Prevalence of hepatitis G viremia among healthy subjects, individuals with liver disease, and persons at risk for parenteral transmission

Feucht, Heinz‐Hubert; Zöllner, Bernhard; Polywka, Susanne; Knödler, B; Schröter, Matthias; Nolte, Hans; Laufs, Rainer

doi:10.1128/jcm.35.3.767-768.1997

Cited by 66 publications

(40 citation statements)

References 11 publications

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“…Additional persons have antibodies against E2 envelopes protein in the absence of GBV-C RNA, suggesting viral clearance. Epidemiologic studies have shown no association of GBV-C infection with liver disease [15,16], but have demonstrated a delay in disease progression for those co-infected with HIV [17]-an intriguing observation that is not yet fully understood.…”

Section: Non-a To E Hepatitismentioning

confidence: 99%

Emerging infections in transfusion medicine

Fiebig

Busch

2004

Clinics in Laboratory Medicine

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The risk of transfusion-transmitted infectious diseases (TTIDs) has declined dramatically in high-income nations over the past 2 decades, primarily because of extraordinary success in preventing HIV and other established transfusion-transmitted viruses from entering the blood supply. Despite this achievement, TTIDs remain a public health concern, and attention is refocusing on new and emerging pathogens, such as West Nile virus, infectious proteins (the presumed cause of variant Creutzfeldt-Jakob disease), and other transmissible organisms such as bacteria and parasites. In this article the authors concentrate on this heterogeneous group of infectious agents, describe individual pathogens and the risks they pose to transfusion recipients, and comment on existing and evolving procedures that are designed to protect the blood supply from this threat.

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Section: Non-a To E Hepatitismentioning

confidence: 99%

Emerging infections in transfusion medicine

Fiebig

Busch

2004

Clinics in Laboratory Medicine

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“…As HGV shares only 30% of the amino acid sequence of the hepatitis C virus (HCV) it is not another genotype of HCV. In the USA and in Europe, 1-3% of healthy blood donors are infected with HGV [1,4,5]. Its presence in patients with acute post-transfusion hepatitis is rare and limited to single cases.…”

Section: Introductionmentioning

confidence: 99%

Significance of antibodies to the recombinant E2 protein of hepatitis G virus in haemodialysis patients

Schulte‐Frohlinde

Schmolke

Reindl

et al. 1998

Journal of Viral Hepatitis

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Patients on maintenance haemodialysis represent a high-risk group for parenterally transmitted viral infections, such as hepatitis B, C and G. In addition to hepatitis G virus (HGV) (GBV-C) RNA, analysed in previous studies, we characterized the seroprevalence rates of antibodies to the putative E2 protein (anti-E2) of HGV in a German cohort of patients on maintenance dialysis (n = 72) in comparison to healthy blood donors (n = 100). The presence of anti-E2 and/or HGV RNA as indicators of present or past HGV infection could be demonstrated in 34.7% of patients and in 16% of the blood donors (P < 0.01). The infection rates with HGV seem to increase only during the first 6 years of haemodialysis. The simultaneous presence of viraemia and anti-E2 was found very rarely in patients and controls. Therefore, the emergence of anti-E2 indicates clearance of HGV viraemia. In conclusion, patients on haemodialysis are at high risk of acquiring HGV infection, but a chronic carrier state with viraemia is rare. The risk of infection is not strictly correlated with the duration of dialysis.

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“…HPgV-1 can be transmitted through parenteral, sexual, or motherto-child routes. [16][17][18][19] Coinfection with HIV or hepatitis C virus (HCV) is common due to shared transmission modes and also in those exposed to transfused blood products, transplanted patients, injection drug users, hemophiliacs, and patients requiring hemodialysis. 20 In the general population, the prevalence of HPgV-1 ranges from 1% to 4% in North America and Europe and from 5% to 19% in Africa, Asia, and South America.…”

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confidence: 99%

High prevalence and autochtonous transmission of human pegivirus (HPgV‐1) in blood donors in the extreme southern of Brazil

Mota

Finger‐Jardim

Silva

et al. 2018

Journal of Medical Virology

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Recent studies have suggested that human pegivirus 1 (HPgV-1) may have some pathogenic potential. In the southernmost region of Brazil, studies on HPgV-1 are scarce, and circulating genotypes have not yet been identified. The current study aimed to evaluate the prevalence of HPgV-1 among blood donors from the southernmost region of Brazil and identify the genotypes involved with associated factors. A cross-sectional study was conducted with 281 blood donors, who had their plasma subjected to RNA extraction, complementary DNA synthesis, HPgV-1 detection by nested polymerase chain reaction, and subsequent genotyping. The observed prevalence of HPgV-1-RNA was 21.7%. The only variable that was significantly associated with virus infection was the relationship status of the donor. Single or no fixed partner blood donors were twice as likely to have HPgV-1 (95% CI, 1.12 to 4.56; P = 0.02). Genotype 2-subtypes 2b (69%) and 2a (29%)-was the most prevalent. In the absence of risk factors for parenteral transmission, it is likely that sexual transmission was the route of infection in the individuals studied. Further work will be needed to determine whether this virus is inert in the population, or if there are potential deleterious effects in infected individuals.

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Prevalence of hepatitis G viremia among healthy subjects, individuals with liver disease, and persons at risk for parenteral transmission

Cited by 66 publications

References 11 publications

Emerging infections in transfusion medicine

Emerging infections in transfusion medicine

Significance of antibodies to the recombinant E2 protein of hepatitis G virus in haemodialysis patients

High prevalence and autochtonous transmission of human pegivirus (HPgV‐1) in blood donors in the extreme southern of Brazil

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