Prevalence of high-risk human papilloma virus genotypes and associated risk of cervical precancerous lesions in a large U.S. screening population: Data from the ATHENA trial

Monsonégo, Joseph; Cox, J. Thomas; Behrens, Catherine M.; Sandri, Maria Teresa; Franco, Eduardo L.; Yap, Poh Sin; Huh, Warner K.

doi:10.1016/j.ygyno.2015.01.551

Cited by 137 publications

(170 citation statements)

References 27 publications

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“…The results of the present study for the frequency of HPV types 16 and 18 are consistent with previous reports from other regions in Iran and worldwide, which indicate a high proportion of these HPV genotypes in the general population compared to other high-risk HPV types (18)(19)(20)(21). However, compared to studies applying cytological or DNA-based methods for identification of HPVs among healthy women, the rates of HPV types 16 and 18 in the present study were relatively high.…”

Section: Discussionsupporting

confidence: 90%

Seroepidemiological Evaluation of High-Risk Human Papillomavirus Types Among Married and Unmarried Iranian Women in Tehran, Iran

Abedini

Karimi

Shamsy

et al. 2016

Arch Pediatr Infect Dis

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Background: Human papillomavirus (HPV) is a DNA virus that establishes productive infections only in keratinocytes of the skin or mucous membranes. Objectives: This study aimed to determine the frequency of two high-risk genotypes of HPV among married and unmarried Iranian women. Materials and Methods:This cross-sectional population-based study consisted of two groups of women: non-married girls referred for premarital counseling, and married women referred for pregnancy diagnosis. Blood samples were evaluated serologically with the ELISA method for HPV types 16 and 18. Results: A total of 177 women (89 single and 88 married) were tested for HPV strains. The frequency of HPV type 16 in single women was significantly higher than in married women (66.3% vs. 40.9%, P < 0.001). The relative frequency of HPV type 18 was also significantly higher in single women than in married women (62.9% vs. 47.7%, P < 0.001). Moreover, HPV type 16 and 18 positivity was significantly associated with higher education levels in single women compared to married women (P < 0.001). Classification of HPV-infected women according to age revealed that the frequency of HPV type 16 was significantly higher in single women aged 25 -35 years compared to married women (P < 0.05). Conclusions:The results showed remarkable rates of high-risk HPV types (16 and 18) in the studied population, which can be a serious alert for public health. This result highlights the potential impact of prophylactic vaccines for future protection against high-risk HPV types in Iranian women.

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Section: Discussionsupporting

confidence: 90%

Seroepidemiological Evaluation of High-Risk Human Papillomavirus Types Among Married and Unmarried Iranian Women in Tehran, Iran

Abedini

Karimi

Shamsy

et al. 2016

Arch Pediatr Infect Dis

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“…This discrepancy, already observed in many studies having high‐grade CIN as the endpoint,6, 10, 33, 34 could result from a different natural history of cell transformation induced by HPV18 and 45. In fact, these genotypes are over‐represented in adenocarcinomas and early onset cancers35, 36, 37 and are rarely prevented through cytological screening 2, 38, 39.…”

Section: Discussionmentioning

confidence: 92%

Human papilloma virus genotyping for the cross‐sectional and longitudinal probability of developing cervical intraepithelial neoplasia grade 2 or more

Mistro

Adcock

Carozzi

et al. 2018

Intl Journal of Cancer

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Human papilloma virus (HPV) testing is more sensitive but less specific than cytology. We evaluated stand‐alone genotyping as a possible triage method. During a multicentre randomised controlled trial comparing HPV testing to conventional cytology, HPV‐positive women were referred to colposcopy and followed up if no high‐grade lesion was detected. HPV‐positive samples were genotyped by GP5+/GP6+ primed polymerase chain reaction followed by reverse line blot. Genotypes were hierarchically ordered by positive predictive value (PPV) for CIN grade 2 or more (CIN2+), and grouped by cluster analysis into three groups (A, B and C in decreasing order). Receiver operating characteristic curves were computed. Among 2,255 HPV‐positive women with genotyping, 239 CIN2+ (including 113 CIN3+) were detected at baseline or during a 3‐year follow‐up. HPV33 had the highest PPV with CIN2+ and CIN3+ as the endpoint and when considering lesions detected at baseline or also during follow‐up. HPV16 and HPV35 were the second and third, respectively. Cross‐sectional sensitivity for CIN2+ at baseline was 67.3% (95% CI 59.7–74.2), 91.8% (95% CI 86.6–95.5) and 94.7% (95% CI 90.2–97.6), respectively, when considering as “positive” any of the HPV types in group A (33, 16 and 35), A or B (31, 52, 18, 59 and 58) and A or B or C (39, 51, 56, 45 and 68). The corresponding cross‐sectional PPVs for CIN2+ were 15.8% 95% (CI 13.2–18.7), 12.0% (95% CI 10.3–13.9) and 9.6% (95% CI 8.2–11.1), respectively. HPV33, 16 and 35 confer a high probability of CIN2+ but this rapidly decreases when adding other genotypes.

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“…These studies report an improvement in detection of CIN2+ with increased by biopsy collection can be increased by as much as 37%. 18,[37][38][39] The involvement of colposcopists in the systematic collection of biopsies will be an important step to ensure the detection of CIN2 + cases that require prompt treatment. The FRIDA Study will also document the benefit of adopting a systematic collection of cervical biopsies as routine colposcopy practice.…”

Section: Resultsmentioning

confidence: 99%

Triage strategies in cervical cancer detection in Mexico: methods of the FRIDA Study

et al. 2016

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Objective. This paper describes the study design and baseline characteristics of the study population, including the first 30 829 women who enrolled in the Forwarding Research for Improved Detection and Access for Cervical Cancer Screening and Triage (FRIDA Study). This is a large population based study that is evaluating the performance and cost-effectiveness of different triage strategies for high-risk HPV (hrHPV) positive women in Mexico. Materials and methods. The target population is more than 100 000 women aged 30 to 64 years who attend the Cervical Cancer Screening Program in 100 health centers in the state of Tlaxcala, Mexico. Since August 2013, all women in the region have been invited to ResumenObjetivo.

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Prevalence of high-risk human papilloma virus genotypes and associated risk of cervical precancerous lesions in a large U.S. screening population: Data from the ATHENA trial

Cited by 137 publications

References 27 publications

Seroepidemiological Evaluation of High-Risk Human Papillomavirus Types Among Married and Unmarried Iranian Women in Tehran, Iran

Seroepidemiological Evaluation of High-Risk Human Papillomavirus Types Among Married and Unmarried Iranian Women in Tehran, Iran

Human papilloma virus genotyping for the cross‐sectional and longitudinal probability of developing cervical intraepithelial neoplasia grade 2 or more

Triage strategies in cervical cancer detection in Mexico: methods of the FRIDA Study

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