Prevalence of Hyperkalemia among Hemodialysis Patients in Egypt

Khedr, Essam; Abdelwhab, Saeed; El-Sharkay, Magdy; Ali, Medhat; Said, K.

doi:10.3109/08860220903216097

Cited by 22 publications

(9 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because residual urine volume is an independent risk factor for the development of hyperkalemia, its protection will help prevent this complication. 7 Moreover, the distribution of blood potassium in and out of cells is signi cantly related to the acid-base balance of the extracellular uid. In patients on hemodialysis, metabolic acidosis often occurs owing to disordered excretion of organic acids.…”

Section: Discussionmentioning

confidence: 99%

Incidence of hyperkalemia in patients on maintenance hemodialysis and risk-factor analysis

Xie,

Kong,

Liang

et al. 2023

Preprint

View full text Add to dashboard Cite

Objective: For patients on maintenance hemodialysis, hyperkalemia has now been lowered from 5.5 mmol/L to 5.0 mmol/L. We undertook this study in order to clarify the incidence of hyperkalemia under this new criterion, to determine the associated risk factors, and to provide guidance for the prevention of hyperkalemia. Methods: Data from all hemodialysis centers of Foshan City were included in a crosssectional survey, the overall incidence of hyperkalemia was determined and the risk factors were analyzed. Results: Our study comprised 2582 patients from 34 dialysis centers. 107 patients (4.14%) with serum potassium levels at or below 3.5 mmol/L, 1473(57.05%) with serum potassium levels between 3.5 and 5.0 mmol/L, 494 (19.13%) with serum potassium levels between 5.0 and 5.5 mmol/L, and 508 (19.67%) with serum potassium levels above 5.5 mmol/L. The Incidence of hyperkalemia was significantly greater under the new criterion than the old criterion (38.81% vs 19.67%, P <0.001). We divided the patients into non-hyperkalemia and hyperkalemia groups by the new criterion. Patients in the hyperkalemia group were younger, higher body-mass indices (BMIs), higher systolic and diastolic blood pressures, higher serum creatinine, higher serum blood urea nitrogen (BUN), lower pre-dialysis carbon dioxide combining power (CO2CP), and less residual urine volume(RUV), higher proportion of using angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs). Through multiple logistic regression analysis, we found that systolic blood pressure, RUV, ACEI/ARB usage, pre-dialysis CO2CP, and pre-dialysis BUN were independent risk factors for hyperkalemia. Conclusion: In the Foshan area, the incidence of hyperkalemia in patients on maintenance hemodialysis is very high. Under the new criterion, the diagnosis rate of hyperkalemia would be significantly increased. Moreover, high systolic blood pressure,decreased RUV, decreased pre-dialysis CO2CP, increased pre-dialysis BUN, and the use of ACEIs/ARBs were found to be independent risk factors for hyperkalemia.

show abstract

Section: Discussionmentioning

confidence: 99%

Incidence of hyperkalemia in patients on maintenance hemodialysis and risk-factor analysis

Xie,

Kong,

Liang

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…At the same time, potassium exchange resins have been shown to be effective in lowering plasma potassium concentrations in anuric patients with hyperkalemia (30), suggesting that potassium bioaccumulation from inadequate fecal potassium excretion may contribute to hyperkalemia in this population, despite the apparent lack of association with dietary potassium intakes (12 –14). Supporting this concept, constipation has been found to be associated with hyperkalemia in at least one observational study of patients on HD (31), and laxative use in people with advanced CKD was associated with significantly lower risk of hyperkalemia (odds ratio, 0.79; 95% confidence interval, 0.76 to 0.84) (32). In addition, in a small pilot study of patients with kidney failure ( n =13), treatment with Bisacodyl (Dulco-lax) was associated with a significant decrease in plasma potassium concentrations (5.9±0.2–5.5±0.2 mEq/L; P <0.001) (33).…”

Section: What Is In a Name?mentioning

confidence: 96%

Can Novel Potassium Binders Liberate People with Chronic Kidney Disease from the Low-Potassium Diet?

