Prevalence of HIV and hepatitis B coinfection in Ghana: a systematic review and meta-analysis

Agyeman, Akosua Adom; Ofori‐Asenso, Richard

doi:10.1186/s12981-016-0107-x

Cited by 51 publications

(60 citation statements)

References 34 publications

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“…Maternal complications due to HBV and HIV co-infection pose significant threat to the survival of both the mother and unborn child. On the other hand, in a low-resourced country such as Nigeria, the economic cost attributable to the impact of HIV and HBV coinfection has been well documented both at the microeconomic (individual) and the macroeconomic (household and population) levels [9]. In addition, a major epidemiologic implication is the increasing probability of dual transmission of new HBV/HIV infections in a mixed setting creating new chimeric recombinant forms (hitherto unknown) which may even pose a greater threat than the two separate epidemics.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of HBV in Pregnant Women, South West Nigeria

Atilola

Tomisin

Randle

et al. 2018

JEGH

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Hepatitis B virus (HBV) remains a leading cause of chronic hepatitis, maternal complications, and neonatal deaths in sub-Saharan Africa. Pregnant women serve as a major reservoir for the persistence and ongoing transmission of hepatitis B virus and HIV in a generalized heterosexual epidemic. The aim of this study is to assess the epidemiology of Hepatitis B infection among pregnant women in South West-Nigeria. This is a cross-sectional study of 353 pregnant women across 10 health facilities in the region. Results showed that of the 353 pregnant women tested, 37 were positive for the HBV antigen giving a prevalence estimate of 10.5% (95% CI: 7.5%-14.2%). We found significant negative association between odds of HBV infection and knowledge of HBV transmission through sex (OR: 0.30: 95%CI-0.11-0.82) and a positive association with blood transfusion in the past three months (OR: 9.5: 95% CI-1.58-57.14). Findings strongly suggest high endemicity of HBV and the possible implication of blood transfusion as a major route of ongoing HBV transmission among pregnant women in southwestern Nigeria. We recommend further study of a prospective design to investigate the possible causal link between blood transfusion and the risk of HBV infection among pregnant women in Nigeria.

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Section: Introductionmentioning

confidence: 99%

Epidemiology of HBV in Pregnant Women, South West Nigeria

Atilola

Tomisin

Randle

et al. 2018

JEGH

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“…A true prevalence of these coinfections is essential for evidence based policy making and resource allocation and planning regarding cost effective interventions especially in a context of limited resources. This will positively impact on general prevention and treatment strategies as in HBV/HIV where ART agents also possess anti HBV activity [16] and the increasing availability of affordable generic Direct acting antivirals (DAA) for HCV treatment. The objectives of this study were to determine the sero-prevalence and correlates of Hepatitis B surface antigen (HBsAg) and anti HCV positivity in HIV/AIDS patients in a regional hospital setting in Cameroon.…”

Section: Introductionmentioning

confidence: 99%

Sero-prevalence and Correlates of Hepatitis B and C Co-infection Among HIV-infected Individuals in Two Regional Hospitals in Cameroon

Luma

Eloumou

Ekaney

et al. 2016

TOAIDJ

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Background:Liver disease related to Hepatitis B (HBV) and C (HCV) infection has become a major cause of morbidity and mortality in HIV/AIDS patients. Data on the prevalence of HBV and HCV in Cameroon remains inconclusive.Objective:We aimed to determine the sero-prevalence and correlates of Hepatitis markers in HIV/AIDS patients in two Regional Hospitals.Methods:A cross-sectional study carried out from December 2014 to March 2015. HIV/AIDS patients aged 21 were included and above, receiving care at HIV treatment centres. Data was collected using a structured questionnaire. Blood samples were collected to screen for Hepatitis with HBsAg and anti HCV antibody rapid immunochromatographic test kits. Correlates of hepatitis were investigated by logistic regression. STATA was used for data analysis.Results:We included 833 HIV/AIDS patients,78.8% (657) were female. Mean age was 44(SD 11) years. Prevalence of Hepatitis in general (total of two viral markers tested) was 8.9% (74/833), with 6.1% for HBsAg and 2.8% for Anti-HCV antibodies. From multivariate analysis, the likelihood of having hepatitis was independently increased by a history of surgical interventions [OR: 1.82(1.06-3.14)], and of sexually transmitted infections [OR: 2.20(1.04-4.67)].Conclusion:Almost one in ten participants with HIV/AIDS attending the BRH and LRH tested positive for either HBsAg or anti HCV antibodies. Screening for HBV and HCV should therefore be integrated to the existing guidelines in Cameroon as it can influence management. More studies are needed to evaluate the extent of liver disease and magnitude of HIV suppression in hepatitis and HIV coinfection in this setting.

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“…5%], those with no history of blood transfusion and those with no history of alcohol intake. Pennap et al [16] in Nigeria, KouassiM'Bengue et al [12] in Cote d'voire and Agyeman and Ofori-Asenso, [17] in Ghana reported same in a similar study.…”

Section: Discussionmentioning

confidence: 54%

Seroprevalence of Hepatitis B and C Viruses among Human Immunodeficiency Virus Infected Patients Accessing Healthcare in Federal Medical Centre, Keffi, Nigeria

Pennap

Oti

Gloria

et al. 2017

JAMB

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Infections of Hepatitis B and C viruses among seropositive Human immunodeficiency virus patients are a growing public health problem in Sub Saharan Africa characterized by unaffordable treatment, severe morbidity and associated mortality. This study was aimed at evaluating the seroprevalence of Hepatitis B and C viruses among HIV infected patients accessing health care at Federal Medical Centre, Keffi, Nigeria. The cross-sectional study took place between May-July 2016. A total of 200 blood samples were collected from HIV patients after informed consent and self-administered questionnaires were completed. The samples were centrifuged and the serum screened for HBV and HCV using the immunochromatographic technique. A general prevalence of infection with hepatitis B and C viruses in the study population was 17.5%. The prevalence of HBV infection was 12.5% while HCV was 5.0%. Females have higher infection rates for both viruses (p > 0.05). HBV infection was highest among those aged 20-29 years (14.3%) and lowest among those aged 30-39 years (6.5%). HCV infection was highest among those aged > 40 years (8.7%)

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Prevalence of HIV and hepatitis B coinfection in Ghana: a systematic review and meta-analysis

Cited by 51 publications

References 34 publications

Epidemiology of HBV in Pregnant Women, South West Nigeria

Epidemiology of HBV in Pregnant Women, South West Nigeria

Sero-prevalence and Correlates of Hepatitis B and C Co-infection Among HIV-infected Individuals in Two Regional Hospitals in Cameroon

Seroprevalence of Hepatitis B and C Viruses among Human Immunodeficiency Virus Infected Patients Accessing Healthcare in Federal Medical Centre, Keffi, Nigeria

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