Prevalence of Human Papillomavirus (HPV) in Oesophageal Squamous Cell Carcinoma in Relation to Anatomical Site of the Tumour

Löfdahl, Hedvig E.; Du, Juan; Näsman, Anders; Andersson, Emilia; Rubio, Carlos A.; Lu, Yunxia; Ramqvist, Torbjörn; Dalianis, Tina; Lagergren, Jesper; Dahlstrand, Hanna

doi:10.1371/journal.pone.0046538

Cited by 30 publications

(39 citation statements)

References 25 publications

(27 reference statements)

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“…Variations in sampling methods, demographic and ethnic factors, anatomic sites, and methods used for viral detection have all been suggested as potential causes of these discrepancies. IHC measures of HPV activity in cervical and head and neck cancer were used to analyze the expression of the surrogate marker p16 INK4a 15. Consequently, detection of the HPV16 oncoprotein E6 was utilized as a surrogate marker in the current study to detect HPV infection.…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus 16 infection predicts poor outcome in patients with esophageal squamous cell carcinoma

Xi¹,

Zhang²,

Chen³

et al. 2015

OTT

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BackgroundPrevious studies indicate that human papillomavirus 16 (HPV16) infection plays a pivotal role in the etiology of esophageal squamous cell carcinoma (ESCC). We aim to detect the influence of HPV16 infection on ESCC patient prognosis.Patients and methodsImmunohistochemical staining for HPV16 E6 oncoprotein, the low-affinity p75 neurotrophin receptor (p75NTR), and phosphatidylinositol 3-kinase (PI3K) was performed on 103 archived surgical specimens from patients with ESCC and 54 control samples from patients with benign esophageal tumor or inflammatory lesions. All patients were from the Shaan Xi Province, People’s Republic of China.ResultsHPV16 E6 expression was significantly higher in the ESCC group (P<0.05). HPV16 E6 expression was significantly higher in men than in women (P<0.05). p75NTR expression was higher in those aged >56 years (P<0.05). PI3K expression was higher in those with a more advanced histopathological grade (P<0.05). There was a positive correlation between HPV16 E6 and p75NTR expression (r=0.547, P<0.001) and between p75NTR and PI3K expression (r=0.364, P<0.001). In 100 evaluable patients, the 5-year overall survival (OS) rate was 11%. In patients with ESCC, HPV16 E6 and PI3K expression were negatively correlated with the 3-year OS (P<0.05), 5-year OS (P<0.05), and progression-free survival (P<0.05).ConclusionHPV16 infection likely contributes to the etiology of ESCC patients in Shaan Xi, People’s Republic of China. HPV16 infection status and PI3K expression levels could be useful for predicting prognosis in patients with ESCC.

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Section: Discussionmentioning

confidence: 99%

Human papillomavirus 16 infection predicts poor outcome in patients with esophageal squamous cell carcinoma

Xi¹,

Zhang²,

Chen³

et al. 2015

OTT

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“…Eleven references included in the latest systematic review [20] were excluded from our analysis since they were recognized as duplicate publications, contained missing data about (HPV-positive) ESCC cases or had previously been counted twice. In the present literature search, we identified eight additional studies published from 1982 to 2011 [15,[26][27][28][29][30][31][32] and ten novel studies that have been published in the last 2 years [33][34][35][36][37][38][39][40][41][42] Altogether, until August 2013 a total of 11,310 cases of ESCC had been analyzed in 159 studies using various HPV detection methods (ranging from early histology assessments and IHC to modern DNA hybridization and amplification techniques) and a total of 30.3% (n = 3424) ESCC specimens tested HPV positive (table 1). As shown in tables 1 & 2, the highest HPV prevalence was generally observed in the regions having the highest incidence of ESCC.…”

Section: Update Of the Latest Systematic Review Of Studies Reporting mentioning

confidence: 99%

“…As shown in table 3, a total of 42 eligible studies investigating HPV prevalence/type distribution in patients with ESCC were published in the last 5 years [29][30][31][32][33][34][35][36][37][38][39][40][41][42]. Altogether, a total of 4014 patients with ESCC (from 17 counties, five continents) were tested using various HPV molecular assays, ranging from commercial Our results clearly showed that prophylactic vaccination with currently available HPV vaccines could theoretically prevent more that 70% of all α-PV DNA-positive ESCC, a figure similar to cervical cancer.…”