St-Jules¹,

Clegg²,

Palmer³

et al. 2022

CJASN

View full text Add to dashboard Cite

The advent of new potassium binders provides an important breakthrough in the chronic management of hyperkalemia for people with CKD. In addition to the direct benefits of managing hyperkalemia, many researchers and clinicians view these new medications as a possible means to safely transition patients away from the low-potassium diet to a more healthful eating pattern. In this review, we examine the mechanisms of potassium binders in the context of hyperkalemia risk related to dietary potassium intake in people with CKD. We note that whereas these medications target hyperkalemia caused by potassium bioaccumulation, the primary evidence for restricting dietary potassium is risk of postprandial hyperkalemia. The majority of ingested potassium is absorbed alongside endogenously secreted potassium in the small intestines, but the action of these novel medications is predominantly constrained to the large intestine. As a result and despite their effectiveness in lowering basal potassium levels, it remains unclear whether potassium binders would provide protection against hyperkalemia caused by excessive dietary potassium intake in people with CKD. Until this knowledge gap is bridged, clinicians should consider postprandial hyperkalemia risk when removing restrictions on dietary potassium intake in people with CKD on potassium binders.

show abstract

“…Reported rates depend on the investigated population, setting and applied cut‐off levels (Table 1). 2,15–21 The scarcity of data is a limitation for the awareness about hyperkalemia in the GCC region and its appropriate management. Well‐designed studies to explore the prevalence of hyperkalemia in the GCC and potential relations with complications in patients with HF or CKD are warranted.…”

Section: Definition Prevalence and Risk Factors Of Hyperkalemiamentioning

confidence: 99%

Prevalence and management of hyperkalemia in chronic kidney disease and heart failure patients in the Gulf Cooperation Council (GCC)

AlSahow

AbdulShafy

Al-Ghamdi

et al. 2023

J of Clinical Hypertension

View full text Add to dashboard Cite

Hyperkalemia is a frequent complication in patients with chronic kidney disease (CKD) or heart failure (HF) and associated with neuromuscular manifestations, changes in the electrocardiogram, and increased risk of mortality. While data on the prevalence and management of hyperkalemia in the gulf region are scarce, risk factors such as preference for potassium-rich foods (e.g., dates and dried fruits/vegetables), periods of intense fasting (e.g., Ramadan), and diabetes (an ancestor of CKD and HF) are common.Therefore, a panel of nephrologists and cardiologists from countries of the Gulf Cooperation Council (GCC) convened to collate and review available data on the prevalence, regional drivers, and current practice in the management of hyperkalemia in the region.Eventually, this review provides consensus recommendations on a balanced utilization of dietary and pharmacological options including new potassium binders for achieving and sustainably maintaining desirable serum potassium levels in countries of the GCC region. Alignment with regional habits and practice was a key aspect to facilitate the uptake of the recommendations into physicians' practice and patients' lives. K E Y W O R D Schronic kidney disease, heart failure, hyperkalemia, potassium binding INTRODUCTIONHyperkalemia is a frequent complication in chronic kidney disease (CKD) and heart failure (HF) patients, particularly those on reninangiotensin-aldosterone inhibitor (RAASi) therapy. 1,2 It is associ-All authors contributed equally to the preparation of this manuscript.

show abstract

Prevalence of Hyperkalemia among Hemodialysis Patients in Egypt

Cited by 22 publications

References 13 publications

Incidence of hyperkalemia in patients on maintenance hemodialysis and risk-factor analysis

Incidence of hyperkalemia in patients on maintenance hemodialysis and risk-factor analysis

Can Novel Potassium Binders Liberate People with Chronic Kidney Disease from the Low-Potassium Diet?

Prevalence and management of hyperkalemia in chronic kidney disease and heart failure patients in the Gulf Cooperation Council (GCC)

Contact Info

Product

Resources

About