Prevalence of histopathological intestinal lesions and enteric pathogens in Dutch commercial broilers with time

Veen, C Ter; Bruijn, N. de; Dijkman, Remco; Wit, Janneke

doi:10.1080/03079457.2016.1223271

Cited by 29 publications

(26 citation statements)

References 48 publications

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“…Infectious bronchitis virus and fowl adenovirus have also been implicated [5][6][7][8][9]. It is usually difficult to isolate these enteric viruses in vitro, and many studies with astrovirus, rotavirus and reovirus have reproduced intestinal disease in chickens [8][9][10][11][12][13][14][15][16]; however, the exact etiological agents of RSS remain controversial.…”

Section: Introductionmentioning

confidence: 99%

Viral metagenomic analysis of chickens with runting-stunting syndrome in the Republic of Korea

Kim

Kwon

Jang

et al. 2020

Virol J

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Background and aims: Runting-stunting syndrome (RSS) in chickens, also known as malabsorption syndrome, which is characterized by mild to severe enteritis and diagnosed through typical histopathologic examination as well as clinical signs, results in considerable economic losses. Despite the many studies carried out over decades to determine the etiologic agents of RSS involved in the disease, several outbreaks remained without the elucidation of, potentially multiple, etiologies involved. Methods: We performed comparative analysis of viral metagenomes from four chicken flocks affected with RSS using next-generation sequencing. Primers for the detection of chicken enteric viruses were designed from the sequencing data obtained with metagenomics. Multiplex reverse transcription-polymerase chain reaction (PCR) and PCR were performed to detect a variety of etiological agents previously described in natural cases of RSS.Results: The most abundant viral families identified in this study were Astroviridae, Picornaviridae, Parvoviridae, Caliciviridae, Reoviridae and Picobirnaviridae. Chicken astrovirus sequences were present in all four samples, suggesting an association between chicken astrovirus and RSS and chicken astrovirus as a candidate pathogen responsible for RSS. Picobirnavirus and the newly identified chapparvovirus were found in chickens in the Republic of Korea for the first time, and the genetic diversity of enteric viruses and viral communities was showed. Conclusions: Chicken astrovirus was consistently detected in broilers affected with RSS and the result of this study may contribute to knowledge of enteric diseases and viruses in chickens.

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Section: Introductionmentioning

confidence: 99%

Viral metagenomic analysis of chickens with runting-stunting syndrome in the Republic of Korea

Kim

Kwon

Jang

et al. 2020

Virol J

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“…ORF1a encodes non‐structural proteins, ORF1b encodes RNA‐dependent RNA polymerase, and ORF2 encodes nucleocapsid proteins. Avastrovirus (AAstV) isolated from avian species (Bulbule et al, ; Fu et al, ; Kaithal, Jindal, Kumar, & Mor, ; Mándoki, Dobos‐Kovács, Bakonyi, & Rusvai, ; Ter Veen, de Bruijn, Dijkman, & de Wit, ) is one of the leading causes of diseases in birds such as nephritis in chickens, hepatitis and stunting in ducks and gout in goslings (Bidin, Lojkic, Tisljar, Bidin, & Majnaric, ; Liu et al, ; Jin et al, ; Liu, Jiang, Dong, Wang, & Zhang, ; Yang, Tian, Tang, & Diao, ; Zhang, Cao, et al, ; Zhang, Wang, Liu, Yang, & Zhang, ).…”

Section: Introductionmentioning

confidence: 99%

Characterization and genomic analysis of emerging astroviruses causing fatal gout in goslings

