Prevalence of high‐risk human papillomavirus type 16 and 18 in oral and cervical cancers in population from <scp>G</scp>ujarat, <scp>W</scp>est <scp>I</scp>ndia

Patel, Kinjal D.; Vajaria, Bhairavi N.; Begum, Rasheedunnisa; Desai, Ajesh; Patel, J. D.; Shah, Franky D.; Shukla, Shilin N.; Patel, Prabhudas S

doi:10.1111/jop.12147

Cited by 34 publications

(39 citation statements)

References 33 publications

(50 reference statements)

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“…15 Our results are in agreement with two studies conducted in Gujarat and Mumbai in West India, which reported a null prevalence of HPV in oral cancer using biopsies (in one of the studies, only HPV-16 and 18 were tested). 27,28 However, considering the fact that only two previous studies showed a null prevalence in oral cancer in India, we explored other explanations for these results.…”

Section: Discussionmentioning

confidence: 99%

“…The reported HPV prevalence in oral cancers in India varied from 0 to 100% in studies using biopsies in cases and PCR assay for HPV detection and genotyping. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] For the studies using a methodology similar to ours (oral brushing to collect epithelial cells instead of biopsy, combined with PCR for detection and genotyping), the prevalence reported for oral cancer cases was 31.5 26 and 32.4%. 15 Our results are in agreement with two studies conducted in Gujarat and Mumbai in West India, which reported a null prevalence of HPV in oral cancer using biopsies (in one of the studies, only HPV-16 and 18 were tested).…”

Section: Discussionmentioning

confidence: 99%

“…12 One-on-one semistructured interviews using a questionnaire and life grid technique, which has been shown to improve recall, 13 were conducted by three professionally trained dentists. Data collected included sociodemographic information, religious beliefs, environmental variables and sexual behavior including age at first sexual intercourse, number of sexual partners and oral sex practice frequency during three different life stages ( 16,(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) and >30 years).…”

Section: Patient and Data Collectionmentioning

confidence: 99%

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No role for human papillomavirus infection in oral cancers in a region in southern India

Laprise

Madathil

Allison

et al. 2015

Intl Journal of Cancer

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Oral cancer is a major public health issue in India with~77,000 new cases and 52,000 deaths yearly. Paan chewing, tobacco and alcohol use are strong risk factors for this cancer in India. Human papillomaviruses (HPVs) are also related to a subset of head and neck cancers (HNCs). We examined the association between oral HPV and oral cancer in a sample of Indian subjects participating in a hospital-based case-control study. We recruited incident oral cancer cases (N 5 350) and controls frequencymatched by age and sex (N 5 371) from two main referral hospitals in Kerala, South India. Sociodemographic and behavioral data were collected by interviews. Epithelial cells were sampled using Oral CDx V R brushes from the oral cancer site and the normal mucosa. Detection and genotyping of 36 HPV genotypes were done using a polymerase chain reaction protocol. Data collection procedures were performed by qualified dentists via a detailed protocol with strict quality control, including independent HPV testing in India and Canada. HPV DNA was detected in none of the cases or controls. Associations between oral cancer and risk factors usually associated with HPV infection, such as oral sex and number of lifetime sexual partners, were examined by logistic regression and were not associated with oral cancer. Lack of a role for HPV infection in this study may reflect cultural or religious characteristics specific to this region in India that are not conducive to oral HPV transmission. A nationwide representative prevalence study is needed to investigate HPV prevalence variability among Indian regions.Worldwide, nearly 300,000 new cases of oral cancers are diagnosed each year, accounting for 145,000 deaths. Approximately 77,000 new cases and 52,000 oral cancer-related deaths occur yearly in India, representing a quarter of all incident cases in the world. 1 Known risk factors include tobacco smoking and chewing, high alcohol consumption and, in a country such as India, paan chewing. 2 Oral human papillomavirus (HPV) infection has recently been recognized as another important risk factor for head and neck cancer (HNC), mainly for the oropharyngeal cancer subsite. In fact,

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Patient and Data Collectionmentioning

confidence: 99%

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No role for human papillomavirus infection in oral cancers in a region in southern India

Laprise

Madathil

Allison

et al. 2015

Intl Journal of Cancer

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“…However, the contribution of HR‐HPV to HNC appears to be the subject to geographical variability . Although HNC incidence is very high in India, only a limited number of studies have evaluated the contribution of HPV infection . In these studies, the proportion of HPV‐positive cases was established only by detecting viral DNA using PCR‐based assays, and HPV positivity of HNC cases substantially varied between studies, ranging from 15% to 70% .…”

