Prevalence of human papilloma virus and Epstein–Barr virus in tumorous and adjacent tissues of colorectal cancer in Iran

Tavakolian, Shaian; Goudarzi, Hossein; Eslami, Gita; Dayyani, Farnaz; Kazeminezhad, Behrang; Faghihloo, Ebrahim

doi:10.1016/j.genrep.2020.100774

Cited by 8 publications

(8 citation statements)

References 44 publications

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“…However, it is indeed surprising to note that only one out of the nine studies from Iran reported a high prevalence of HPVs (83%) [ 53 ]. The remaining majority of the studies report a relatively lower prevalence within the range of 0% to 23% [ 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. Similarly, most other studies from the MENA region report a lower prevalence of HPV in CRC.…”

Section: Discussionmentioning

confidence: 99%

Coinfection of HPVs Is Associated with Advanced Stage in Colorectal Cancer Patients from Qatar

et al. 2023

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High-risk human papillomaviruses (HPVs) are considered risk factors in the origin of several human malignancies, such as breast, cervical, head and neck, as well as colorectal cancers. However, there are no data reported on the HPV status in colorectal cancer in the State of Qatar. Therefore, we herein examined the presence of high-risk HPVs (16, 18, 31, 33, 35, 45, 51, 52, and 59), using polymerase chain reaction (PCR) in a cohort of 100 Qatari colorectal cancer patients, and their association with tumor phenotype. We found that high-risk HPV types 16, 18, 31, 35, 45, 51, 52, and 59 were present in 4, 36, 14, 5, 14, 6, 41, and 17% of our samples, respectively. Overall, 69 (69%) of the 100 samples were HPV positive; among these, 34/100 (34%) were positive for single HPV subtypes, while 35/100 (35%) of the samples were positive for two or more HPV subtypes. No significant association was noted between the presence of HPV and tumor grade, stage, or location. However, the presence of coinfection of HPV subtypes strongly correlated with advanced stage (stage 3 and 4) colorectal cancer, indicating that the copresence of more than one HPV subtype can significantly worsen the prognosis of colorectal cancer. The results from this study imply that coinfection with high-risk HPV subtypes is associated with the development of colorectal cancer in the Qatari population.

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Section: Discussionmentioning

confidence: 99%

Coinfection of HPVs Is Associated with Advanced Stage in Colorectal Cancer Patients from Qatar

et al. 2023

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“…E7 oncoprotein promotes cell cycle progression by releasing E2F through pRb ubiquitination. The released E2F causes the transcription of cyclin E, cyclin A and p16 factors as Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors and cell entry into the S phase [ 23 ]. E7 can also inhibit the effect of p21 and p27, an inhibitor of CDK, to promote cell proliferation [ 24 ].…”

Section: Hpv Oncogenesismentioning

confidence: 99%

The complexity of human papilloma virus in cancers: a narrative review

Sofiani

Veisi

Rukerd

et al. 2023

Infect Agents Cancer

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Among human tumorigenic viruses, the role of Human papillomavirus (HPV) has been proven as one of the most important oncoviruses that are associated with a large number of cancers. Most cancers of the genital area such cervical and anal cancer as are caused by HPV, and in many other cancers, such as colorectal, gastric, liver, esophageal, urinary bladder, and head and neck cancers, it is considered as one of the important risk factors. Our search was conducted for published researches between 2000 and 2022 by using several international databases including Scopus, PubMed, and Web of Science as well as Google scholar. We also evaluated additional evidence from relevant published articles. It has been demonstrated that HPV can promote tumorigenesis via focusing on genes, proteins, and signaling pathways, by using E6 and E7 oncoproteins and inhibiting two crucial tumor suppressors, P53 and Rb. The following study was performed to investigate different malignant cancers under the influence of HPV infection and changes in molecular factors caused by HPV infection.

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“…Additionally, a moderate HPV prevalence (12–44%) was reported in CRC samples from countries in the Middle East region. 32 , 47–51 In contrast, a few studies have reported low HPV prevalence (<10%), 37 , 52–56 while some did not detect the presence of HPV in CRC. 57–60 The variation in HPV positivity rates reported in different studies is partly due to focusing on the presence of specific types of HPV, mostly 16 and 18.…”

Section: Discussionmentioning

confidence: 94%

Incidence and association of high-risk HPVs and EBV in patients with advanced stages of colorectal cancer from Qatar

Fernandes,

Gupta,

Murshed

et al. 2023

Human Vaccines & Immunotherapeutics

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High-risk Human Papillomaviruses (HPVs) and Epstein – Barr virus (EBV) are present and involved in several types of human carcinomas, including cervical and, head and neck cancers. Nevertheless, their presence and association in the pathogenesis of colorectal cancer is still nascent. The current study explored the association between the high-risk HPVs and EBV and tumor phenotype in colorectal cancers (CRCs) in the Qatari population. We found that high-risk HPVs and EBV are present in 69/100 and 21/100 cases, respectively. Additionally, 17% of the cases showed a copresence of high-risk HPVs and EBV, with a significant correlation only between the HPV45 subtype and EBV ( p = .004). While the copresence did not significantly associate with clinicopathological characteristics, we identified that coinfection with more than two subtypes of HPV is a strong predictor of advanced stage CRC, and the confounding effect of the copresence of EBV in such cases strengthens this association. Our results indicate that high-risk HPVs and EBV can co-present in human CRCs in the Qatari population where they could plausibly play a specific role in human colorectal carcinogenesis. However, future studies are essential to confirm their copresence and synergistic role in developing CRCs.

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Prevalence of human papilloma virus and Epstein–Barr virus in tumorous and adjacent tissues of colorectal cancer in Iran

Cited by 8 publications

References 44 publications

Coinfection of HPVs Is Associated with Advanced Stage in Colorectal Cancer Patients from Qatar

Coinfection of HPVs Is Associated with Advanced Stage in Colorectal Cancer Patients from Qatar

The complexity of human papilloma virus in cancers: a narrative review

Incidence and association of high-risk HPVs and EBV in patients with advanced stages of colorectal cancer from Qatar

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