Prevalence of human cosaviruses in Tunisia, North Africa

Rezig, Dorra; Farhat, Essia Ben; Touzi, Henda; Meddeb, Zina; Salah, Afif Ben; Triki, Henda

doi:10.1002/jmv.24076

Cited by 16 publications

(7 citation statements)

References 11 publications

(21 reference statements)

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“…Our data showed that the detection rate of CosV in diarrheal children (1%) was lower than observed in China or Brazil, where they were reported in diarrheal children in 2.8% and 3.6% of patients [ 33 , 34 ] , respectively. CosV has been previously reported in up to 33.0% of healthy Tunisian subjects or suffering from non-polio acute flaccid paralysis, most of them being children <6 years old [ 35 ] . However, the difference in detection rates is due to different natures of the two cohorts.…”

Section: Resultsmentioning

confidence: 99%

Cosavirus, Salivirus and Bufavirus in Diarrheal Tunisian Infants

et al. 2016

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Three newly discovered viruses have been recently described in diarrheal patients: Cosavirus (CosV) and Salivirus (SalV), two picornaviruses, and Bufavirus (BuV), a parvovirus. The detection rate and the role of these viruses remain to be established in acute gastroenteritis (AGE) in diarrheal Tunisian infants. From October 2010 through March 2012, stool samples were collected from 203 children <5 years-old suffering from AGE and attending the Children’s Hospital in Monastir, Tunisia. All samples were screened for CosV, SalV and BuV as well as for norovirus (NoV) and group A rotavirus (RVA) by molecular biology. Positive samples for the three screened viruses were also tested for astrovirus, sapovirus, adenovirus, and Aichi virus, then genotyped when technically feasible. During the study period, 11 (5.4%) samples were positive for one of the three investigated viruses: 2 (1.0%) CosV-A10, 7 (3.5%) SalV-A1 and 2 (1.0%) BuV-1, whereas 71 (35.0%) children were infected with NoV and 50 (24.6%) with RVA. No mixed infections involving the three viruses were found, but multiple infections with up to 4 classic enteric viruses were found in all cases. Although these viruses are suspected to be responsible for AGE in children, our data showed that this association was uncertain since all infected children also presented infections with several enteric viruses, suggesting here potential water-borne transmission. Therefore, further studies with large cohorts of healthy and diarrheal children will be needed to evaluate their clinical role in AGE.

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Section: Resultsmentioning

confidence: 99%

Cosavirus, Salivirus and Bufavirus in Diarrheal Tunisian Infants

et al. 2016

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“…Since cosaviruses have been detected in both healthy and symptomatic individuals and case-cohort studies are still missing, the etiological role remains unclear. To determine whether cosaviruses are the causative agents of neurological or gastrointestinal disorders or act as bystanders needs further investigation [43,44].…”

Section: Discussionmentioning

confidence: 99%

Detection and Characterization of Human Enteroviruses, Human Cosaviruses, and a New Human Parechovirus Type in Healthy Individuals in Osun State, Nigeria, 2016/2017

Osundare

Opaleye

Akindele

et al. 2019

Viruses

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Human enteroviruses and human parechoviruses are associated with a broad range of diseases and even severe and fatal conditions. For human cosaviruses, the etiological role is yet unknown. Little is known about the circulation of non-polio enteroviruses, human parechoviruses, and human cosaviruses in Nigeria. A total of 113 stool samples were collected from healthy individuals in Osun State between February 2016 and May 2017. RT-PCR assays targeting the 5′ non-coding region (5′ -NCR) were used to screen for human enteroviruses, human parechoviruses, and human cosaviruses. For human enteroviruses, species-specific RT-PCR assays targeting the VP1 regions were used for molecular typing. Inoculation was carried out on RD-A, CaCo-2, HEp-2C, and L20B cell lines to compare molecular and virological assays. Ten samples tested positive for enterovirus RNA with 11 strains detected, including CV-A13 (n = 3), E-18 (n = 2), CV-A20 (n = 1), CV-A24 (n = 1), EV-C99 (n = 1), and EV-C116 (n = 2). Three samples tested positive for human parechovirus RNA, and full genome sequencing on two samples allowed assignment to a new Parechovirus A type (HPeV-19). Thirty-three samples tested positive for cosavirus with assignment to species Cosavirus D and Cosavirus A based on the 5′-NCR region. Screening of stool samples collected from healthy individuals in Nigeria in 2016 and 2017 revealed a high diversity of circulating human enteroviruses, human parechoviruses, and human cosaviruses. Molecular assays for genotyping showed substantial benefits compared with those of cell-culture assays.

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“…These three novel viruses were isolated from patients with different clinical and epidemiologic patterns ( 4 ). They were isolated from patients with GE ( 6 , 16 ) and neurological disorders ( 17 – 19 ). While GE is a threat to global health, the causative agents of many cases still remained unclear ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Global Status of Bufavirus, Cosavirus, and Saffold Virus in Gastroenteritis: A Systematic Review and Meta-Analysis

2022

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Background: Bufavirus (BuV), Human Cosavirus (HCoSV), and Saffold (SAFV) virus are three newly discovered viruses and have been suggested as possible causes of gastroenteritis (GE) in some studies. The aim of the present study was to estimate the overall prevalence of viruses and their association with GE.Methods: A comprehensive systematic search was conducted in Scopus, Web of Science, PubMed, and Google scholar between 2007 and 2021 to find studies on the prevalence of BuV, HCoSV, and SAFV viruses.Result: Meta-analysis of the 46 included studies showed the low prevalence of BuV (1.%, 95% CI 0.6–1.5%), HCoSV (0.8%, 95% CI 0.4–1.5%), and SAFV (1.9%, 95% CI 1.1–3.1%) worldwide. Also, no significant association between these viruses and GE was observed. BuV was isolated from patients with GE in Africa, while SAFV was more common in Europe. BuV1 and BuV2 have the same prevalence between the three identified genotypes of BuV. HCoSV-C was the most prevalent genotype of HCoSV, and SAFV2 was the commonest genotype of SAFV. All of these viruses were more prevalent in children older than 5 years of age.Conclusion: This was the first meta-analysis on the prevalence and association of BuV, HCoSV, and SAFV with GE. While no significant association was found between infection with these viruses and GE, we suggest more studies, especially with case-control design and from different geographical regions in order to enhance our knowledge of these viruses.

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Prevalence of human cosaviruses in Tunisia, North Africa

Cited by 16 publications

References 11 publications

Cosavirus, Salivirus and Bufavirus in Diarrheal Tunisian Infants

Cosavirus, Salivirus and Bufavirus in Diarrheal Tunisian Infants

Detection and Characterization of Human Enteroviruses, Human Cosaviruses, and a New Human Parechovirus Type in Healthy Individuals in Osun State, Nigeria, 2016/2017

Global Status of Bufavirus, Cosavirus, and Saffold Virus in Gastroenteritis: A Systematic Review and Meta-Analysis

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