Section: Discussionmentioning

confidence: 99%

“…The habit of chewing betel quid often mixed with tobacco is widespread in South Asia, and also plays a key role in HNC development . Although age‐standardized rates of cervical cancer are among the highest in India (22.0/100,000), highlighting the importance of HPV infections in this population, limited information on HPV‐associated HNC exists . The studies published thus far have been based on a limited number of cases.…”

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confidence: 99%

Role of mucosal high‐risk human papillomavirus types in head and neck cancers in central India

Gheit

Anantharaman

Holzinger

et al. 2017

Intl Journal of Cancer

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Mucosal high-risk (HR) human papillomaviruses (HPV) cause a subset of head and neck cancers (HNC). The HPV-attributable fraction of HNC varies substantially between countries. Although HNC has a very high incidence in the Indian subcontinent, information on the contribution of HPV infection is limited. Here, we evaluated the HPV-attributable fraction in HNC (N = 364) collected in a central region of India. HNC from three different anatomical subsites were included, namely, oral cavity (n = 252), oropharynx (n = 53) and hypopharynx/larynx (n = 59). In this retrospective study, HPV-driven HNC were defined by presence of both viral DNA and RNA. Overexpression of p16 was also evaluated. HR-HPV DNA was detected in 13.7% of the cases; however, only 2.7% were positive for both HPV DNA and RNA. The highest percentage of HPV DNA/RNA double positivity was found in oropharynx (9.4%), followed by larynx (1.7%) and oral cavity (1.6%) (p = 0.02). More than half of HPV DNA/RNA-positive cases were p16 -negative, while a considerable number of HPV RNA-negative cases were p16 -positive (17.9%). HPV16 was the major type associated with HNC (60.0%), although cases positive for HPV18, 35 and 56 were also detected. Our data indicate that the proportion and types of mucosal HR-HPV associated with HNC in this central Indian region differ from those in other (developed) parts of the world. This may be explained by differences in smoking and/or sexual behaviour compared with North America and northern Europe. Moreover, we show that p16 staining appeared not to be a good surrogate marker of HPV transformation in the Indian HNC cases.

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HPV-avertable cancer risks in India: A pooled analysis of 9 observational studies

et al. 2014

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Dear Sir, We read with great interest the article by Michaud et al. 1 "Highrisk HPV types and head and neck cancer." Their research presents the associations between infections with high-risk HPV subtypes and head and neck cancer risk in the US. In addition to HPV16, HPV18/33, and HPV52 emerged as important risk factors for oropharyngeal and oral cancers, respectively.Oral cancer is the most common form of malignant cancers in the Indian subcontinent; it accounts for one-third of the global burden of oral cancer incidence and mortality. 2,3 Despite extensive improvements in diagnosis and therapy in recent decades, the prognosis of oral cancers remains poorly understood. 4 In the Indian sub-populations, oral cancer is primarily associated with commonly known risk factors such as tobacco chewing and bidi or cigarette smoking. However, additional risk factors may be at play, as suggested by the incidence of oral cancer in approximately 20% of the patients, who develop this malignancy without a definite etiology of risk factors. 5 Similarly, cervical cancer in India constitutes a quarter of the global burden with 132,000 new cases and 74,000 deaths every year. 3 It is the leading malignancy in our region with age standardized rates of 14.3 and 7.7 per 100,000 individuals from urban and rural areas, respectively. 6 Mixed claims have been made regarding the association of HPV infection with the development of both cervical and oral cancers in different regions of India. 7,8 In addition, limited information is available on the distribution of HPV types in the country. This makes it important to further explore the association between HPV types, and cervical and oral cancers.Based on the existing literature from the Indian context, we conducted a meta-analysis on the association of HPV and high-risk HPV types on head and neck, and cervical cancer Figure 1. Meta-analysis of the association between HPV subtypes and cervical and head and neck cancers in India.

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Prevalence of high‐risk human papillomavirus type 16 and 18 in oral and cervical cancers in population from Gujarat, West India

Cited by 34 publications

References 33 publications

No role for human papillomavirus infection in oral cancers in a region in southern India

No role for human papillomavirus infection in oral cancers in a region in southern India

Role of mucosal high‐risk human papillomavirus types in head and neck cancers in central India

HPV-avertable cancer risks in India: A pooled analysis of 9 observational studies

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