Prevalence of human T‐Cell lymphotropie virus infections in Germany

Schätzl, Hermann; Schwarzfischer, G; D, Rose; Gathof, Birgit; Weise, Wilhelm; Deinhardt, Friedrich; Helm, K. von der

doi:10.1002/jmv.1890430211

Cited by 6 publications

(5 citation statements)

References 8 publications

(3 reference statements)

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“…Based on the number of donations (n = 1,598,063) the prevalence is 0.00025%. The results obtained in our study are in contrast to those of Schätzl et al [22] who described a relatively high seroprevalence (0.021%) in a comparable donor population. This might be explained by their use of much less stringent interpretation criteria.…”

Section: Discussioncontrasting

confidence: 99%

“…At that time no HTLV infections were identified in these cohorts. In 1994 an HTLV-I/-II seroprevalence of 0.021% in Bavarian blood donors was reported [22], indicating that, based on confirmation with inhouse WB/RIPA and CDC criteria [23] for HTLV-I/-II positivity, 53 out of 248,000 donors were defined as HTLV-I/-II positive. According to these data, the seroprevalence seems to be rather high and would be comparable to that obtained in the USA [13].…”

Section: Introductionmentioning

confidence: 99%

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Detection of Rare Cases of HTLV-I and -II Infections and High Numbers of HTLV-Seroindeterminate Results in Bavarian Blood Donors

Fleischer¹,

Kücherer²,

Michel³

et al. 1999

Transfus Med Hemother

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Background: In order to evaluate the prevalence of human T-cell lymphotropic virus type I and II (HTLV-I/-II) infections in Germany, the Bavarian blood donor population was screened. Material and Methods:Between 1991 and 1994 around 1.5 million donations from about 375,000 blood donors of the Bavarian Red Cross (BRK) were tested for HTLV-I/-II in an antibody screening test. Sera repeatedly reactive in the screening test at the BRK blood bank were further assayed in additional enzyme-linked immunosorbent assays (ELISA), Western blot (WB) and radioimmunoprecipitation assay (RIPA). Selected donors were analyzed by polymerase chain reaction (PCR). Results:Only 4 HTLV-I/-II infections could be confirmed by WB and by RIPA, indicating a seroprevalence of 0.001%. Three positive donors were American soldiers and the fourth one was a German woman. Out of 609 sera reactive in at least two antibody screening tests, only 4 could be confirmed in WB as HTLV-I or -II positive. However, reactivity of these sera appears not to be related to an HTLV-I or -II infection, as shown by selected samples testing negative by RIPA and PCR. Conclusions:HTLV-I/-II seroprevalence in Bavarian blood donors is very low which implies that a general testing of all blood donations should not be recommended. However, donors with sexual partners from HTLV-endemic regions should be tested. Concerning serological diagnosis, we would suggest to modify the WHO-based interpretation criteria in countries with low HTLV prevalences: Only sera with antibodies to 1 or 2 Gag andthe 2 recombinant Env proteins should be considered HTLV positive.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of Rare Cases of HTLV-I and -II Infections and High Numbers of HTLV-Seroindeterminate Results in Bavarian Blood Donors

Fleischer¹,

Kücherer²,

Michel³

et al. 1999

Transfus Med Hemother

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“…Most HTLV infections in Europe are associated with individuals originating from endemic regions outside Europe. For Germany the published data on HTLV frequency in blood donors is conflicting [1–3]. This study was performed in an attempt to resolve these conflicting data.…”

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confidence: 99%

Human T‐cell lymphocytotrophic virus prevalence in German blood donors and ‘at‐risk’ groups

Nübling¹,

Nübling

Seifried

et al. 2001

Vox Sanguinis

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“…In Spain, screening for the virus has been mandatory for organ donors from endemic or high-risk areas since 2005 (20). It is not mandatory in Germany to screen blood and organ donors due to its low prevalence (7 cases per 10,000) (21)(22)(23)(24). Virus screening has been recommended for organ transplants in the United States since 2009 (25,26).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Human T-Lymphotropic Virus Type 1 in Brain-Dead Organ Donors

Nasri

Fakhim

Jafari-Sales

et al. 2022

Arch Clin Infect Dis

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Objectives: This study aimed to assess the prevalence of human T-lymphotropic virus type 1 (HTLV-1) among brain-dead organ donors at Masih Daneshvari Hospital in Tehran, Iran. Methods: By enzyme-linked immunosorbent assay (ELISA), 54 organ donors were screened for HTLV-1 virus in this descriptive cross-sectional study. Following that, Western blot confirmation was performed to confirm the HTLV-I infection. Results: Anti-HTLV-1 antibodies were detected in 2 (3.4%) cases out of 54 patients tested by ELISA. A western blot was performed in cases of positive results, but none of the subjects tested positive for HTLV-1 infection. Conclusions: The results of the present study indicated rare cases of HTLV-I infection in brain-dead organ donors. However, it is recommended that organ donors be investigated for the prevalence of this virus.

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Prevalence of human T‐Cell lymphotropie virus infections in Germany

Cited by 6 publications

References 8 publications

Detection of Rare Cases of HTLV-I and -II Infections and High Numbers of HTLV-Seroindeterminate Results in Bavarian Blood Donors

Detection of Rare Cases of HTLV-I and -II Infections and High Numbers of HTLV-Seroindeterminate Results in Bavarian Blood Donors

Human T‐cell lymphocytotrophic virus prevalence in German blood donors and ‘at‐risk’ groups

Prevalence of Human T-Lymphotropic Virus Type 1 in Brain-Dead Organ Donors

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