Prevalence of HLA sensitization in female apheresis donors

Abstract

These findings confirm the hypothesis that multiparous women (> or = 3 pregnancies) represent an increased potential risk for TRALI. However, the exclusion of multiparous plateletpheresis donors would eliminate one-third of our female donor pool. Screening such donors for HLA sensitization may represent the optimal approach for identifying donors at risk for causing TRALI, but this still would result in the deferral of 8 percent of female plateletpheresis donors. At present, prospective screening to identify donors at risk for causing TRALI is not justified.

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

“…The higher incidence of HLA/HNA antibodies in female donors may be explained by alloimmunization during pregnancies. 41 Given the association of female donors with TRALI, the United Kingdom National Blood Service deferred women from plasma donation since 2003. Since For personal use only.…”

“…In line with previous reports, we show an association between the presence of antibodies in the products and sex of the donor. 41 Of interest, excluding female donors for production of FFP as part of the National Blood Bank For personal use only. on April 5, 2019.…”

Detection and Identification of Platelet-Associated Alloantibodies by a Solid-Phase Modified Antigen Capture Elisa (MACE) Technique and Its Correlation to Platelet Refractoriness in Multi platelet Concentrate Transfused Patients

“…Refractoriness does not necessarily imply alloimmunization. Indeed, the major cause of refractoriness to platelet transfusion are nonimmune factors that result in shortened platelet survival and markedly decreased platelet recoveries in patients who receive multiple transfusions [1,2,6,19].…”

“…Non-immunological factors are responsible in 72-88 % of cases of refractoriness in patients with haematological diseases, while HLA antibodies in 25-39 % [6,12]. Presence of HLA antibodies in the transfusion recipient are Fig.…”

The pathogenesis of transfusion‐related acute lung injury (TRALI)

“…Therefore, in late 2003 the UK National Blood Service introduced a policy of using male donors whenever possible to produce fresh frozen plasma (Chapman et al, 2006). However, the exclusion of multiparous female donors would result in the loss of approximately of 30% of donors (Densmore et al, 1999;Webert & Blajchman, 2003). For apheresis donors, the disqualification of all multiparous donors seems to be disproportionate and initiating screening of parous female donors for the presence of leucocyte antibodies appears to be more reasonable.…”