Prevalence of human papillomavirus (Papillomaviridae; Human papillomavirus) of high carcinogenic risk based on the results of screening of three anatomical loci in men stratified by sexual behavior and HIV status

Попова, А. А.; Домонова, Э. А.; Покровская, А. В.; Шипулина, О Ю; Покровский, В В

doi:10.36233/0507-4088-53

Cited by 1 publication

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“…The identified associations between specific SNPs and the risk of developing CC have significant implications for the development of screening programs aimed at identifying individuals at higher risk. Additionally, these findings play a crucial role in personalized management approaches for patients infected with high-risk HPV, particularly for individuals with a positive HIV status ( 8 ). The personalized approach takes into account individual genetic profiles and can contribute to more effective management and treatment strategies for HPV-associated cancers.…”

Section: Discussionmentioning

confidence: 99%

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The genetic variant rs55986091 HLA-DQB1 is associated with a protective effect against cervical cancer

et al. 2023

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IntroductionCervical cancer (CC) is a prevalent malignancy affecting women globally. The primary causative factor of CC is the high-risk oncogenic human papillomavirus (HR-HPV). However, it is noteworthy that not all women infected with HR-HPV develop cancer, indicating the potential involvement of genetic predisposition in the development of CC. This study aims to identify genetic risks and their distribution in groups of women with different epidemiological features of HR-HPV.Materials and methodsA comparison was conducted among four groups of women, comprising 218 HPV-negative women, 120 HPV-positive women, 191 women diagnosed with cervical intraepithelial neoplasia (CIN) grade 2 or 3, and 124 women diagnosed with CC. The analysis focused on four single nucleotide polymorphisms (SNPs): rs55986091 in HLA-DQB1, rs138446575 in TTC34, rs1048943 in CYP1A1, and rs2910164 in miRNA-146a.ResultsThe rs55986091-A allele exhibited a protective effect within the “CC” group when compared to the “HPV-Negative” group (OR = 0.4, 95% CI= 0.25-0.65) using a log-additive model. Additionally, similar protective effects were observed in the “CIN 2/3” group compared to the “HPV-Negative” group (OR = 0.47, 95% CI = 0.28-0.79).ConclusionThe data obtained emphasize the importance of developing PCR-based diagnostic kits for the identification of SNP alleles, particularly for rs55986091, among HR-HPV-positive women within the Russian population.

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Section: Discussionmentioning

confidence: 99%

“…Given the lengthy asymptomatic period, sexual transmission, and the impact on women of reproductive age, assessing the genetic risk of developing CC holds significant clinical importance. This is particularly relevant for high-risk groups, including women infected with HIV ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

The genetic variant rs55986091 HLA-DQB1 is associated with a protective effect against cervical cancer

et al. 2023

View full text Add to dashboard Cite

show abstract

Prevalence of human papillomavirus (Papillomaviridae; Human papillomavirus) of high carcinogenic risk based on the results of screening of three anatomical loci in men stratified by sexual behavior and HIV status

Abstract: научно-исследовательский институт эпидемиологии» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (Роспотребнадзор),

Cited by 1 publication

References 17 publications

The genetic variant rs55986091 HLA-DQB1 is associated with a protective effect against cervical cancer

The genetic variant rs55986091 HLA-DQB1 is associated with a protective effect against cervical cancer

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