Prevalence of Hepatitis C Virus (HCV) in Relation to Its Promotive Factors among Human Urban Population of Multan, Pakistan

Ali, Muhammad; Kanwal, Lubna; Tassaduqe, Kamran; Iqbal, Rehana

doi:10.29333/ejgm/82647

Cited by 8 publications

(7 citation statements)

References 19 publications

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“…A detailed study of our results shows that the maximum number of people infected with HCV fall in the age groups between 26 to 55 years in district Swat. These results show similarities to the study of Ali et al [24], Shah et al [11] on the prevalence HCV. But also disagrees to the study that records high HCV occurrence among the younger or older age groups [25].…”

Section: Discussionsupporting

confidence: 91%

Prevalence of Hepatitis C in General Population of District Swat, Khyber Pakhtoonkhwa, Pakistan

Khan¹

2018

J Trop Dis

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The present study was conducted on the prevalence of Hepatitis C in the general population of District Swat, Khyber Pakhtunkhwa province, Pakistan from January 2017 to October 2017. A total of about 1415 individuals were examined, among which 74 (5.22%) were found positive against HCV antibody test. Of the 1415 examined individuals, 759 (53.6%) were males and 656 (46.4%) were females. Among the 74 (5.22%) infected individuals, 32 were females and 42 were males. A maximum number of individuals who were HCV antibody positive belongs to the age group the between 36 to 55 years (21 and 17 i.e. 7% and 6.9%). samples found positive for antibody and antigen-based test, were further investigated for the presence of Hepatitis C related RNA with PCR and the results show that only 32 (2.3%) individuals have Hepatitis C viral RNA. This is about (43.24%) of the total HCV antibody positive individuals. Out of 32 HCV-PCR positive samples, 11 (34.4%) were symptomatic and 21 (65.6%) were asymptomatic. Further analysis of the PCR positive samples shows that 20 (62.5%) were females and 12 (37.7%) were male. Among the HCV positive samples, genotype 3a was the most abundant 18 (56.2%) of the infected individuals followed by genotype 3b in 4 female (20%) and 3 male (25%), genotype 2a in 3 females (15%) and 2 male (16.6%), and 1b in 1 (5%) females and 1 (8.3%) male. No unknown RNA sequences were found in the studied samples.

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Section: Discussionsupporting

confidence: 91%

Prevalence of Hepatitis C in General Population of District Swat, Khyber Pakhtoonkhwa, Pakistan

Khan¹

2018

J Trop Dis

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“…Along with this, the unclean dental equipment is common in almost every dental clinic of Pakistan (Ali et al, 2009a). In our study, it was found that most of the people infected with hepatitis C were health care workers because they have a higher risk of getting hepatitis C virus through contact with the blood and blood products of the patients.…”

Section: Discussionmentioning

confidence: 80%

“…Infectious diseases including Hepatitis C are major health issues in various developing countries including Pakistan (Ali et al, 2009a;Khan and Siddiqui, 2007). According to an estimate of the World Health Organization, hepatitis C has effected almost 3% population of the world, an estimate of 170 million people, with an increase in three to four million new cases every year (Raza et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…In Pakistan, the major ways of hepatitis C virus transmission are the contaminated instruments use in medical practice, unscreened blood and blood product transfusion, the uses of intravenous drugs, barber shops, piercing of ear and nose, unhygienic habits and poor medical practice by non-qualified people (Ali et al, 2009a;Raja and Janjua, 2008;Zuberi et al, 2008). Among them, one of the major transmission route is lack of proper screening of the transfusing blood (Luby et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Hepatitis C virus infections among the general population of Buner, Khyber Pakhtunkhwa, Pakistan

et al. 2016

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Introduction: In the current study, prevalence of hepatitis C virus and its routes of transmission were determined in district Buner, Khyber Pakhtunkhwa, Pakistan. Methods: Total 230 blood samples for HCV were collected from 7 tehsils of District Buner. Diaspot rapid HCV strips manufactured by Diaspot diagnostic USA were used for the detection of HCV-Ab in the blood. Results: Out of 230 blood samples collected from patients, 158 were found positive for HCV infection. Of the 158 positive cases, 102 (64.55%) were male and 56 (35.45%) were female patients. The high rate of Hepatitis C infection was found in the age group of 41-50 years that was 68 (29.56%), followed by age group of 20-30 years that was 60 (26.08%), 31-40 years that was 54 (23.47%). The lowest infection was found in age group above 70 years. Conclusion: It is concluded from the study that such high proportion of hepatitis C prevalence will result in high rate of mortality and morbidity in the area. Possible steps are required for the prevention and cure of such viral infections.