Chen

et al. 2019

Transbound Emerg Dis

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Since February 2017, severe outbreaks of fatal gout caused by novel gosling astroviruses (GoAstVs) have occurred in several Chinese provinces, causing a considerable economic impact on the poultry industry. To assess the infection status of GoAstVs causing gout, 165 clinical samples were collected from goslings from seven farms located in different Chinese provinces, and they were screened for viral infection. Seven GoAstV strains were completely sequenced. The positive infection rates of GoAstV, goose parvovirus, reovirus, goose haemorrhagic polyomavirus and Tembusu virus were 100%, 9.69%, 3.64%, 0% and 0%, respectively, indicating the role of GoAstV in gout. The genomes of all seven GoAstV strains were 7170‐nt long and encoded three open reading frames (ORFs), namely, ORF1a, ORF1b and ORF2. Sequence and phylogenetic analyses of the seven GoAstV strains showed that these were avastroviruses and were closely related to viruses classified within Avastrovirus 3 and turkey astrovirus 2. Moreover, the mutation rates of ORF1a and ORF2 were high, and ORF1a was highly mutated at amino acid loci 545–580. The tertiary structure of the mutated ORF2 protein was smooth, and its antigenic epitope was highly mutated, which may be related to the pathogenicity of the virus and caused by antibody pressure from the host. These findings enrich our understanding of the evolution of novel GoAstVs causing gout and their circulation as well as lay the foundation for the selection of vaccine strains.

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“…In poultry farming, intestinal diseases have a major impact on technical performance and animal welfare. Decreased digestion efficacy and nutrients absorption exaggerated by an increased and changed need for energy and nutrients will lead to growth depression and increased feed conversion ratio (ter Veen, de Bruijn, Dijkman, & de Wit, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…A number of well-defined enteric pathogens and their pathology have been described. Of these Eimeria acervulina, E. maxima , E. tenella and necrotic enteritis are most important in broilers farming (ter Veen et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…The broiler industry relies on in-feed prophylaxis with application of anticoccidial drugs (Haug, Gjevre, Thebo, Mattsson, & Kaldhusdal, 2008), but this clashes with the public's concern regarding the use of drugs in intensive farming. Use of antimicrobials and anticoccidial drugs in animals poses a potential risk for public health since it contributes to the selection and spread of resistant microbes in the environment (Speksnijder, Mevius, Bruschke, & Wagenaar, 2015) Antimicrobials resistance is the global health issue integrating human, animal, and environmental health that makes public bodies as UN or the WHO setting a global agenda to contrast the crisis (Laxminarayan, Sridhar, Blaser, Wang, & Woolhouse, 2016). Even if substantial funds have been committed in the United States and Europe to tackle antimicrobials resistance, there is the need to incentivize the development of new vaccines, diagnostics, novel therapies, and stewardship methods (Laxminarayan et al, 2016).The clearest consequence of antibiotic release in natural environments is the selection of resistant bacteria (Martinez, 2009), causing antibiotic-resistant infections that add considerable costs to health care systems.…”

Section: Introductionmentioning

confidence: 99%

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Application of an early warning to detect enteropathies in intensive broiler farming

Tullo¹,

Borgonovo²,

Grilli³

et al. 2018

10th International Livestock Environment Symposium (ILES X)

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Remote and wearable sensors can be combined with smart algorithms to continuously monitor a wide range of animal responses linked with stress, health status and welfare. The idea of real time monitoring assumes a simple way to measure variable that can give an early warning for the farmer providing clear and suitable alerts to help them in their routine. The prompt reaction to any change in health, welfare and productive status is the key for the reduction in drugs usage and for the improvement of animal wellbeing. In intensive poultry farms, enteric disorders represent a major health issue; these pathologies could be multifactorial and are a major cause of performances reduction. Monitoring poultry health status takes a key role for management to reduce chemicals/drugs and their costs. Nowadays, the preventive use of antibiotics in intensive farming system is common and this practice could lead to the spreading of drugs in the environment, contributing to the phenomenon of antibiotic resistance. Due to the high priority of this issue, it is of great importance the early detection of any health problem in intensive farming. Precision Livestock Farming, through the combination of cheap technologies and specific algorithms, can provide valuable information for farmers starting from the huge amount of data collected in real time at farm level. This study was aimed to the application of a PLF diagnostic tool, sensible to the variation of volatile organic compounds, to promptly recognize enteric problems in intensive farming, supporting veterinarians and enabling specific treatments in case of disease.

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Prevalence of histopathological intestinal lesions and enteric pathogens in Dutch commercial broilers with time

Cited by 29 publications

References 48 publications

Viral metagenomic analysis of chickens with runting-stunting syndrome in the Republic of Korea

Viral metagenomic analysis of chickens with runting-stunting syndrome in the Republic of Korea

Characterization and genomic analysis of emerging astroviruses causing fatal gout in goslings

Application of an early warning to detect enteropathies in intensive broiler farming

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