Prevalence of Hyperandrogenic States in Late Adolescent and Young Women: Epidemiological Survey on Italian High-School Students

Gambineri, Alessandra; Fanelli, Flaminia; Prontera, Olga; Repaci, Andrea; Dalmazi, Guido Di; Zanotti, Laura; Pagotto, Uberto; Flacco, Maria Elena; Guidi, Jenny; Fava, Giovanni A.; Manzoli, Lamberto; Pasquali, Renato

doi:10.1210/jc.2012-3537

Cited by 43 publications

(39 citation statements)

References 35 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In line with these criteria, when the diagnosis was made by the presence of the complete phenotype, we found a higher prevalence of PCOS in girls with previous GHD than control subjects. These data are confirmed if we consider a recent epidemiological survey on the prevalence of PCOSfeatures in late adolescent and young women performed by Gambineri et al that showed a prevalence of MI of 10%-13%, clinical HA of about 16% and PCOS of < 15% [28]. To explain our data of prevalence the relationship between GH-IGF-1 axis and ovarian morphology and function must be taken into account.…”

Section: Ghd-pcos (Groupsupporting

confidence: 82%

Prevalence and clinical features of polycystic ovarian syndrome in adolescents with previous childhood growth hormone deficiency

Ciresi

Amato

Bianco

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

Background: Growth hormone (GH) plays a role in the regulation of ovarian function but there are limited data in women with GH deficiency (GHD). Our aim was to evaluate the features of polycystic ovarian syndrome (PCOS) in women with previous GHD. Methods: Data of 22 adolescents previously GH-treated (group A) were compared with those of 22 women with classical PCOS (group B) and 20 controls (group C). Results: Group A showed higher testosterone (p = 0.048) and prevalence of menstrual irregularities (p < 0.001) than group C. Compared to the group B, group A showed lower diastolic blood pressure (p = 0.004), degree of hirsutism (p = 0.005), testosterone (p = 0.003) and prevalence of polycsytic ovaries (POC) morphology (p = 0.024), with higher HDL-cholesterol (p = 0.035) and 17-β-estradiol (p = 0.009). Conclusions: Adolescents with previous GHD show a higher prevalence of PCOS than controls, but with milder metabolic and hormonal features than adolescents with classical PCOS. A careful long-term follow-up is advisable in these patients.

show abstract

Section: Ghd-pcos (Groupsupporting

confidence: 82%

Prevalence and clinical features of polycystic ovarian syndrome in adolescents with previous childhood growth hormone deficiency

Ciresi

Amato

Bianco

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

“…Available guidelines have suggested total testosterone concentrations >55 ng/dL (1.91 nmol/L) are likely consistent with hyperandrogenism. Further, Gambineri et al [169] defined hyperandrogenism during the follicular phase as total testosterone concentrations >42 ng/dL (1.45 nmol/L) using a LC-MS/MS assay. Because of the variability in the results of testosterone assays and the limited data on the normal development fluctuations in testosterone levels during adolescence, no clear cutoff testosterone concentrations can be given.…”

Section: B Diagnosismentioning

confidence: 99%

An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence

Ibáñez¹,

et al. 2017

Self Cite

View full text Add to dashboard Cite

This paper represents an international collaboration of paediatric endocrine and other societies (listed in the Appendix) under the International Consortium of Paediatric Endocrinology (ICPE) aiming to improve worldwide care of adolescent girls with polycystic ovary syndrome (PCOS)¹. The manuscript examines pathophysiology and guidelines for the diagnosis and management of PCOS during adolescence. The complex pathophysiology of PCOS involves the interaction of genetic and epigenetic changes, primary ovarian abnormalities, neuroendocrine alterations, and endocrine and metabolic modifiers such as anti-Müllerian hormone, hyperinsulinemia, insulin resistance, adiposity, and adiponectin levels. Appropriate diagnosis of adolescent PCOS should include adequate and careful evaluation of symptoms, such as hirsutism, severe acne, and menstrual irregularities 2 years beyond menarche, and elevated androgen levels. Polycystic ovarian morphology on ultrasound without hyperandrogenism or menstrual irregularities should not be used to diagnose adolescent PCOS. Hyperinsulinemia, insulin resistance, and obesity may be present in adolescents with PCOS, but are not considered to be diagnostic criteria. Treatment of adolescent PCOS should include lifestyle intervention, local therapies, and medications. Insulin sensitizers like metformin and oral contraceptive pills provide short-term benefits on PCOS symptoms. There are limited data on anti-androgens and combined therapies showing additive/synergistic actions for adolescents. Reproductive aspects and transition should be taken into account when managing adolescents.

show abstract

“…In general, for an assay using an extraction step, total testosterone concentrations >55 ng/dl are likely consistent with hyperandrogenism [18] . Gambineri et al [61] defined hyperandrogenism during the follicular phase as total testosterone concentrations >42 ng/dl using a LC-MS/MS assay.…”

Section: Recommendationsmentioning

confidence: 99%

The Diagnosis of Polycystic Ovary Syndrome during Adolescence

et al. 2015

View full text Add to dashboard Cite

dress a series of questions regarding the diagnosis of PCOS during adolescence including the following: clinical and biochemical evidence of hyperandrogenism, criteria for oligoanovulation and polycystic ovary morphology, diagnostic criteria to exclude other causes of hyperandrogenism and amenorrhea, role of insulin resistance, and intervention. Results and Conclusion: Features of PCOS overlap normal pubertal development. Hence, caution should be taken before diagnosing PCOS without longitudinal evaluation. However, treatment may be indicated even in the absence of a definitive diagnosis. While obesity, insulin resistance, and hyperinsulinemia are common findings in adolescents with hyperandrogenism, these features should not be used to diagnose PCOS among adolescent girls. © 2015 S. Karger AG, Basel Key WordsHyperandrogenism · Ovarian hyperandrogenism · Ovary · Polycystic ovary syndrome · Puberty Abstract Background/Aims: The diagnostic criteria for polycystic ovary syndrome (PCOS) in adolescence are controversial, primarily because the diagnostic pathological features used in adult women may be normal pubertal physiological events. Hence, international pediatric and adolescent specialty societies have defined criteria that have sufficient evidence to be used for the diagnosis of PCOS in adolescents. Methods: The literature has been reviewed and evidence graded to ad-

show abstract

Prevalence of Hyperandrogenic States in Late Adolescent and Young Women: Epidemiological Survey on Italian High-School Students

Abstract: This study provides for the first time a reliable assessment of the prevalence of hyperandrogenic states in late adolescent and young females and confirms that hyperandrogenic disorders originate at a young age.

Cited by 43 publications

References 35 publications

Prevalence and clinical features of polycystic ovarian syndrome in adolescents with previous childhood growth hormone deficiency

Prevalence and clinical features of polycystic ovarian syndrome in adolescents with previous childhood growth hormone deficiency

An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence

The Diagnosis of Polycystic Ovary Syndrome during Adolescence

Contact Info

Product

Resources

About