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“…Possible routes of transmission of HCV genotypes among the subjects. 21,22 The reason could be prognosis of HCV and awareness of health department of the region to aware them. Current study observed that untypable genotypes was the most predominant (43.5%), followed by 3a (29.6%) 3 b (9.6%), 2a (5.93%), 1a (5.3%), 1 b (4.0%), and 2 b (1.9%) genotype in district Buner population (table.No2) as noticed in the available literature when compiled showed that HCV genotype 3a (58.16%) was predominant in Pakistan, followed by 3 b (9.05%), 2a (6.70%), 1a (6.22%), and 1 b (2.39%), the findings of the study disagreed to our findings.…”

Section: Tablementioning

confidence: 99%

Prevalence of Hepatitis C virus and determination of its genotypes in subjects of Tehsil Daggar District Buner, KP, Pakistan

Qamar

Anwar

Ahmad³

et al. 2021

Clinical Epidemiology and Global Health

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Background: Hepatitis C is a noteworthy public health issue around the globe, resulting in liver-related problems. The disease is caused Hepatitis C virus a positive sense RNA virus belongs to Flaviviridae family. Approximately 6% population of Pakistan is infected with HCV. Due to genetic variation, HCV is categorized into 7 genotypes and 67 subtypes. Methodology: In this study total 1100 ICT positive samples were collected from December 2016 to May 2017 from Tehsil Dagger District Buner. RNA was extracted from ICT positive serum samples of 1100 patients and, were screened for HCV-RNA by using Reverse Transcriptase-Nested polymerase chain reaction (RT-nested PCR) and, then the positive samples were subjected for HCV genotyping. Statistical analysis was carried on SPSS version 10.0. Results: Out of 1100 ICT positive samples, HCV RNA was detected in 375 individuals, of which 14.9% were males and, 19.2% females. The frequency of HCV genotypes Untypable was 43.5%), followed by 3a (29.6%), 3 b was 9.6%, 2a was 5.9%, 1a was 5.3%, 1 b (4.0%) and, 2 b was 1.9% in these patients. Both genotypes untypable and 3a were the most prevalent genotypes in patients of all age groups and its prevalence was found high among patients with increasing age (>30years). The prevalence rate of HCV in age of 21-30 years (30.1%), of 31-40 years the percentage of positive cases are 24.85% and 11-20 years of age group is (11.4%). Furthermore, genotypes untypable, 3a and 3 b were found to be the most common genotypes in patients with history of barber shops, dental surgery, and receiving multiple injections. Conclusion:The current study reveals HCV untypable variants as the most frequent genotypes in the HCV patients of district Buner KP, Pakistan, with most patients in the age group 21-30 years. HCV various isolates were associated with different routes of transmission. The predominant factors of HCV included shaving in barber shops and intra-venous drugs use. These findings may suggest anti-HCV therapy and monitoring HCV infections.

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Prevalence of Hepatitis C Virus (HCV) in Relation to Its Promotive Factors among Human Urban Population of Multan, Pakistan

Abstract: Aim:The present study was carried out to assess the prevalence of hepatitis C virus (HCV)

Cited by 8 publications

References 19 publications

Prevalence of Hepatitis C in General Population of District Swat, Khyber Pakhtoonkhwa, Pakistan

Prevalence of Hepatitis C in General Population of District Swat, Khyber Pakhtoonkhwa, Pakistan

Prevalence of Hepatitis C virus infections among the general population of Buner, Khyber Pakhtunkhwa, Pakistan

Prevalence of Hepatitis C virus and determination of its genotypes in subjects of Tehsil Daggar District Buner, KP, Pakistan

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