Prevalence of hypertension and associated risk factors in Chinese Jing compared with Mulao populations

Xie, Rui-Bin; Liao, Pei-Juan; Yin, Rong; Hu, Xi‐Jiang; Huang, Jiehong; Wei, Dai-Xun; Li, Hui; Huang, Feng; Yao, Limei; Pan, Shang‐Ling; Dezhai, Yang; Lin, Wei

doi:10.1177/0300060515587579

Cited by 5 publications

(5 citation statements)

References 46 publications

(83 reference statements)

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“…Many studies have indicated that obesity, hypertension, and high blood sugar are three physiological conditions that could be elevated by stress to increase the risk of cardiovascular diseases ( 42 – 45 ). Another result in our study indicated that systolic pressure, BMI, and blood sugar, which are cardiovascular risk-related factors, in the offspring born from stress-burdened mothers during pregnancy were significantly higher than the control group.…”

Section: Discussionmentioning

confidence: 99%

Earthquake Experience at Different Trimesters during Pregnancy Is Associated with Leukocyte Telomere Length and Long-term Health in Adulthood

Wang

et al. 2017

Front. Psychiatry

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Leukocyte telomere length (LTL) is a predictor of age-related diseases, cancer, and even early mortality. Prenatal stress experience has been suggested to associate with short LTL and an increased disease risk in adult life. The present study aimed to evaluate the 39-year effects of prenatal earthquake stress (PES) exposure on LTL and increased age-related disease risk in adulthood. Here, we compared the LTL in the subjects who were exposed to PES to healthy controls (CN) and evaluated whether stress exposure at different times during pregnancy is associated with a shorter LTL and long-term health conditions in adulthood. LTL was measured in 100 adults who experienced the 1976 7.8 Richter scale Tangshan earthquake of the Hebei province in utero and divided them into first, second, and third trimester groups according to the exposure timing during pregnancy. A total of 80 healthy volunteers from Shijiazhuang of the Hebei province were also assessed for their LTL. The telomere-to-single copy gene (T/S) ratio of the PES group (0.78 ± 0.06, p = 0.04) showed a significantly lower LTL than the CN group (0.97 ± 0.08). The results of the LTL analysis indicated that the subjects who experienced PES in the second (0.69 ± 0.09, p = 0.04) or third trimester (0.67 ± 0.76, p = 0.02) showed significantly shorter LTLs compared with those in the first trimester group (0.99 ± 0.12). A fully adjusted regression model indicated the same conclusions. In addition, we found that systolic pressure (SBP; 129.32 ± 14.86 mmHg, p = 0.041), body mass index (BMI; 22.54 ± 2.71, p = 0.046), and low-density lipoprotein (LDL; 3.09 ± 0.98 mmol/L, p = 0.048) in the subjects with PES were significantly higher than those measurements in the CN subjects (SBP; 122.06 ± 10.55 mmHg; BMI; 20.24 ± 2.13; LDL; 2.91 ± 0.76 mmol/L), and there was a significant negative correlation between an increased adult hypertension risk and a shorter LTL.

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Section: Discussionmentioning

confidence: 99%

Earthquake Experience at Different Trimesters during Pregnancy Is Associated with Leukocyte Telomere Length and Long-term Health in Adulthood

Wang

et al. 2017

Front. Psychiatry

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“…The inclusion criteria were the following: (1) In accordance with the diagnostic criteria for hypertension in the “Chinese Guidelines for the Prevention and Treatment of Hypertension (revised 2018)”: in a quiet state without using antihypertensive drugs, the blood pressure values were continuously monitored three times on different days, with mean systolic blood pressure ≥ 140 mmHg (1 mmHg = 0.133 kPa) and/or diastolic blood pressure ≥ 90 mmHg. Having a history of hypertension and treated with antihypertensive drugs, although the blood pressure did not reach the above level during the physical examination, it was also diagnosed as hypertension [ 11 – 13 , 16 – 21 ]. (2) All subjects are residents of the Zhuang ethnic group with three generations of ancestors in the central region of Guangxi Zhuang Autonomous Region, and their clinical data were complete.…”

Section: Methodsmentioning

confidence: 99%

“…It is also the main culprit causing disability or death among middle-aged and elderly people [ 7 – 10 ]. With the rapid development of China’s economy, changes in lifestyle, intensification of population aging, and advancement of urbanization, hypertension has become a major public health problem [ 11 – 13 ]. The China Hypertension Survey (CHS) found that the crude prevalence rate of hypertension among residents aged ≥ 18 years in China from 2012 to 2015 was 27.9%, with an estimated number of 245 million people affected.…”

Section: Introductionmentioning

confidence: 99%

“…The crude examination rate of prehypertension was 39.1%, and the estimated number of people with prehypertension was 435 million [ 14 ]. However, the prevalence of hypertension is not consistent across the country and among ethnic groups, generally higher in the north than in the south, and higher in cities than in rural areas [ 3 , 13 , 15 ]. Although the exact cause and pathogenesis of hypertension are not yet fully understood, it is widely believed that hypertension is a disease influenced by various factors such as lifestyle, diet, physical inactivity, genetic factors, and their interactions [ 16 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Relationship between the methylenetetrahydrofolate reductase (MTHFR) rs1801133 SNP and serum homocysteine levels of Zhuang hypertensive patients in the central region of Guangxi

