeneity.ConclusionsPatients with RA are at increased risk of developing thyroid dysfunction, especially hypothyroidism. Routine biochemical examination of thyroid function in RA patients should be strengthened. Larger prospective studies are needed to explore the causal relationship between RA and thyroid dysfunction, and to investigate the impact of thyroid dysfunction on RA disease activity, drug efficacy, and medication safety.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022331142.

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Section: Resultsmentioning

confidence: 99%

“…( 33 ), neither group included any cases of hypothyroidism. We thus conducted a combined analysis of the remaining 25 studies ( 5 , 11 , 13 , 14 , 22 – 28 , 31 , 34 – 41 , 43 , 45 , 46 ) ( Figure 2C ). Due to the high I 2 value (I 2 = 75.7%), a random-effects model was applied.…”

Section: Resultsmentioning

confidence: 99%

Association between rheumatoid arthritis and thyroid dysfunction: A meta-analysis and systematic review

et al. 2022

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“…There have been no detailed reports in the literature on the frequency of abnormal thyroid function tests and the presence of thyroid autoantibodies in healthy Kuwaitis or in those with autoimmune diseases other than our previous short report limited to the prevalence of hypothyroidism in patients with RA [16] , but there are detailed reports on other Arabs [17,18] . Therefore, the present study was designed to investigate the frequency of abnormal thyroid function tests in healthy Kuwaiti Arabs and in those with RA, SLE, and pSS.…”

Section: Introductionmentioning

confidence: 87%

Frequency of Abnormal Thyroid Function Tests in Kuwaiti Arabs with Autoimmune Diseases

Al-Awadhi

Olusi²,

Hasan³

et al. 2008

Med Princ Pract

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Objectives: The purpose of this study was to examine the frequencies of abnormal thyroid function tests and serum thyroid autoantibodies in healthy Kuwaitis and those with autoimmune diseases. Subjects and Methods: Serum concentrations of sensitive thyrotropin, and free thyroxine were measured in 577 apparently healthy controls, 177 patients with rheumatoid arthritis (RA), 60 with systemic lupus erythematosus (SLE) and 25 with primary Sjogren’s syndrome (pSS) using the immunochemiluminescent assay method on IMMULITE 1000. Serum microsomal and thyroglobulin autoantibodies were also measured by passive hemagglutination assay. For analysis of the thyroid function tests, the subjects were classified into five categories: normal, subclinical hypothyroidism, overt hypothyroidism, euthyroid sick syndrome and biochemical hyperthyroidism. Results: Subclinical hypothyroidism was seen in 1.7% of healthy controls, 10.2% of RA, 13.3% of SLE, and 16% of pSS patients. Among RA patients, the frequency of subclinical hypothyroidism in females (11.4%) was significantly higher than among males (5.4%; p < 0.01). In SLE and pSS patients, all those with subclinical hypothyroidism were females. Overt hypothyroidism was seen in 1.4% of controls, 10.2% of RA, 8.3% of SLE, and 4% of pSS patients. Biochemical hyperthyroidism was seen in 0.2% of controls, 4.5% of RA, 5% of SLE and none of pSS patients. The euthyroid sick syndrome was seen in 0.4% of controls, 13.6% of RA, 16.7% of SLE and in none of pSS patients. Thyroid autoantibodies were present in 3.1% of controls, 12.4% of RA, 18.3% of SLE, and 12% of pSS patients. Conclusion: Our data show that abnormal thyroid function tests and thyroid autoantibodies occur frequently in Ku-waitis with autoimmune diseases. Therefore, ordering these tests in these diseases is recommended.

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“…By opening their statement as such, IOMS is noting that ascertaining death falls within the realm of juridical and ethical discretion (ijtihad). 39 Since the moment of death is not determined by any univocal normative sources in Islamic law and ethics, from the perspective of Islamic bioethics determining death only requires the criteria to meet a dominant probability threshold.…”

Section: Certainty Of Medical Testimonymentioning

confidence: 99%

“…While it has some gaps the IOMS acknowledged that 'concerning the applicability of other rulings (regarding unstable life), the jurists preferred to defer discussing them for a future occasion.' 41 Yet upon reconvening in 1996 the IOMS did not bring jurists back to the table and felt no need to change their verdicts. However, clinical and ethical controversies, and the medical science around brain death, have changed considerably since the 1980s.…”

Section: Medical Rights Of the Brain-stem Dead Individualmentioning

confidence: 99%

Brain Death in Islamic Ethico‐legal Deliberation: Challenges for Applied Islamic Bioethics

2011

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Since the 1980s, Islamic scholars and medical experts have used the tools of Islamic law to formulate ethico-legal opinions on brain death. These assessments have varied in their determinations and remain controversial. Some juridical councils such as the Organization of Islamic Conferences' Islamic Fiqh Academy (OIC-IFA) equate brain death with cardiopulmonary death, while others such as the Islamic Organization of Medical Sciences (IOMS) analogize brain death to an intermediate state between life and death. Still other councils have repudiated the notion entirely. Similarly, the ethico-legal assessments are not uniform in their acceptance of brain-stem or whole-brain criteria for death, and consequently their conceptualizations of, brain death. Within the medical literature, and in the statements of Muslim medical professional societies, brain death has been viewed as sanctioned by Islamic law with experts citing the aforementioned rulings. Furthermore, health policies around organ transplantation and end-of-life care within the Muslim world have been crafted with consideration of these representative religious determinations made by transnational, legally-inclusive, and multidisciplinary councils. The determinations of these councils also have bearing upon Muslim clinicians and patients who encounter the challenges of brain death at the bedside. For those searching for 'Islamically-sanctioned' responses that can inform their practice, both the OIC-IFA and IOMS verdicts have palpable gaps in their assessments and remain clinically ambiguous. In this paper we analyze these verdicts from the perspective of applied Islamic bioethics and raise several questions that, if answered by future juridical councils, will better meet the needs of clinicians and bioethicists.

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Prevalence of hypothyroidism among Arabs with rheumatoid arthritis.

Cited by 6 publications

References 0 publications

Association between rheumatoid arthritis and thyroid dysfunction: A meta-analysis and systematic review

Association between rheumatoid arthritis and thyroid dysfunction: A meta-analysis and systematic review

Frequency of Abnormal Thyroid Function Tests in Kuwaiti Arabs with Autoimmune Diseases

Brain Death in Islamic Ethico‐legal Deliberation: Challenges for Applied Islamic Bioethics

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