Prevalence of home parenteral nutrition in children

Wiskin, Anthony E.; Russell, Rachel; Barclay, Andrew; Thomas, J. Earl; Batra, Akshay

doi:10.1016/j.clnesp.2020.12.029

Cited by 18 publications

(19 citation statements)

References 8 publications

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“…Así, algunos estudios llevados a cabo en diferentes países europeos, sobre la prevalencia de la NPD en niños con insuficiencia intestinal crónica, han informado cifras en los <18 años de 9,56 casos por millón de habitantes, como es el caso de los Países Bajos en 2013 o de Italia con una prevalencia en los ≤19 años de 14,12 pacientes por millón de habitantes, Estudio epidemiológico de la prevalencia del síndrome de intestino corto en España siendo en su mayoría (58%) causados por SIC (22,23) . En 2019, un estudio en Reino Unido publicó una prevalencia de NPD de 30 niños por millón, el 48% de ellos estaban diagnosticados de SIC (24) . En España, el último informe publicado del grupo NADYA, en 2019, presentó datos de NPD siendo el SIC el primer motivo de indicación terapéutica tanto en niños (51,6%) como en adultos (37,3%) (13) .…”

Section: Discussionunclassified

Estudio epidemiológico de la prevalencia del síndrome de intestino corto en España

Lozano

Oller-Arlandis²,

Domingo-Pueyo³

2022

Hosp Domic

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Introducción: El síndrome de intestino corto (SIC) es una alteración de la absorción de los nutrientes causado, frecuentemente, por la resección quirúrgica del intestino delgado. El espectro de las manifestaciones clínicas varía ampliamente, según la longitud remanente del intestino delgado. Objetivo: Conocer la prevalencia de los casos de SIC en España en el año 2018. Método: Estudio observacional transversal multicéntrico, de base poblacional, mediante cuestionario telemático en el que se recogen los datos de los pacientes diagnosticados de SIC en 2018. Resultados: De un total de 541 centros sanitarios seleccionados, del Catálogo Nacional de Hospitales del Ministerio de Sanidad, participaron 101 hospitales. Con los datos obtenidos, la prevalencia de SIC en España se estimaría en 4,18 pacientes por millón de habitantes durante ese año. Conclusiones: La falta de participación dificulta obtener resultados concluyentes, lo que resulta mucho más importante cuando se trata de problemas de salud poco prevalentes.

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Section: Discussionunclassified

Estudio epidemiológico de la prevalencia del síndrome de intestino corto en España

Lozano

Oller-Arlandis²,

Domingo-Pueyo³

2022

Hosp Domic

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“…In fact, a 360-degree multidisciplinary evaluation of the patient state is key to orienting management. Within an IRP, liver-sparing PN is commenced to lower the risk of the alarming IFALD [4][5][6]. Moreover, oral feeding is usually preferred since it more closely resembles the natural physiology, stimulating the bowel mucosa, enhancing adaptation and promoting brain learning.…”

Section: Intestinal Rehabilitation Programmentioning

confidence: 99%

“…The overall survival has increased over the last decades, even with significant losses of bowel length [3]. This has mainly been due to improved overall care, new total parenteral nutrition (TPN) formulas, and improved surgical techniques [4,5]. However, TPN complications are still a challenge for rehabilitation teams and long-term parenteral nutrition (PN) may lead to intestinal failure-associated liver disease (IFALD) [6,7].…”

Section: Introductionmentioning

confidence: 99%

Current Surgical Concepts and Indications in the Management of the Short Bowel State: A Call for the Use of Multidisciplinary Intestinal Rehabilitation Programs

et al. 2021

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The mainstay of management for short bowel syndrome (SBS) is to promote access to the best quality of care provided by the intestinal rehabilitation program (IRP) in specialized centres. When treating SBS patients, the main goal is to minimize disease-associated complications, as well as achieve enteral autonomy. Surgical strategies should be selected cautiously upon the actual state of the bowel with respect to what it is clinically relevant for that specific patient. To this aim, a personalized and multidisciplinary approach for such a complex syndrome is needed.

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“…Due to the considerable progress in the field of PN, this feeding route is widely used in infants and children for short- or long-term periods, at the hospital or at home, depending on different pathological situations [ 8 , 9 , 10 ]. PN is not only particularly important for preterm neonates who do not tolerate enteral feeds due to their gut immaturity and associated congenital or acquired gut disorders, including short bowel syndrome (SBS) {after massive intestinal resection due to necrotizing enterocolitis (NEC), intestinal atresia or gastroschisis}, but also for other patients affected by intestinal mucosal diseases (congenital diarrheal disorders), inflammatory bowel disease (IBD) or disorders of intestinal dysmotility (pediatric intestinal pseudo-obstruction) [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders

et al. 2022

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Parenteral nutrition (PN) is a life-saving therapy providing nutritional support in patients with digestive tract complications, particularly in preterm neonates due to their gut immaturity during the first postnatal weeks. Despite this, PN can also result in several gastrointestinal complications that are the cause or consequence of gut mucosal atrophy and gut microbiota dysbiosis, which may further aggravate gastrointestinal disorders. Consequently, the use of PN presents many unique challenges, notably in terms of the potential role of the gut microbiota on the functional and clinical outcomes associated with the long-term use of PN. In this review, we synthesize the current evidence on the effects of PN on gut microbiome in infants and children suffering from diverse gastrointestinal diseases, including necrotizing enterocolitis (NEC), short bowel syndrome (SBS) and subsequent intestinal failure, liver disease and inflammatory bowel disease (IBD). Moreover, we discuss the potential use of pre-, pro- and/or synbiotics as promising therapeutic strategies to reduce the risk of severe gastrointestinal disorders and mortality. The findings discussed here highlight the need for more well-designed studies, and harmonize the methods and its interpretation, which are critical to better understand the role of the gut microbiota in PN-related diseases and the development of efficient and personalized approaches based on pro- and/or prebiotics.

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Prevalence of home parenteral nutrition in children

Cited by 18 publications

References 8 publications

Estudio epidemiológico de la prevalencia del síndrome de intestino corto en España

Estudio epidemiológico de la prevalencia del síndrome de intestino corto en España

Current Surgical Concepts and Indications in the Management of the Short Bowel State: A Call for the Use of Multidisciplinary Intestinal Rehabilitation Programs

Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders

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