Prevalence of high fractional exhaled nitric oxide among US youth with asthma

Nguyễn, Dương T; Kit, Brian K.; Brody, Debra J.; Akinbami, Lara J.

doi:10.1002/ppul.23672

Cited by 10 publications

(9 citation statements)

References 33 publications

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“…Further studies are needed to determine whether this was simply due to the increase of Hb synthesis caused by hypoxia or related to other factors, such as expression changes of haptoglobin (related to Hb catabolism), which plays an important role in immune regulation and the pulmonary inflammatory response (30). The age, disease course and FeNO levels in the pulmonary function abnormality group were greater than those in the pulmonary function restored group, which is consistent with previous reports (31,32). Kanemitsu et al (33) reported that periostin was an independent risk factor for FEV1 decline.…”

Section: Discussionsupporting

confidence: 86%

Establishing a patient registry study database of dust mite allergic asthma in children: design, methodology and preliminary exploration

Zhou¹,

Li²,

Wen³

et al. 2021

Ann Transl Med

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Background: Asthma is a heterogeneous disease with different phenotypes, endotypes and responses to treatment. Dust mite allergic asthma (DMAA) is the most common type in children. Compared with randomized control trials, a patient registry study (PRS) can reflect the real physical condition and clinical diagnosis more comprehensively.Methods: Children who visited the asthma clinic of the Children's Hospital of Chongqing Medical University between August 2018 and August 2020, and met the inclusion criteria and also agreed to participate, were enrolled in the registry study. Clinical information, laboratory tests and peripheral blood samples were collected after informed consent was given by guardians.Results: To date, 208 children have been enrolled in the patient registry database of DMAA. They are mainly male, with >50% having a history of allergic rhinitis, cesarean section, positive family history and passive smoking. Eosinophils and total immunoglobulin E levels were all significantly higher than normal. According to results for the childhood asthma control test (c-ACT) and ratio of forced expiratory volume in 1 s to predicted value after inhaled corticosteroid treatment, the uncontrolled group had higher hemoglobin (Hb) levels than the control group. The group exhibiting abnormal pulmonary function was older, and had longer disease duration, higher fractional exhaled nitric oxide and Hb than the group in which pulmonary function was restored. Conclusions:We have preliminarily established a registered study database of children with DMAA. By cluster analysis and using blood samples, we can further study the different pathophysiological mechanisms in order to provide more individualized and targeted treatments for all children.

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Section: Discussionsupporting

confidence: 86%

Establishing a patient registry study database of dust mite allergic asthma in children: design, methodology and preliminary exploration

Zhou¹,

Li²,

Wen³

et al. 2021

Ann Transl Med

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“…Currently, it is known that F E NO values are influenced by age, 5 gender, 5,6 height, 5 atopy, 5,6 smoking, 5,7 respiratory infections, 5 environmental factors, 8 physical activity, 9 and ethnicity. 10 Females have consistently been reported to have lower F E NO levels than men with about 25% lower levels. 5,6 Some of the explanation might reside in differences in height, another known determinant of F E NO, but other differences appear to be exist with regard to gender.…”

Section: Introductionmentioning

confidence: 99%

“…For F E NO to be reliable as a biomarker, it is important to know factors that influence F E NO values. Currently, it is known that F E NO values are influenced by age, gender, height, atopy, smoking, respiratory infections, environmental factors, physical activity, and ethnicity . Females have consistently been reported to have lower F E NO levels than men with about 25% lower levels .…”

