Prevalence of high-risk human papillomaviruses and abnormal PAP smears among women visiting gynaecological outpatient units in Kazakhstan: A cross sectional study.

Kaidarova, Dilyara; Kairbayev, Murat; Hong, Kim Jae; Han, Byoung-Don; Sanzhar, Ismailov; Shibanova, A I; Kukubassov, Yerlan; Shalbayeva, Rash; Yeleubayeva, Zhanar; Bolatbekova, Raikhan; Park, Han Jeong; Kim, Hye Jeong

doi:10.1200/jco.2018.36.15_suppl.e13596

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“…Our cytologic abnormality detection rate was 4.16%, which is consistent with our previous reports [8,9]. Consistent with previous studies [18][19][20], ASCUS was the most common cytologic abnormality among HR-HPV positive women, and colposcopy was performed for further investigation.…”

Section: Discussionsupporting

confidence: 92%

Prevalence of High-Risk HPV Detection and HPV Vaccination in Cervical Cancer Screening During the HPV Vaccination Era at Siriraj Hospital – Thailand’s Largest National Tertiary Referral Center

Chaopotong,

Laiwejpithya,

Areeswate

2024

Asian Pac J Cancer Prev

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Objective: To investigate the prevalence of high-risk (HR) human papillomavirus (HPV) detection and HPV vaccination among women undergoing cervical cancer screening during the HPV vaccination era at Siriraj Hospital – Thailand’s largest national tertiary referral center. Methods: This prospective cross-sectional study was conducted at our center’s outpatient gynecology clinic during September-December 2021. Women aged ≥18 years with no previous hysterectomy, no history of preinvasive or invasive cervical cancer, and no current pregnancy who visited for cervical cancer screening were eligible for enrollment. Women with abnormal vaginal discharge/bleeding, and specimens with inadequate cellularity were excluded. We collected sociodemographic data, history of HPV vaccination, cervical cytology results, and high-risk HPV testing results. Reverse transcription polymerase chain reaction was used to determine HPV genotype. Results: A total of 216 women (mean age: 41.7 years (range: 25-65), 75.9% premenopausal) were enrolled. Twenty of 216 (9.3%) women tested positive for HR-HPV, and 15 of 216 (6.9%) women had been previously vaccinated for HPV. The most common HPV genotypes detected were Group B infection (HPV 35/39/51/56/59/66/68) (38.9%), followed by HPV16 (27.78%), Group A infection (HPV 31/33/52/58) (27.8%), and HPV18 (5.56%). No HPV45 infection was detected. The detection rate of cytologic abnormalities was 4.16%. Three-quarters (77.8%) of patients with cytologic abnormalities were HR-HPV positive. Conclusion: Among the 216 women who underwent cervical cancer screening in this study, there was a 9.3% prevalence of HR-HPV infection, and a 6.9% prevalence of HPV vaccination. Among the 15 vaccinated women, 2 tested positive for HPV16 (1 normal cytology, 1 abnormal cytology).

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Section: Discussionsupporting

confidence: 92%