Prevalence of Hepatitis E Virus Antibodies in Patients with Chronic Hepatitis B and Chronic Hepatitis C

Bayram, Ayşen; Ekşi, Fahriye; Mehli, M.; Sözen, Emrah

doi:10.1159/000103916

Cited by 31 publications

(32 citation statements)

References 58 publications

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“…[36] However, studies could not establish a strong link between these two viral infections and HEV infection in CHD patients although some evidence supports such connection. [25] We also could not demonstrate a considerable correlation between the rate of HBV infection and seropositivity for HEV in the studied patients.…”

Section: Discussioncontrasting

confidence: 65%

“…[1316171921] The HEV seroprevalence rates reported for different countries and CHD patients have been highly variable, ranged as low as 0.9% in France, 2.6% in Italy, and as high as 7.3% or more among adult population in Spain or in Brazil. [22–25] Higher prevalence of anti-HEV antibodies (IgG or IgM) than normal population was found in HD patients from Greece (9.7% vs 0.23%), Japan (9.4% vs 3.7%) or Taiwan (31% vs 8.9%). [26–29] Therefore, high variations in the results have delayed a comprehensive conclusion for the existence of parenteral HEV infection.…”

Section: Discussionmentioning

confidence: 99%

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Serological investigation for hepatitis E virus infection in the patients with chronic maintenance hemodialysis from southwest of Iran

Zekavat¹,

Makarem²,

Karami³

et al. 2013

Asian J Transfus Sci

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Background and Objectives:A global distribution has been shown for hepatitis E virus (HEV) infection. Although the fecal-oral was considered as the primary infection route, there is controversial evidence for increased risk of the infection and consequent problems in patients on maintenance hemodialysis (HD) with suppressed immunity. The aim is to find if the prevalence of anti-HEV IgG, in patients with maintenance HD is higher than normal population in southwest of Iran.Materials and Methods:During November and December 2010, in a cross-sectional study we compared the seroprevalence of HEV among 80 patients with maintenance HD and 276 healthy individuals from Jahrom and Shiraz, Southwest of Iran. In addition to the clinical and laboratory records, serum samples were tested for the presence of IgG anti-HEV antibody by enzyme immunoassay (ELISA) test. The Chi-square, the Student's ‘t’ and Fisher's exact tests were used for the statistical analysis.Results:ELISA tests detected anti-HEV antibody in five males of the patients (6.3%) and in eight of the healthy controls (2.9%, 6 males and 2 female) which statistically were not different. The mean levels of the aspartate aminotransferase and the alanine aminotransferase in the sera of the patients were 19.96±11.08U/L and 23.93±14.26 IU/L, respectively. However, no one of the individuals with positive anti-HEV antibody showed elevated liver enzymes. Moreover, there was not a significant association between positive anti-HEV antibody result, age and the history of the hemodialysis.Conclusions:We did not observe statistically significant higher anti-HEV prevalence among patients with chronic HD; however, more safety precaution is needed to keep HD patients from the risk of possible exposure to HEV infection.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Serological investigation for hepatitis E virus infection in the patients with chronic maintenance hemodialysis from southwest of Iran

Zekavat¹,

Makarem²,

Karami³

et al. 2013

Asian J Transfus Sci

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“…For instance, anti-HEV IgG was detected in Japan significantly in some 23.6% (21/89) of hepatitis B and in 7.9% (12/152) of hepatitis C patients [22]. Various studies have shown that in chronic HCV infection patients, the prevalence rate of HEV infection is higher, too [52,53,54]. An association between the presence of HEV antibody and serological evidence of previous HBV or HCV infections has also been demonstrated [46].…”

Section: Hev Risk Factorsmentioning

confidence: 99%

Hepatitis E Virus Infection: A General Review with a Focus on Hemodialysis and Kidney Transplant Patients

Hosseini-Moghaddam¹,

Abbaszadeh²,

Alavian³

et al. 2010

Am J Nephrol

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Background: Hepatitis E virus (HEV) infection is a self-limited viral disease that causes acute hepatitis epidemics in developing countries. The common route of transmission for HEV is supposedly fecal-oral. Serological evidence may be unexpectedly found in hemodialysis (HD) patients and kidney transplant recipients. Although the route of HEV transmission is not usually determined in HD subjects, this virus seems to be transmitted either directly through HD or nosocomially. In this study, we gathered the published information on HEV infection in HD patients and kidney transplant recipients. Methods: For this review, we collected the relevant articles by searching through Medline and Google Scholar from January 1980 up to September 2009. Results: Some variables including older age, low education, living in rural versus urban areas and the duration of HD seem to be risk factors for HEV infection in HD patients. Compared with non-HD subjects, HEV infection may be specifically associated with poor outcome in HD patients. Specific considerations seem to be required to prevent transmission of HEV to HD patients. Conclusion: More extensive investigations are required to determine the disease burden of HEV infection in HD subjects in countries which experience outbreaks of HEV infection.

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“…Previously investigators have reported the presence of infection by hepatitis viruses in different regions of Iran, but, there aren't enough data about HCV co-infection with HEV in Iran. Previous studies have shown relatively high anti-HEV sero-prevalence in patients with HCV infection: for example Bayram reported 54% (12) and Ludi Koning reported 37%(13) IgG-HEV positive and Zaki reported 52% (14). The current study showed prevalence of IgG-HEV in HCV infected patients about 9.4%.…”

Section: Discussionmentioning

confidence: 99%

Sero-Epidemiology of Hepatitis E Infections in patients with chronic Hepatitis C virus infection in Jahrom, Southern Iran

et al. 2016

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Background and Aims: Co-infection of hepatitis E virus (HEV) in chronic hepatitis C virus (HCV) infected patients can develop and cause an increase in liver disease and hepatic complications in the world. The purpose of this study was to assess the prevalence of HEV infection in patients suffering from chronic HCV infection. Materials and Methods: Cross-sectional study testing anti-HEV antibodies in serum samples belonged to 53 chronic HCV infected patients were evaluated. Demographic and clinical data such as liver function tests and enzymes level were prospectively collected on each patient with chronic HCV infection. Results: There were 5 HEV infected patients IgG positive among the 53 chronic HCV infected patients. These patients had an alanine aminotransferase (ALT) level twice the upper level about of the 48 HEV negative patients (p<0.0001). Conclusions: Prevalence of HEV sero-positivity patients with HCV co-infection patients was 9.4%. Our results suggest that HEV screening should be implemented in HCV-infected patients with cancer.

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Prevalence of Hepatitis E Virus Antibodies in Patients with Chronic Hepatitis B and Chronic Hepatitis C

Cited by 31 publications

References 58 publications

Serological investigation for hepatitis E virus infection in the patients with chronic maintenance hemodialysis from southwest of Iran

Serological investigation for hepatitis E virus infection in the patients with chronic maintenance hemodialysis from southwest of Iran

Hepatitis E Virus Infection: A General Review with a Focus on Hemodialysis and Kidney Transplant Patients

Sero-Epidemiology of Hepatitis E Infections in patients with chronic Hepatitis C virus infection in Jahrom, Southern Iran

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