Prevalence of hyperuricemia in Bangkok population

Abstract

To investigate the prevalence of hyperuricemia in general Thai population and to evaluate its association with metabolic syndrome. A total of 1,945 subjects who sought for routine annual health checkup in our hospital from 1 October 2009 to 31 March 2010 were enrolled into the study. Inclusion criteria were healthy individuals, aged ≥35 years old, and lived in Bangkok for over 10 years. Data of general health status, age, gender, history of alcoholic consumption, body weight, height, and waist circumference were obtained by an interview-structured questionnaire. Fasting blood sample was collected from each subject early in the morning for uric acid, total cholesterol, high density lipoprotein cholesterol, triglycerides, and glucose levels. The prevalence of hyperuricemia in our study population was 24.4%, being significantly more common in men than women (59% vs. 11%, p < 0.001). The condition was also associated with various features of high body mass index or waist circumference, alcohol consumption, dyslipidemia, and high fasting blood glucose. Metabolic syndrome was found in 35% and 23% of men and women with hyperuricemia; direct relationship between level of uric acid and prevalence of metabolic syndrome was observed. Hyperuricemia is common among Bangkok population in our study. This disorder is frequently associated with metabolic syndrome.

Metabolic syndrome, diabetes, and hyperuricemia

“…In patients with manifest atherosclerosis, both presence of more than three metabolic risk factors and the presence of a high waist circumference are associated with increased risk of future type 2 diabetes [15]. Some case series studies [16,17] reported that the prevalence of metabolic syndrome was high among patients with gout. Moreover, hyperuricemia has been associated with metabolic syndrome in studies [18][19][20] of both healthy individuals and patients.…”

“…It may also precipitate cardiovascular diseases for which the metabolic syndrome is a strong risk factor. The most different in the prevalence of hyperuricemia was found in male adults with metabolic syndrome compared with nonmetabolic syndrome [17] and higher prevalence of metabolic syndrome was also found in men with hyperuricemia [17]. Even in those with normouricemia, higher serum uric acid levels were associated with metabolic syndrome [21 & ].…”

Cross-sectional and longitudinal associations between serum uric acid and metabolic syndrome: Results from Fangchenggang Area Male Health and Examination Survey in China

“…Previous studies have demonstrated that the prevalence of MetS was high among patients with gout [11]. Other authors have claimed that, even healthy individuals, hyperuricemia was associated with MetS [12].…”

Evaluation of serum uric acid in acute ischaemic stroke

“…10 Another large study in Bangkok population showed that prevalence of hyperuricemia is 24.4%. 11 According to these studies prevalence of hyperuricemia is significantly higher in patients with acute stroke than normal population. These findings are consistent with our study as patients with hyperuricemia were more in stroke patients as compared to control group.…”