Prevalence of High Risk HPV in HIV-Infected Women From Belém, Pará, Amazon Region of Brazil: A Cross-Sectional Study

Monteiro, Jacqueline Cortinhas; Fonseca, Ricardo Roberto de Souza; Silva, Andreza Reis Brasil da; Gomes, Samara Tatielle Monteiro; Silvestre, Rodrigo Vellasco Duarte; Silva, Andrea Nazaré Monteiro Rangel; Pamplona, Ilze; Vallinoto, Antônio Carlos Rosário; Ishak, Ricardo; Machado, Luiz Fernando Almeida

doi:10.3389/fpubh.2021.649152

Cited by 13 publications

(15 citation statements)

References 42 publications

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“…Moodley et al observed a risk about 5 times higher among women living with HIV of presenting with a high oncogenic risk Human Papillomavirus infection when compared to HIV-negative women (21) . This association was also observed by Monteiro et al, who showed that coinfection was present in 63% of the sample (37) . A previous study also carried out in Florianópolis showed higher prevalence of HPV infection among HIV-positive women (70%), in comparison to HIV-negative women (21%) (19) .…”

Section: Discussionsupporting

confidence: 84%

Prevalence of HPV infection and cervical intraepithelial lesions in HIV positive and negative women in the city of Florianopolis

Conradesque

Dagostin

Fedrizzi

et al. 2023

J Bras Doenças Sex Transm

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Introduction: The human papillomavirus (HPV) is the most common sexually transmitted infection among women. The HPV of high oncogenic risk, associated with other factors, presents a risk of progressing to a precancerous lesion of the uterus and even cancer. Such an evolution is related to the persistence of the infection and other factors, mainly those that interfere with women’s immunity. The immunosuppression caused by HIV infection is an important factor for viral persistence and the onset of these lesions. Objectives: To compare the prevalence of HPV infection and cervical intraepithelial lesions in HIV-positive and negative women and describe the possible associated risk factors. Methods: The sample consisted of 50 HIV positive women (study group) and 50 HIV negative women (control group) recruited from the public health system of Florianópolis from January to April 2022. Cervical samples were collected for cytological analysis and for the detection of high-risk oncogenic HPV DNA by polymerase chain reaction (PCR). Categorical variables were compared using the chi-square test, with a significance level set at 5% Results: HPV infection was more prevalent in the control group; however, HIV positive women presented higher frequency of intraepithelial lesions diagnosed on cytology. Factors such as higher number of sexual partners, depression and smoking were more frequent in the group of HIV positive women. CD4 T cells lower than 200 cells/mm3 was associated with a higher number of altered Pap smears and a positive HPV DNA test. The use of combination antiretroviral therapy and undetectable viral load were associated with more frequent normal cytology and undetected HPV DNA. Conclusion: The prevalence of cervical intraepithelial lesions in HIV-infected women is higher than among women without the infection. The presence of HIV infection was the most important risk factor associated with the development of cervical lesions.

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Section: Discussionsupporting

confidence: 84%

Prevalence of HPV infection and cervical intraepithelial lesions in HIV positive and negative women in the city of Florianopolis

Conradesque

Dagostin

Fedrizzi

et al. 2023

J Bras Doenças Sex Transm

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“…In this study, risk factors such as smoking (70.3%) and alcohol overconsumption (70.3%) proved to be an important etiology factor to OSCC, confirming the results of all the studies mentioned above, although among our samples, the smoking and alcohol overconsumption associated with HR HPV prevalence could not be inferred, which was similar to the other studies prior. Perhaps the influence and the prevalence of HR HPV over OL might be impacted by other risk factors besides smoking and alcohol overconsumption, such as unsafe sex, multiple sexual partners, drug dependence, lack of access to public health services, co-infections such as HIV-HPV, and HPV non-vaccination, which would facilitate HPV throughout the state [ 1 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…The human papillomavirus (HPV) is a member of the Papillomaviridae family. According to Monteiro et al [ 1 ], there are more than 130 species and nearly 228 HPV genotypes have been identified so far—all with the capacity to tropism for mucosal and cutaneous epithelia, such as squamous tissue. As explained by the International Committee on Taxonomy of Viruses (ICTV), HPV is a small non-enveloped double-stranded circular DNA virus approximately 52–55 nm of diameter, which is composed by a protein icosahedral capsid made of 72 pentameric capsomeres that surround the viral genome with 8000 nucleotide base pairs [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Genotyping of HPV in Oral Squamous Cell Carcinoma in Northern Brazil

