Prevalence of human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer in imprisoned women worldwide: a systematic review and meta-analysis

Escobar, Nadia; Plugge, Emma

doi:10.1136/jech-2019-212557

Cited by 30 publications

(19 citation statements)

References 42 publications

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“…Diffuse and marked p16 expression usually indicates the presence of HPV infection in squamous cell carcinoma of the uterine cervix, pharynx, and esophagus [15,16,28]. Cao et al reported that the presence of HPV was significantly correlated with p16 immunoreactivity in esophageal squamous cell carcinoma and suggested the p16 immunoreactivity as a good marker for HPV infection [28].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, p16 protein overexpression is also considered a surrogate marker of oncogenic human papillomavirus (HPV) infection. HPV infection plays a pivotal role in carcinogenesis of oropharyngeal, uterine cervical, and perianal cancers [9,15,16]. Following the entry of virion via endocytosis, the virus establishes a persistent infection as a viral episome or integrates into the host genome [17].…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

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p16 in highly malignant esophageal carcinomas: the correlation with clinicopathological factors and human papillomavirus infection

et al. 2020

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Abstractp16 is generally considered to be a surrogate maker of human papillomavirus (HPV) infection and also a predictive marker of favorable clinical outcome of patients with squamous cell carcinoma of the oropharynx. p16 overexpression is also known to be induced by deregulation of RB1 in neuroendocrine carcinomas. In highly malignant esophageal neoplasms, however, the status of p16 has remained largely unknown. We immunolocalized p16 and Rb1 in 82 surgically resected esophageal high-grade squamous cell carcinomas (46 poorly differentiated and 36 basaloid squamous cell carcinomas) and 15 esophageal small-cell carcinomas in order to clarify the clinical and biological significance of p16. p16 immunoreactivity was detected in 7/82 (9%) high-grade squamous cell carcinomas and 15 (100%) small-cell carcinomas. p16 immunoreactivity was significantly associated with Rb1 protein loss in both groups (P < 0.001). HPV was detected in none of the p16-positive cases examined. Clinical outcome of the p16-positive high-grade squamous cell carcinomas was not different from that of the p16-negative counterparts (P = 0.687) but significantly better than those with the small-cell carcinomas (P = 0.023). p16 was therefore considered to be induced through an inactivation of the RB1 signaling pathway and not through HPV infection in highly malignant esophageal neoplasms. Nevertheless, patients’ clinical outcome of these neoplasms significantly differs; therefore, small-cell carcinomas have to be carefully differentiated from other neoplasms. In addition, p16 overexpression is not predictive of favorable clinical outcome in high-grade squamous cell carcinomas of the esophagus.

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Section: Discussionmentioning

confidence: 99%

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

p16 in highly malignant esophageal carcinomas: the correlation with clinicopathological factors and human papillomavirus infection

et al. 2020

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“…Cervical cancer (CC) is a familiar malignant tumor, which causes death and suffering to women around the world 1,2 . Besides human papillomavirus (HPV) infection, tobacco smoking, low socioeconomic status, immunosuppression, early age at first intercourse, and plenty of sexual partners are linked to higher risk of CC 3,4 . At present, surgery, radiation therapy, hormonal therapy, targeted therapy, and chemotherapy are the major strategies for cancer treatment, including CC 5 .…”

Section: Introductionmentioning

confidence: 99%

“…tobacco smoking, low socioeconomic status, immunosuppression, early age at first intercourse, and plenty of sexual partners are linked to higher risk of CC. 3,4 At present, surgery, radiation therapy, hormonal therapy, targeted therapy, and chemotherapy are the major strategies for cancer treatment, including CC. 5 The majority of early cancer is detected via refined detection technology, and the mortality of CC has apparently declined, and the prognosis rate has been elevated.…”

mentioning

confidence: 99%

Elevated microRNA‐130b‐5p or silenced ELK1 inhibits self‐renewal ability, proliferation, migration, and invasion abilities, and promotes apoptosis of cervical cancer stem cells

