Prevalence of human papillomavirus among Wenzhou women diagnosed with cervical intraepithelial neoplasia and cervical cancer

Abstract

BackgroundHuman papillomavirus (HPV) is associated with an increased risk of cervical cancer. Using a vaccine to prevent HPV infections could be a cost-effective strategy to decrease the incidence of cervical cancer. Learning about the characteristics of CIN patients with HPV infection in Wenzhou is a key step in guiding the use of HPV vaccines and screening for cervical cancer.MethodsWe undertook a retrospective analysis including 2612 women who were treated in the Department of Gynecology and Obstetrics from Jan 2016 to Nov 2017. All of the patients were examined by HPV testing and histology.ResultsThe prevalence of HR-HPV among women with cervical intraepithelial lesions aged 65–69 years (38.8%) was significantly higher than that of the other age groups. The percentage of patients diagnosed with HPV-positive HSIL progressively increased with age to a maximum of 18.0% in the group of 40 to 44 years of age. HPV 16, 52, and 58 were the three most dominant genotypes among these women, and single infections (950, 73.3%) were more common than multiple infections (346, 26.7%). Compared to cervicitis, the odds ratios (ORs) for LSIL associated with HPV 33, 52, 16 and HPV 58 infection were 5.98, 3.91, 3.65, 3.65, and 3.188, respectively; for HSIL associated with HPV 16, 33, 58 and HPV 31 were 9.30, 7.68, 5.97, and 4.21, respectively. In LSIL, the frequencies of HR-HPV 52,16,58,18 were 19.3,18.2,10.9, and 7.8%, respectively.ConclusionOur study provides important data about the HPV genotype distribution and its correlation with cervical intraepithelial lesions in the Wenzhou population.

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“…This genotype was also the most persistent in all cancerous and precancerous conditions. The prevalence of HPV 16 over the other genotypes (among these studies) is in agreement with previous reports from different geographical areas [20,21,22]. Few studies have been conducted in Africa to assess the distribution of HPV genotypes (HPV 58 was common in the current studies).…”

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“…In 2018, clinical, epidemiological, and clinicopathological studies reported HPV58 to be the second or third most predominant genotype in precancerous CIN I, II, III, and ICC lesions, a higher grade of squamous intraepithelial or cell carcinoma, and adenocarcinoma of HPV positive patients in different geographical regions of China [11]. Seven provinces of China have reported hrHPV-mediated cervical cancer incidences, namely, Guangdong, Liaocheng, Shanghai, Wenzhou, Wuhan, Southwestern China, and Western China [13,14,15,16,17,18,19]. Zhang et al [20] reported that the HPV16 (6.4%) and HPV58 (5.3%) genotypes were predominantly found in males who had recently been involved in sex, in Shanghai.…”