Section: Introductionmentioning

confidence: 99%

Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III

Nerpin

Olivieri

Gislason

et al. 2019

Clin Experimental Allergy

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Introduction The fractional exhaled nitric oxide (FENO) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors that influence FENO in healthy individuals. Men have higher levels of FENO than women, but it is unclear whether determinants of FENO differ by sex. Objective To identify determinants of FENO in men and women without lung diseases. Method Fractional exhaled nitric oxide was validly measured in 3881 healthy subjects that had answered the main questionnaire of the European Community Respiratory Health Survey III without airways or lung disease. Results Exhaled NO levels were 21.3% higher in men compared with women P < 0.001. Being in the upper age quartile (60.3‐67.6 years), men had 19.2 ppb (95% CI: 18.3, 20.2) higher FENO than subjects in the lowest age quartile (39.7‐48.3 years) P = 0.02. Women in the two highest age quartiles (54.6‐60.2 and 60.3‐67.6 years) had 15.4 ppb (14.7, 16.2), P = 0.03 and 16.4 ppb (15.6, 17.1), P = <0.001 higher FENO, compared with the lowest age quartile. Height was related to 8% higher FENO level in men (P < 0.001) and 5% higher FENO levels in women (P = 0.008). Men who smoked had 37% lower FENO levels and women had 30% lower levels compared with never‐smokers (P < 0.001 for both). Men and women sensitized to both grass and perennial allergens had higher FENO levels compared with non‐sensitized subjects 26% and 29%, P < 0.001 for both. Conclusion and Clinical Relevance Fractional exhaled nitric oxide levels were higher in men than women. Similar effects of current smoking, height, and IgE sensitization were found in both sexes. FENO started increasing at lower age in women than in men, suggesting that interpretation of FENO levels in adults aged over 50 years should take into account age and sex.

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“…For example, one study in Vietnam found that FeNO in healthy people was not associated with epidemiological factors of the participants such as age, gender, weight, BMI except a fair correlation with height (29). Regarding the relationship between FeNO and genders, Olivieri and colleagues found that there was a difference between the sexes in which women had lower FeNO than men, and this finding was reported in studies (30)(31)(32)(33)(34)(35)(36)(37)(38). On the other hand, many other authors found that this relationship did not exist (29,39,40).…”

Section: Discussionmentioning

confidence: 96%

Correlation between fractional exhaled nitric oxide and Asthma Control Test score and spirometry parameters in on-treatment- asthmatics in Ho Chi Minh City

Nguyen¹,

Chavannes²

2020

J Thorac Dis

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Background: Although fractional exhaled nitric oxide (FeNO) is a reliable and easily applied marker of airway inflammation in asthma, the relationship between FeNO and indicators of asthma control [Asthma Control Test (ACT) score] and/or severity (spirometry parameters) remains unclear. This study aims to determine possible correlations between FeNO and ACT score; and between FeNO and spirometry parameters. Methods: A cross-sectional study with convenience sampling was conducted among ambulatory patients in the Asthma & COPD clinic at the University Medical Center, Ho Chi Minh City from March 2016 to March 2017. Using measurement of FeNO, the ACT questionnaire and a spirometry test, correlations were determined between FeNO and the ACT score and spirometry parameters. Results: Four hundred and ten asthmatic patients (mean age 42 years; 65% female) were included and analyzed; their mean time since onset of asthma was 9.5 years. All patients were treated following step 2 to 4 of GINA guidelines. Mean (SD) FeNO was 29.5 (24.4) parts per billion (ppb) and mean (SD) ACT score was 20.5 (40). A significant difference in FeNO values was found among the three groups with different asthma control levels categorized according to the ACT score (P=0.001) but was not found among the three groups with different asthma treatment levels (P=0.425). FeNO was significantly inversely correlated with the ACT score (Spearman's r =−0.224, P<0.001) and with spirometry parameters indicate airway obstruction such as predicted FEV1, FEV1/FVC, predicted PEF and predicted FEF25-75% with Spearman's r were −0.187; −0.143; −0.091 and −0.195, respectively (all P<0.05), whereas no correlation between FeNO and FVC-an indicator of airway restriction-was found.Conclusions: In these asthmatic patients in Vietnam, an inverse correlation was found between FeNO and the ACT score and between FeNO and spirometry indicators of airway obstruction. Therefore, FeNO may be a useful tool in asthma management.

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Prevalence of high fractional exhaled nitric oxide among US youth with asthma

Cited by 10 publications

References 33 publications

Establishing a patient registry study database of dust mite allergic asthma in children: design, methodology and preliminary exploration

Establishing a patient registry study database of dust mite allergic asthma in children: design, methodology and preliminary exploration

Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III

Correlation between fractional exhaled nitric oxide and Asthma Control Test score and spirometry parameters in on-treatment- asthmatics in Ho Chi Minh City

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