Prevalence of hepatitis C virus infection among hemodialysis patients in the Middle-East: A systematic review and meta-analysis

Ashkani-Esfahani, Soheil; Alavian, Seyed Moayed; Salehi-Marzijarani, Mohammad

doi:10.3748/wjg.v23.i1.151

Cited by 55 publications

(51 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings may indicate overlapping transmission networks where HCV is circulating from one population to another through different modes of exposure including dialysis. A review of HCV among HD patients in the Middle East has been recently published [208]. Its findings agreed overall with our findings despite differences between the two studies in the focus, scope, and analysis plans.…”

Section: Discussionsupporting

confidence: 82%

“…Our study covered more countries in MENA over a longer duration, examined analytically trends and associations, and reported a broader set of outcome measures and analyses (such as for the genotype distribution). In total, 205 studies were included in our analyses compared to 56 studies in Ashkani-Esfahani et al study [208]. Both studies concluded that there is high HCV prevalence in HD patients that needs to be addressed through targeted interventions.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology of hepatitis C virus among hemodialysis patients in the Middle East and North Africa: systematic syntheses, meta-analyses, and meta-regressions

et al. 2017

View full text Add to dashboard Cite

SUMMARYWe aimed to investigate hepatitis C virus (HCV) epidemiology among hemodialysis (HD) patients in the Middle East and North Africa (MENA). Our data source was an HCV biological measures database populated through systematic literature searches. Descriptive epidemiologic syntheses, effects meta-analyses and meta-regressions, and genotype analyses were conducted. We analyzed 289 studies, including 106 463 HD patients. HCV incidence ranged between 0 and 100% as seroconversion risk, and between 0 and 14·7 per 1000 person-years as incidence rate. The regional pooled mean estimate was 29·2% (95% CI: 25·6-32·8%) for HCV antibody positive prevalence and 63·0% (95% CI: 55·4-70·3%) for the viremic rate. Region within MENA, country income group, and year of data collection were associated with HCV prevalence; year of data collection adjusted odds ratio was 0·92 (95% CI: 0·90-0·95). Genotype diversity varied across countries with four genotypes documented regionally: genotype 1 (39·3%), genotype 2 (5·7%), genotype 3 (29·6%), and genotype 4 (25·4%). Our findings showed that one-third of HD patients are HCV antibody positive and one-fifth are chronic carriers and can transmit the infection. However, HCV prevalence is declining. In context of growing HD patient population and increasing HCV treatment availability, it is critical to improve standards of infection control in dialysis and expand treatment coverage.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Epidemiology of hepatitis C virus among hemodialysis patients in the Middle East and North Africa: systematic syntheses, meta-analyses, and meta-regressions

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The prevalence rate of HCV infection ranges between 5% and 60%, and different prevalence rates have been reported by different countries for HD patients (4). Seroprevalence rates of HCV infection reported among HD patients in the Middle East included 35% in Jordan, 12% in Iran, 19% in Saudi Arabia, and 23% in Turkey (5). The preva-lence rate of HBV infection in Tehran is between 0% and 58% (6); while in Turkey, it is 7.21% (7) to 50% (8).…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Prevalence of HBV, HCV, and HIV in Hemodialysis Patients in North Cyprus

et al. 2019

View full text Add to dashboard Cite

Background: Patients undergoing dialysis treatment and hemodialysis are at risk of viral infections due to inadequate cellular immunity. Objectives: The aim of the study was to determine the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) in hemodialysis (HD) centers in North Cyprus. Methods: The present study reviewed the health records of 140 patients in two dialysis units that represented all HD units in North Cyprus. Serological markers for HBV, HCV, and HIV were determined by the immunoenzymatic assay using commercial diagnostic kits (Architect i2000 SR, Abbott, USA). HCV RNA, HBV DNA, and HIV RNA were determined quantitatively using polymerase chain reaction (PCR). Results: One hundred forty HD patients were included in the study, consisting of 39.3% (n = 55) female and 60.7% (n = 85) male patients. Five (3.6%) patients were anti-HCV positive, one (0.7%) patient was HBsAg positive, and one (0.7%) was anti-HIV positive. Anti-HCV and HBsAg were negative in all of the patients according to the PCR results. There were no significant differences between males (1.2%) and females (7.3%) in terms of anti-HCV positivity (P = 0.078), HBsAg seropositivity (P = 0.607), and anti-HIV seropositivity (P = 0.607). Conclusions: The prevalence of HBV, HCV, and HIV infection in hemodialysis patients in North Cyprus is moderate to low. The main reason for the significantly lower rates compared to other areas could be effective protective measures and national vaccination.

show abstract

“…In a systematic review from Middle-East, the highest prevalence was seen in Syria (54%) and Egypt (50%), lowest in Iran (12%) and Lebanon (9%). 16 However, in a prospective study at two centers in Kathmandu, Nepal, during 2005Nepal, during -2006, there was no seroconversion reported. 17 In a multicenter study involving 2796 patients in Germany, the hepatitis C prevalence was 7%.…”

Section: Discussionmentioning

confidence: 95%

Hepatitis C sero-prevalence and risks of transmission in end-stage renal failure patients undergoing hemodialysis

Manandhar

Acharya²,

Sharma³

et al. 2018

J Patan Acad Health Sci

View full text Add to dashboard Cite

Introductions: Hepatitis C virus (HCV) infection is common in the patients undergoing hemodialysis (HD). The quality of life and survival of patients with hepatitis C infected end-stage renal disease is less than that of the noninfected ones. This study aims to determine the prevalence of HCV in patients undergoing HD and the risk of transmission. Methods: This was a retrospective study of charts of the chronic kidney disease patients who underwent dialysis at Patan Hospital from March 2011 to July 2017. Those patients who were positive for HIV, HBsAg and HCV before the initiation of dialysis were excluded. Pearson Chi square test and Fisher’s Exact test were used to determine the significance of the results. Results: Out of 173 patients, 12 (6.9%) seroconverted to HCV: five (41.66%) in first year, four (33.33%) in second year, and three (25%) in third year (Fisher’s Exact test p=0.26). Out of 173 patients, 137 (79.2%) received blood transfusion, 27 (15.6%) received erythropoiesis stimulating agent (ESA), 9 (5.2%) received both blood transfusion and ESA. The HCV seropositivity were 9 (75%), 2 (16.66%), and 1 (8.33%) respectively in them, Fisher’s Exact test p value was 0.65. There was no significant association between the seroconversions in in-center versus multicenter HD and the number of dialyses per week. Conclusions: Hepatitis C infection was common (6.9%) in HD patients. There was no significant association of transmission in regards to duration of HD, transfusion or single vs multicentre HD.

show abstract

Prevalence of hepatitis C virus infection among hemodialysis patients in the Middle-East: A systematic review and meta-analysis

Abstract: Controlling the prevalence and improving the management methods of HCV infection among hemodialysis patients are of a great concern in the Middle-East region.

Cited by 55 publications

References 92 publications

Epidemiology of hepatitis C virus among hemodialysis patients in the Middle East and North Africa: systematic syntheses, meta-analyses, and meta-regressions

Epidemiology of hepatitis C virus among hemodialysis patients in the Middle East and North Africa: systematic syntheses, meta-analyses, and meta-regressions

Evaluating the Prevalence of HBV, HCV, and HIV in Hemodialysis Patients in North Cyprus

Hepatitis C sero-prevalence and risks of transmission in end-stage renal failure patients undergoing hemodialysis

Contact Info

Product

Resources

About