Prevalence of HIV, HCV and HBV in Central Asia and the Caucasus: A systematic review

Davlidova, Salima; Haley-Johnson, Zoë; Nyhan, Kate; Farooq, Ayesha; Vermund, Sten H.; Ali, Syed

doi:10.1016/j.ijid.2020.12.068

Cited by 34 publications

(34 citation statements)

References 56 publications

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“…Clinico-demographic characteristics of donors, recipients, and outcomes were described in this paper. Our data showed that the main cause of ESLD among our patients was HBV, which accords with a systematic review indicating that Kazakhstan has the highest prevalence of HBV in central Asia [ 9 ]. Among a total of 64 liver transplantations, 53 recipients received a liver graft from living donors.…”

Section: Discussionsupporting

confidence: 91%

Liver Transplantation: A 10-Year Low-Volume Transplant Center Experience in Kazakhstan

et al. 2021

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Background Liver transplantation is considered to be the best available treatment option for patients with liver failure. In Kazakhstan, the liver transplantation program was established a decade ago. In this study, we analyzed a low-volume transplant center experience of liver transplantation in Kazakhstan. Material/Methods Clinical data of the 64 consecutive liver transplantations from deceased and living donors between 2010 and 2020 were retrieved from electronic records. All data were retrospectively analyzed. Results A total of 64 liver transplantations, 11 from deceased donors and 53 from living donors, were carried out in our center between 2010 and 2020. The mean age of the recipient was 44 years, 53% were female, and 47% were male. Hepatitis B+hepatitis D infection was the most common cause of end-stage liver disease (21 cases; 32.8%). The overall patient survival rates for 1, 3, and 5 years were 75%, 69.5%, and 59.6%, respectively, for recipients of a liver transplant from a living donor and 54.5%, 45.5%, and 39% for recipients of a liver transplant from a deceased donor. Conclusions Our clinical outcomes had a high rate of biliary and vascular complications that led to a low survival rate of the recipients. Starting the transplant program in Kazakhstan faced various challenges. In the early period, most transplantations were performed in collaboration with or under the guidance of transplant teams from Russia, Turkey, and South Korea. Improving surgical techniques and protocols of pre- and posttransplantation management could reduce the complications after transplantation.

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Section: Discussionsupporting

confidence: 91%

Liver Transplantation: A 10-Year Low-Volume Transplant Center Experience in Kazakhstan

et al. 2021

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“…In the former Soviet countries, tuberculosis, drug use, and HIV infection were major public problems ( 50 – 52 ), which probably generated the pronounced increasing trends observed in Georgia, Armenia, and Kazakhstan. For example, a high prevalence of HIV was reported among IDU (>30%) in Kazakhstan ( 53 ). Furthermore, 35.8% of people living with HIV did not report good health-related quality of life, and the adverse factors included depression, coinfection with tuberculosis, and sexually transmitted diseases ( 54 ).…”

Section: Discussionmentioning

confidence: 99%

Spatial and Temporal Trends in HIV/AIDS Burden Among Worldwide Regions From 1990 to 2019: A Secondary Analysis of the Global Burden of Disease Study 2019

et al. 2022

Front. Med.

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PurposeHIV/AIDS is a critical public health concern worldwide. This article investigated the spatial and temporal trends in HIV/AIDS burden from 1990 to 2019.MethodsData were extracted from the Global Burden of Disease (GBD) Study 2019. The estimated annual percentage change (EAPC) and the age-standardized rate (ASR) were used to quantify the change in trends at the global, regional, and national levels.ResultsIn terms of temporal trends, during the period 1990–2004, increasing trends in prevalence (EAPC = 7.47, 95% confidence interval [CI] 5.84, 9.12), death (EAPC = 10.85, 95% CI 8.90–12.84), and disability-adjusted life years (DALYs) (EAPC = 10.40, 95% CI 8.47–12.36) of HIV/AIDS were observed. During the period 2005–2019, the global trends in HIV/AIDS incidence, death, and DALYs of HIV/AIDS decreased, with the EAPCs of −2.68 (95% CI−2.82–−2.53), −6.73 (95% CI −6.98–−6.47), and −6.75 (95% CI −6.95–−6.54), respectively. However, the disease prevalence showed a slight increasing trend (EAPC = 0.71, 95% CI 0.54–0.87). In terms of spatial trends, over the past 15 years, trends in HIV/AIDS incidence of HIV/AIDS appeared upward in High-middle and High sociodemographic index (SDI) areas (EAPC = 6.51, 95% CI 5.50–7.53; EAPC = 2.31, 95% CI 2.02–2.60, respectively).ConclusionDecreasing trends in HIV/AIDS incidence, death, and DALYs have been observed worldwide over the past 15 years, especially in death and DALYs rates. However, the global population living with HIV/AIDS is still increasing. It is worth noting that an unfavorable trend emerged in High-middle and High SDI areas. Prevention and control of HIV/AIDS still need to be strengthened to counteract these concerning trends.

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“…A parallel review reported 8% prevalence of HBV among PWID living with HIV, pooled from 11 studies [42]. A review focusing on Central Asia and Caucasus found a wide variation in HBV (2.8-79.7%, 10 studies) and HIV (0-30.1%, 26 studies) prevalence among PWID [43].…”

Section: Prevalence Of Sexual Risk and Sexually Transmitted Infectionsmentioning

confidence: 99%

Challenges of sexually transmitted infections and sexual health among people who inject drugs

Dumchev

2021

Current Opinion in Infectious Diseases

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Purpose of reviewThis review provides a summary of recently published research on sexually transmitted infections (STI) and related behaviors among people who inject drugs (PWID), covering three major areas: sexual behavior and its role in STI transmission among PWID, multilevel factors associated with STI risk, and strategies addressing sexual health of PWID. This review is timely given the growing priority of combination prevention approaches and integrated care for PWID. Recent findingsModern research improves the understanding that PWID have an increased risk of STI, which varies by gender, setting, type of substance used, and presence of mental disorders. Major socioeconomic and structural factors, specific and nonspecific to PWID, facilitate inequality and sexual risk behavior. Sexual transmission continues to contribute substantially to the spread of bloodborne infections among PWID, accounting for at least 10% of new HIV cases according to epidemiological modeling. Despite the substantial evidence that behavioral interventions can improve sexual health and reduce sex-related risks among PWID, there is a research-practice gap, reflected in the scarcity of implementation studies published recently.

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Prevalence of HIV, HCV and HBV in Central Asia and the Caucasus: A systematic review

Cited by 34 publications

References 56 publications

Liver Transplantation: A 10-Year Low-Volume Transplant Center Experience in Kazakhstan

Liver Transplantation: A 10-Year Low-Volume Transplant Center Experience in Kazakhstan

Spatial and Temporal Trends in HIV/AIDS Burden Among Worldwide Regions From 1990 to 2019: A Secondary Analysis of the Global Burden of Disease Study 2019

Challenges of sexually transmitted infections and sexual health among people who inject drugs

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