Section: Update Of the Latest Systematic Review Of Studies Reporting mentioning

confidence: 99%

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Role of Human Papillomaviruses in Esophageal Carcinoma: An Updated Systematic Review from 1982 to 2013

2014

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Tobacco, alcohol and betel quid are known etiological agents of esophageal squamous cell carcinoma (ESCC). A meta-analysis in 2012 and a literature update (1982–August 2013) identified 159 studies with a total of 11,310 ESCCs tested for the presence of human papillomaviruses (HPVs). HPV DNA was present in 30.3% of fESCCs, with substantial geographic differences. A recent meta-analysis of 21 case–control studies investigating the HPV–ESCC association showed that HPVs increase the risk of ESCC at least threefold. Vaccine-preventable HPV-16 and HPV-18 are the most commonly identified HPV types in ESCC in both low- and high-incidence settings. HPVs should now be seriously considered as etiological agents for at least a subset of ESCC, and more studies are needed to provide conclusive evidence that HPVs cause ESCC.

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“…Antunes et al [28] and Herbster et al [38] from Brazil as well as Koh et al [39] from the Korean Cancer Centre Hospital found that tests for HPV DNA were negative in all their samples. Lofdahl et al [40] set up a population-based study relating HPV infection to tumor site in patients diagnosed with ESCC in Stockholm County in Sweden in 1999-2006. They found that among 204 patients, 10% had tumors harboring HPV DNA, and tumors containing HPV were not overrepresented in the upper compared with the middle or lower third of the esophagus.…”

Section: Evidence Of a Negative Association Between Hpv And Esccmentioning

confidence: 99%

Viruses, Other Pathogenic Microorganisms and Esophageal Cancer

Liu

Bao

et al. 2015

Gastrointest Tumors

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Background: Esophageal cancer (EC) is the eighth most prevalent malignant tumor and the sixth leading cause of cancer mortality throughout the world. Despite the technical developments in diagnosis and treatment, the 5-year survival rate is still low. The etiology of EC remains poorly understood; multiple risk factors may be involved and account for the great variation in EC incidence in different geographic regions. Summary: Infection with carcinogenetic pathogens has been proposed as a risk factor for EC. This review explores the recent studies on the association of human papillomavirus (HPV), Epstein-Barr virus (EBV), Helicobacter pylori and esophageal bacterial biota with EC. Key Message: Among the above-mentioned pathogens, HPV most likely contributes to esophageal squamous cell carcinoma (ESCC) in high-risk populations. New techniques are being applied to studies on the role of infection in EC, which will inevitably bring novel ideas to the field in the near future. Practical Implications: Multiple meta-analyses support the finding of a higher HPV detection rate in regions associated with high risk for ESCC compared to low-risk areas. A potential role of HPV in the rise of esophageal adenocarcinoma (EAC) was proposed recently. However, further studies are required before a firm conclusion can be drawn. Less work has been done in studying the association between EBV and ESCC, and the results are quite controversial. H. pylori infection is found to be inversely related to EC, which is probably due to the reduced incidence of gastroesophageal reflux disease. Analysis of the esophageal bacterial biota revealed distinct clusters of bacteria in normal and diseased esophagi. A type II microbiome rich in Gram-negative bacteria potentially contributes to EAC by inducing chronic inflammation. Novel findings from such studies as these may benefit public health by justifying anti-infection measures to prevent EC.

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Prevalence of Human Papillomavirus (HPV) in Oesophageal Squamous Cell Carcinoma in Relation to Anatomical Site of the Tumour

Cited by 30 publications

References 25 publications

Human papillomavirus 16 infection predicts poor outcome in patients with esophageal squamous cell carcinoma

Human papillomavirus 16 infection predicts poor outcome in patients with esophageal squamous cell carcinoma

Role of Human Papillomaviruses in Esophageal Carcinoma: An Updated Systematic Review from 1982 to 2013

Viruses, Other Pathogenic Microorganisms and Esophageal Cancer

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