Hu,

Su,

Cao

et al. 2023

Clin Hypertens

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Background The relationship between the methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphism (SNP) and serum homocysteine (Hcy) levels or H-type hypertension in different populations is inconsistent. This study aimed to explore the association between the MTHFR rs1801133 SNP and serum Hcy levels of Zhuang hypertensive patients in the central region of Guangxi. Methods A total of 606 Zhuang inpatients with essential hypertension were recruited in our hospital from August 2016 to December 2018. The patients were divided into H-type hypertension (Hcy > 10 µmol/L, n = 528) and non–H-type hypertension (Hcy ≤ 10 µmol/L, n = 78) groups. At the same time, an age- and sex-matched group of 379 subjects with normal physical examination in our hospital were selected as the control group. Blood biochemical measurements and genotyping of the MTHFR rs1801133 SNP were performed. Results The prevalence of H-type hypertension was 87.13%. The levels of serum Hcy in patients with hypertension were higher than those in control group (14.20 ± 5.78 μmol/L vs. 11.97 ± 5.39 μmol/L, P < 0.001), especially in patients with H-type hypertension (15.08 ± 5.65 μmol/L, P < 0.001). The frequencies of TT genotype (22.73%) and T allele (46.21%) in patients with H-type hypertension were significantly higher than those in control group (11.35% and 30.47%, respectively) and non–H-type hypertension group (10.26% and 28.85%, respectively; P < 0.001 for all). Multivariate linear regression analysis showed that serum Hcy levels were significantly correlated with creatinine, low-density lipoprotein cholesterol, endogenous creatinine clearance rate, and the MTHFR rs1801133 genotypes in control group, while serum Hcy levels were significantly correlated with creatinine, triglyceride, low-density lipoprotein cholesterol, endogenous creatinine clearance rate, glycosylated hemoglobin, and the MTHFR rs1801133 genotypes in H-type hypertension group (P < 0.05–0.001). Serum Hcy levels in the T allele carriers were higher than those in the T allele noncarriers in both H-type hypertension and control groups. Conclusions There was closely related between the MTHFR rs1801133 SNP and serum Hcy levels in Zhuang patients with H-type hypertension in the central region of Guangxi. The MTHFR SNP may be an important reason for the increase of serum Hcy levels in Zhuang patients with H-type hypertension in this region.

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“…In the instance of Xining, a high-altitude, low-temperature city in China, the health implications of cold spells could surpass those associated with heatwaves [ 11 ]. Additionally, the hypoxic conditions typical of high altitudes may contribute to secondary polycythemia, heightened blood viscosity, and increased peripheral vascular resistance, notably affecting diastolic blood pressure, thus amplifying disease risk, a situation potentially aggravated by cold spells [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Health impacts of a cold wave and its economic loss assessment in China’s high-altitude city, Xining

Ning,

He,

Liao

et al. 2024

Arch Public Health

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Objective Amidst climate change, extensive research has centered on the health impacts of heatwaves, yet the consequences of cold spells, particularly in cooler, higher-altitude regions, remain under-explored. Methods Analyzing climatic data and non-accidental mortality in Xining, China’s second-highest provincial capital, from 2016 to 2020, this study defines cold spells as daily mean temperatures below the 10th, 7.5th, or 5th percentiles for 2–4 consecutive days. A time-stratified case-crossover approach and distributional lag nonlinear modeling were used to assess the link between cold spells and mortality, calculating attributable fractions (AFs) and numbers (ANs) of deaths. The study also examined the impact of cold spells over different periods and analyzed the value of a statistical life (VSL) loss in 2018, a year with frequent cold spells. Stratified analyses by sex, age, and education level were conducted. Results A significant association was found between cold spells and non-accidental mortality, with a relative risk of 1.548 (95% CI: 1.300, 1.845). The AF was 33.48%, with an AN of 9,196 deaths during the study’s cold period. A declining trend in mortality risk was observed from 2019–2020. The 2018 VSL was approximately 2.875 billion CNY, about 1.75% of Xining’s GDP. Higher risks were noted among males, individuals aged ≥ 65, and those with lower education levels. Conclusion The findings underscore the vulnerability and economic losses of high-altitude cities to cold spells. Implementing interventions such as improved heating, educational programs, and community support is vital for mitigating these adverse health effects.

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Prevalence of hypertension and associated risk factors in Chinese Jing compared with Mulao populations

Abstract: Prevalence of hypertension and associated risk factors were different between the two ethnic minorities, which might result from the combined effects of differences in their geographic, dietary, lifestyle, and genetic backgrounds.

Cited by 5 publications

References 46 publications

Earthquake Experience at Different Trimesters during Pregnancy Is Associated with Leukocyte Telomere Length and Long-term Health in Adulthood

Earthquake Experience at Different Trimesters during Pregnancy Is Associated with Leukocyte Telomere Length and Long-term Health in Adulthood

Relationship between the methylenetetrahydrofolate reductase (MTHFR) rs1801133 SNP and serum homocysteine levels of Zhuang hypertensive patients in the central region of Guangxi

Health impacts of a cold wave and its economic loss assessment in China’s high-altitude city, Xining

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