Prevalence of hyperglycemia in pregnancy and influence of body fat on development of hyperglycemia in pregnancy among pregnant women in urban areas of Arusha region, Tanzania

Msollo, Safiness Simon; Martin, Haikael; Mwanri, Akwilina Wendelin; Petrucka, Pammla

doi:10.1186/s12884-019-2463-8

Cited by 22 publications

(24 citation statements)

References 41 publications

(50 reference statements)

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“…Along with other form of DM; child-bearing women are at a higher risk of developing DM in pregnancy [ 1 , 2 ]. This result in hyperglycemia in pregnancy is a medical condition resulting from either pre-existing diabetes or gestational diabetes which increased the risks of adverse birth outcomes [ 3 ]. DM in pregnancy was high (90%) in Low and Middle Income Countries (LMICs) where access to maternal and child health service is limited.…”

Section: Introductionmentioning

confidence: 99%

Adverse birth outcome and associated factors among diabetic pregnant women in Ethiopia: Systematic review and meta-analysis

et al. 2020

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Background The magnitude of adverse birth outcome among diabetic pregnant women is high in low-and-middle income countries, like Ethiopia. Precise epidemiological evidence is necessary to plan, evaluate and improve effective preventive measures. This systematic review and meta-analysis is the first to estimate the pooled prevalence of adverse birth outcome and associated factors among diabetic pregnant women in Ethiopia. Methods PubMed, Cochrane Library, Google Scholar, SCOPUS, Web of Science and PsycINFO, and article found in University online repository were accessed. Observational studies such as cross-sectional, case-control and prospective cohort reported using English language was involved. I2 statistic was used to check heterogeneity. Egger’s test and funnel plot were used to measure publication bias. Weighted inverse variance random effects model was also performed. Results Seven studies with 1,225 study participants were retrieved to estimate the pooled prevalence of adverse birth outcome and associated factors. The pooled prevalence of adverse birth outcome among diabetic pregnant women was 5.3% [95% CI; 1.61, 17.41]. Fasting blood glucose level above 100 mg/dl [Adjusted Odds ratio (AOR) = 10.51; 95% Confidence Interval (CI) = 5.90, 15.12], two hour post prandial glucose level above 120 mg/dl [AOR = 8.77; 95% CI = 4.51, 13.03], gestational age <37 completed week [AOR = 9.76; 95% CI = 5.29, 14.23], no ANC follow-up [AOR = 10.78; 95% CI = 6.12, 15.44], history of previous adverse outcomes [AOR = 3.47; 95% CI = 1.04, 5.90], maternal age < 30 years [AOR = 3.47; 95% CI = 1.04, 5.90], and illiteracy [AOR = 2.89; 95% CI = 0.81,4.97)] were associated factors of adverse birth outcome. Conclusions The pooled prevalence of adverse birth outcomes among diabetic pregnant women in Ethiopia was high. Child born from mothers who were illiterate, maternal age < 30 years, gestational age < 37 completed weeks, history of previous adverse birth outcomes and no ANC follow-up increased the risk of adverse birth outcome. Trial registration It is registered in PROSPERO data base: (PROSPERO 2020: CRD42020167734).

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Section: Introductionmentioning

confidence: 99%

Adverse birth outcome and associated factors among diabetic pregnant women in Ethiopia: Systematic review and meta-analysis

et al. 2020

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“…It is worth noting that women with hyperglycaemia are at high risk of hypertension, abortion/miscarriage, and/or a pregnancy resulting in a newborn that is large for gestational age (macrosomia), preterm birth, or neonatal death. Moreover, the researchers further stress that sedentary lifestyle, maternal height, dietary factors, cigarette smoking, and extreme pregnancy weight gain accompanied by high body fat accumulation could put women at risk of being diagnosed with hyperglycaemia in pregnancy [10]. Therefore, early detection of hyperglycaemia in pregnancy could provide relevant information to the attending gynaecologists to properly manage a particular pregnant woman.…”

Section: Introductionmentioning

confidence: 99%

Frequency and Factors Associated with Hyperglycaemia First Detected during Pregnancy at Itojo General Hospital, South Western Uganda: A Cross-Sectional Study

