2017
DOI: 10.1007/s12020-017-1289-2
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Prevalence of hypophysitis in a cohort of patients with metastatic melanoma and prostate cancer treated with ipilimumab

Abstract: Clinicians should be aware about the risk of hypophysitis during treatment with immune check-point inhibitors and the necessity of investigating pituitary function during therapy. Pituitary magnetic resonance imaging does not seem pivotal for a definite diagnosis if not performed at the onset of disease.

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Cited by 40 publications
(30 citation statements)
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“…However, their use is associated with broad immunological adverse events, such as enterocolitis, hypophysitis, and pancreatitis [1, 2, 3, 4]. Notably, enterocolitis has been reported in up to approximately 8$ of patients who have received ipilimumab [5].…”
Section: Discussionmentioning
confidence: 99%
“…However, their use is associated with broad immunological adverse events, such as enterocolitis, hypophysitis, and pancreatitis [1, 2, 3, 4]. Notably, enterocolitis has been reported in up to approximately 8$ of patients who have received ipilimumab [5].…”
Section: Discussionmentioning
confidence: 99%
“…Hepatitis and hypophysitis are also adverse events related to immunotherapy (14)(15)(16). Hypothetically, activation of the immune system could result in increased 18 F-FDG activity in the spleen.…”
Section: Discussionmentioning
confidence: 99%
“…Hence, normal imaging of the pituitary does not ex-clude its diagnosis [27]. Corticotropic, thyrotropic and gonadotropic functions are mostly affected, but long term failure of the corticotropic axis is paramount [10,25,112]. High-dose glucocorticoids are proposed for those with mass effect symptoms, such as severe headache or visual-field disturbance [27,113,114].…”
Section: Hypophysitismentioning
confidence: 99%