Huang

Luo

2020

IUBMB Life

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Cervical cancer (CC) is the most familiar gynecological malignancy. With the poor prognosis of CC patients, this study explored the effect of microRNA (miR)‐130b‐5p targeting ELK1 expression on self‐renewal ability and stemness of CC stem cells. The tissues of patients with CC or cervical benign lesions were collected. MiR‐130b‐5p and ELK1 expression was detected by reverse transcription quantitative polymerase chain reaction and western blot analysis. Human CC cell line Hela was cultured and the induced CC stem cells were introduced with miR‐130b‐5p mimic or silenced ELK1 to figure their roles in self‐renewal ability, stemness, colony formation, proliferation, migration, invasion abilities, and apoptosis of CC stem cells. Tumor growth was detected in nude mice in vivo. The targeting relationship between miR‐130b‐5p and ELK1 was analyzed using bioinformatic prediction and dual luciferase reporter gene assay. Decreased miR‐130b‐5p and elevated ELK1 existed in CC tissues of patients. Up‐regulated miR‐130b‐5p decreased ELK1 expression in CC stem cells. Elevated miR‐130b‐5p or silenced ELK1 inhibited self‐renewal ability and stemness, colony formation, proliferation, migration and invasion abilities, promoted apoptosis of CC stem cells, as well as decreased the weight and volume of tumor in nude mice. ELK1 was found to be targeted by miR‐130b‐5p. Overexpression ELK1 effectively reversed the cellular phenotypic changes and tumor formation in vivo caused by up‐regulation of miR‐130b‐5p. We conclude that up‐regulated miR‐130b‐5p or silenced ELK1 inhibits CC stem cell growth.

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“…In this respect, the human papillomavirus (HPV), the most important cause of cervical carcinoma, has been studied widely in numerous populations. Many of the risk factors for HPV infection (especially the high-risk type), such as cigarette use, immunosuppression, and low socioeconomic pro les are known to cluster in vulnerable populations, such as people incarcerated in prisons [6], and women in prison systems are likelier to have traded sexual favors for money or drugs [7]. This increases the risk of cervical intraepithelial neoplasia and cervical carcinoma among these women.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of High-risk Human Papillomavirus Infection Among Prisoners in the Nsawam Medium Security Prison, Ghana

Acheampong¹,

Effah

Amuah

et al. 2020

Preprint

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Background: The Ghana Prisons Service has a Health Directorate that ensures delivery of healthcare to people in their custody under the Ghana Association of Quasi Health Institution (GAQHI) which is one of the agencies under the Ministry of Health. Across Ghana, females comprise 1.2% of the entire prison population (n=15,463). Cervical cancer screening services are however nonexistent and the prevalence of cervical precancer is undocumented. Our aim was to determine the prevalence of high-risk HPV infection and associated cervical abnormalities during a cervical cancer screening outreach. Methods: After informed consent and counselling, women underwent a structured questionnaire-based interview. Responses were recorded directly into a Microsoft Excel spreadsheet. Inmates were co-tested for cervical pre-cancer by two trained nurses using dry brush cervical samples for 15 high risk HPV types using the AmpFire HPV test after which mobile colposcopy with the EVA system was performed. EVA images were reviewed by a gynecologist. Frequencies and percentages were used to describe categorical data while means and standard deviations or medians and interquartile ranges were used to describe continuous data. Results: The majority (75%) of the inmates were convicts with a median sentence of 5 years. Their mean age was 41.1 years (range, 19–97). Out of the 14% that had ever been screened for cervical cancer, 75% had only been screened once. The self-reported prevalence rate of HIV among the inmates was 13.1%, all of who were receiving treatment. The high-risk HPV prevalence rate was 47.6% in the general population of inmates and 63.6% among HIV positive inmates. Using the EVA system, 5(6%) had lesions on the cervix of which 3(3.6%) were treated with thermal coagulation and 2(2.4%) were treated with LEEP. The average age of high-risk HPV positive inmates was 37.8 years. These inmates were also more likely to have been in prison for a shorter duration. Conclusion: There is a high prevalence of high-risk HPV infection among women in custody. These women will benefit from structured cervical cancer prevention services, including treatment for abnormalities that are picked up during such screening.

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Prevalence of human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer in imprisoned women worldwide: a systematic review and meta-analysis

Cited by 30 publications

References 42 publications

p16 in highly malignant esophageal carcinomas: the correlation with clinicopathological factors and human papillomavirus infection

p16 in highly malignant esophageal carcinomas: the correlation with clinicopathological factors and human papillomavirus infection

Elevated microRNA‐130b‐5p or silenced ELK1 inhibits self‐renewal ability, proliferation, migration, and invasion abilities, and promotes apoptosis of cervical cancer stem cells

Prevalence of High-risk Human Papillomavirus Infection Among Prisoners in the Nsawam Medium Security Prison, Ghana

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