et al. 2022

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Highly oncogenic human papillomavirus (HPV) is well known to be associated with and a risk factor for various types of oral carcinomas such as oral squamous cell carcinoma (OSCC). The aim of this study was to evaluate and describe the HPV-induced OSCC prevalence and genotyping in the city of Belém, northern Brazil. This cross-sectional study features 101 participants who attended an oral pathology referral center in a dental college looking for diagnoses of oral lesions (OL). After signing the consent term and meeting the inclusion criteria, all participants went through a sociodemographic and epidemiological questionnaire. Then, OL were collected by excisional or incisional biopsy depending on OL size; after that, OL tissues were preserved in paraffin blocks to histopathological diagnoses. Afterwards, paraffin blocks were divided into benign and malignant/premalignant lesions based on the classification of potentially malignant disorders of the oral and oropharyngeal mucosa. Then, the paraffin blocks had DNA extraction performed by the ReliaPrep FFPE gDNA Miniprep method in order to identify HPV DNA of high oncogenic risk and low oncogenic risk. Then, the viral DNA was amplified and typed using the Inno-Lipa genotyping Extra II method, and the collected data were analyzed by Chi-square and G-tests. In total, 59/101 (58.4%) OL were malignant/premalignant lesions, of which OSCC was the most prevalent with 40/59 (67.7%) and 42/101 (41.6%) benign lesions. The most common area of OL incidence was upper gingiva 46/101 (45.5%). Regarding HPV DNA detection, approximately 27/101 (26.7%) had positive results; of these, 17/59 (28.8%) were malignant/premalignant lesions, and the most prevalent genotypes detected were 16, 18, 52 and 58, while among benign lesions, 10/42 (66.6%) had HPV-positive results, and the most prevalent genotypes detected were 6, 11 and 42. Age range was the only risk factor with a significant association between HPV and OSCC presence (p-value: 0.0004). A correlation between OSCC and oral HPV among analyzed samples could not be demonstrated in our small cohort.

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“…It consists of double-stranded non-enveloped DNA viruses. So far, about 228 different HPV genotypes have been found [7] and categorized as low-or high-risk based on their oncogenic potential [8,9]. Genital warts may be caused by low-risk (LR) HPV genotypes, while high-risk (HR) types can cause malignant transformation of cells in the cervix, vagina, vulva, penis, anus, and mouth [10].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Human Papillomavirus in Iranian infertile men and its association with semen quality

Niakan

Faghihloo

Mofarahe

et al. 2023

Preprint

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Background: The present article aims to elucidate the prevalence of Human Papillomavirus (HPV) infection and possible association between HPV infection and semen parameters in infertile Iranian men. Materials and methods: This cross-sectional study included semen samples from 140 male partners in couples seeking fertility evaluation. Standard semen analysis was performed. In addition, sperm DNA fragmentation index (DFI), sperm chromatin maturation, presence of anti-sperm antibodies, leukocyte count, and Fructose and Zinc concentration were also assessed. Nested PCR and INNO-LiPA assay were used to identify HPV-DNA sequences in semen samples and determine HPV genotype, respectively. Results: HPV DNA was detected in 18/140 (12.85%) of the semen samples (10% high-risk (HR), 2.14% low-risk (LR) genotypes, and one sample was excluded). Our findings revealed that HPV18 was the most prevalent type (8.57%). According to our result, the presence of HPV DNA in the semen samples was associated with a higher white blood cell count (leukocytospermia) (P=0.02). We also observed that LR HPV-positive semen samples were associated with higher DFI values (P = 0.01). Conclusion: This study showed that the presence of HPV in semen samples was associated with leukocytospermia. We also observed that the presence of low-risk genotypes in semen samples was associated with higher sperm DFI values. These results point to the importance of careful screening for the presence of HPV in semen samples from infertile men. It should also be noted that more studies are required to have a more comprehensive view of the relationship between HPV infection and semen quality.

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Prevalence of High Risk HPV in HIV-Infected Women From Belém, Pará, Amazon Region of Brazil: A Cross-Sectional Study

Cited by 13 publications

References 42 publications

Prevalence of HPV infection and cervical intraepithelial lesions in HIV positive and negative women in the city of Florianopolis

Prevalence of HPV infection and cervical intraepithelial lesions in HIV positive and negative women in the city of Florianopolis

Prevalence and Genotyping of HPV in Oral Squamous Cell Carcinoma in Northern Brazil

Prevalence of Human Papillomavirus in Iranian infertile men and its association with semen quality

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