Kiiza

Kayibanda

Tumushabe

et al. 2020

Journal of Diabetes Research

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Background. Hyperglycemia in pregnancy complicates up to 30% of pregnancies in Africa, and this poses a major risk to both the mother and fetus. Although recommended by the World Health Organization (WHO), universal screening for hyperglycaemia in pregnancy is not routinely done in many of the hospital in low- and middle-income countries. This study sought to determine the frequency and factors associated with hyperglycaemia first detected in pregnancy at a general public hospital in South Western Uganda. Methods. We conducted this study at Itojo General Hospital (IGH) in Ntungamo District, South Western Uganda. The study followed a cross-sectional design that employed a systematic random sampling technique to identify potential study participants during the months of October to December 2019. Using a pretested questionnaire, data on sociodemographic and medical characteristics were collected on a sample of 307 pregnant women. Blood samples were collected and analyzed for hyperglycemia using random blood sugar and fasting blood sugar test results. Data generated were analyzed with appropriate statistical tests using the statistical package for social sciences (SPSS) version 26 (SPSS Inc., USA) at P<0.05. Results. The frequency of hyperglycaemia was found to be 15.6% among the study population. Multivariate analysis revealed that the ages of 19-30 years, peasantry, and multiparity with more than 5 live children and second trimester pregnancy were independent risk factors for the observed hyperglycaemia frequency. Conclusion. Our study reports new epidemiological information about the frequency and risk factors of hyperglycaemia in pregnancy from a selected Ugandan population. Our findings suggest an introduction of hyperglycaemia screening in the routine antenatal care package for proper maternal and neonatal health outcomes.

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“…Hyperglycaemia during pregnancy is associated with an increased risk of adverse maternal, foetal and neonatal outcomes, 16,76,77 and may occur because of either pre-pregnancy T1DM, T2DM or GDM. 76 The metabolic conditions associated with hyperglycaemia during pregnancy also contribute to health risks after birth in both mothers and babies, leading to a subsequent amplification of the pandemic of noncommunicable diseases. 9 Maternal hyperglycaemia in pregnancy leads to foetal hyperglycaemia, 78 and maternal insulin resistance shows a positive correlation with neonatal insulin resistance.…”

Section: Hyperglycaemiamentioning

confidence: 99%

Gestational diabesity and foetoplacental vascular dysfunction

et al. 2021

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Gestational diabetes mellitus (GDM) shows a deficiency in the metabolism of Dglucose and other nutrients, thereby negatively affecting the foetoplacental vascular endothelium. Maternal hyperglycaemia and hyperinsulinemia play an important role in the aetiology of GDM. A combination of these and other factors predisposes women to developing GDM with pre-pregnancy normal weight, viz. classic GDM. However, women with GDM and prepregnancy obesity (gestational diabesity, GDty) or overweight (GDMow) show a different metabolic status than women with classic GDM. GDty and GDMow are associated with altered l-arginine/nitric oxide and insulin/adenosine axis signalling in the human foetoplacental microvascular and macrovascular endothelium. These alterations differ from those observed in classic GDM. Here, we have reviewed the consequences of GDty and GDMow in the modulation of foetoplacental endothelial cell function, highlighting studies describing the modulation of intracellular pH homeostasis and the potential implications of NO generation and adenosine signalling in GDty-associated foetal vascular insulin resistance. Moreover, with an increase in the rate of obesity in women of childbearing 2 of 15 | CORNEJO Et al.

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Prevalence of hyperglycemia in pregnancy and influence of body fat on development of hyperglycemia in pregnancy among pregnant women in urban areas of Arusha region, Tanzania

Cited by 22 publications

References 41 publications

Adverse birth outcome and associated factors among diabetic pregnant women in Ethiopia: Systematic review and meta-analysis

Adverse birth outcome and associated factors among diabetic pregnant women in Ethiopia: Systematic review and meta-analysis

Frequency and Factors Associated with Hyperglycaemia First Detected during Pregnancy at Itojo General Hospital, South Western Uganda: A Cross-Sectional Study

Gestational diabesity and foetoplacental vascular dysfunction

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