Prevalence of hepatosplenomegaly in beta thalassemia minor subjects in Iran

Karimi, Mehran; Bagheri, Mohammad Hadi; Tahmtan, Mehdi; Shakibafard, Alireza; Rashid, Murtaza

doi:10.1016/j.ejrad.2007.09.027

Cited by 22 publications

(15 citation statements)

References 4 publications

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“…The early studies in Sri Lanka utilised spleen rates, that is the frequency of a palpable spleen, as an indication of malarial infection. Although more recent studies have shown that the spleen may be enlarged in heterozygotes for different forms of thalassaemia, this is only detectable by ultrasonography or related techniques and the spleen is not palpable in these conditions unless there are associated complications, malaria infection for example (Williams et al , ; Premawardhena et al , ; Karimi et al , ). It was found that there was a significant correlation between the early data on spleen rates and the distribution of the haemoglobin variants.…”

Section: Discussionmentioning

confidence: 99%

The evolutionary and clinical implications of the uneven distribution of the frequency of the inherited haemoglobin variants over short geographical distances

et al. 2016

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SummaryStudies of the frequency of heterozygous carriers for common inherited diseases of haemoglobin in over 7500 adolescent children in 25 districts in Sri Lanka have disclosed a highly significant variation over very short geographical distances. A further analysis of these findings, including their relationship to the past frequency and distribution of malaria, climatic variation, altitude, ethnic origin and consanguinity rates, have provided evidence regarding the evolutionary basis for the variable distribution of these conditions over short distances. It is likely that the complex interplay between malaria and the environment, together with related ethnic and social issues, exists in many countries across the tropical belt. Hence, these observations emphasise the importance of micromapping heterozygote distributions in high-frequency countries in order to define their true burden and the facilities required for the prevention and management of the homozygous and compound heterozygous disorders that result from their interaction.

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Section: Discussionmentioning

confidence: 99%

The evolutionary and clinical implications of the uneven distribution of the frequency of the inherited haemoglobin variants over short geographical distances

et al. 2016

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“…Unfortunately, human leukocyte antigen (HLA)‐matched sibling donors are often limited, and an alternative approach is allogeneic HSCT using unrelated donors or HLA‐mismatched donors. However, allogeneic HSCT using unrelated‐ or HLA‐mismatched donors results in developing acute Graft‐versus‐host disease (GVHD) and graft failure (Karimi et al. , 2007).…”

Section: Introductionmentioning

confidence: 99%

Biologic characteristics of bone marrow–derived mesenchymal stem cells from a patient with thalassemia syndrome

Yoon

Kim

Hwang³

et al. 2010

Int J Lab Hematology

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“…Previous studies on splenomegaly in beta thalassaemia minor yielded conflicting results (Weatherall & Clegg, 2001). In our opinion, the combination of these two recent studies (Karimi et al, 2007;Premawardhena et al, 2008) points towards the conclusion that, indeed, the spleen is enlarged in b-thalassaemia minor but usually not to such a degree to be palpable. This was also evident in an older study (Tassiopoulos et al, 1995), in which all beta-thalassaemia heterozygotes had increased splenic volume compared to controls (132AE94 ± 41AE76 mm 3 vs. 80AE29 ± 25AE88 mm 3 respectively) but only 17AE8% of them had a palpable spleen.…”

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confidence: 94%

“…Almost simultaneously, Karimi et al (2007) published their findings concerning the prevalence of splenomegaly in b-thalassaemia minor in 74 cases (and 185 controls), using ultrasonography to calculate splenic volume. They found that splenic volume was significantly increased in thalassaemia trait compared to controls (163AE48 ± 133AE97 mm 3 vs. 126AE29 ± 53AE98 mm 3 respectively, P = 0AE0016).…”

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confidence: 99%