Prevalence of hepatitis C virus infection and human immunodeficiency virus in a cohort of Egyptian hemophiliac children

Abdelwahab, Magy; El-Raziky, Mona; Kaddah, Normine A; Abou-Elew, Heba Hassan

doi:10.5144/0256-4947.2012.200

Cited by 13 publications

(8 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The significant association between previous blood transfusion& occurrence of HCV infection, is in agreement with that reported by Abdelwahab et al (2012) (22) who stated that HCV prevalence rates are higher among previously transfused patients. This might be before the era of blood testing for viruses in blood banks or the blood donor carrying HCV virus but in the incubation period which not appear in the laboratory testing (false negative HCV-Ab by ELISA).…”

Section: Discussionsupporting

confidence: 82%

Prevalence of Hepatitis C Infection among Diabetics Type 2 at Sharkia Governorate, Egypt

2015

IJSR

View full text Add to dashboard Cite

Background: HCV infection and type 2 diabetes mellitus are two chronic conditions which contribute to a significant morbidity and mortality. Egypt has the highest hepatitis C virus (HCV) prevalence in the world (14.7%). The drivers of the HCV epidemic in Egypt are not well understood, but the mass parenteral antischistosomal therapy (PAT) campaigns in the second half of the 20th century are believed to be the determinant of the high prevalence. The mutual relationship between diabetes and increased HCV infection may be due to the association of HCV with hepatic steatosis, insulin resistance and decrease of adiponectine synthesis as well as the nature of diabetes and its inherent complications and/or frequent parental exposure. Objective: There are many studies in the past done on frequency of diabetes in HCV infection and the average was 13.84% prevalence of type 2 diabetes mellitus in HCV seropositive patients, but little number of studies evaluated the prevalence of HCV in diabetics. Our aim is to determine the prevalence of HCV infection in diabetics in Sharkia Governorate and to explore the predominant risk factors for HCV infection and its relation to some demographic parameters of this locality. Subjects and methods: A cross sectional randomized study was conducted to 642 patients, regardless of gender, body weight, educational level or socioeconomic levels, at multicentre managing diabetic patients at Sharkia governorate. All patients were subjected to detection of HCV-ab by third generation ELISA and HBA1C level. Results: The prevalence of HCV infection among diabetic patients at Sharkia governorate approximates 38.7 %. Higher prevalence was detected among patients between 45 & 65 years old, low socioeconomic level, low educational level, those who shared personal utensils, those with family members infected with HCV, patients who previously transfused, previous hospitalized, previously received parenteral anti-bilharzial therapy and those receiving insulin injections. Conclusion: As high as 39% of diabetic patients at Sharkia Governorate are HCVinfected. Apart from classic risk factors, the most significant independable factors associated with development of HCV infection in diabetic patients are low socioeconomic standard and low educational level. Previous blood transfusion, family members infected with HCV, parenteral antibilharzial treatment, sharing personal utensils and previous hospitalization may play also a role.

show abstract

Section: Discussionsupporting

confidence: 82%

Prevalence of Hepatitis C Infection among Diabetics Type 2 at Sharkia Governorate, Egypt

2015

IJSR

View full text Add to dashboard Cite

show abstract

“…This result is in agreement with that reported by Arafa et al (2005) (19) who concluded that Community and informal health provider related exposures were associated with increased HCV infection. The significant association between previous blood transfusion& occurrence of HCV infection, is in agreement with that reported by Abdelwahab et al (2012) (22) who stated that HCV prevalence rates are higher among previously transfused patients. This might be before the era of blood testing for viruses in blood banks or the blood donor carrying HCV virus but in the incubation period which not appear in the laboratory testing (false negative HCV-Ab by ELISA).…”

Section: Hepatitis C Virus (Hcv) Infection Is a Major Public Health Csupporting

confidence: 82%

Prevalence of Hepatitis C Infection Among Diabetics Type 2 at Sharkia Governorate, Egypt

Amin¹,

Ghorab²,

Mohamed³

et al. 2015

Zagazig University Medical Journal

View full text Add to dashboard Cite

Background: HCV virus infection and type 2 diabetes mellitus are two major public health problems in Egypt. Egypt has the highest HCV virus prevalence in the world and is considered the ninth in rank of the highest prevalence of diabetes worldwide. The mutual relationship between diabetes and increased HCV infection may be due to the association of HCV with hepatic steatosis, insulin resistance and decrease of adiponectine synthesis as well as the nature of diabetes and its inherent complications and/or frequent parental exposure. Objective: determination of the prevalence of HCV infection in type-2 diabetics in Sharkia Governorate and to explore the predominant risk factors for HCV infection and its relation to some demographic parameters of this locality. Subjects and methods: A cross sectional randomized study was conducted to 642 patients, regardless of gender, body weight, educational level or socioeconomic levels, at multicentre managing diabetic patients at Sharkia governorate. All patients were subjected to detection of HCV-ab by third generation ELISA and HBA1C level Results:The prevalence of HCV infection among type 2 diabetic patients at Sharkia governorate approximates 38.7 %. Higher prevalence was detected among patients between 45 & 65 years old, low socioeconomic level, low educational level, and those who share personal utensils, have other family members infected with HCV. Patients who previously transfused, previous hospitalized, previously received parenteral anti-bilharzial therapy and those receiving insulin injections are also at high risk. Conclusion: As high as 39% of type-2 diabetics at Sharkia Governorate are HCV-infected. Apart from classic risk factors, The most significant independable factors associated with development of HCV infection in type 2 diabetics are low socioeconomic standard and low educational level. Previous blood transfusion, family members infected with HCV, parenteral antibilharzial treatment, sharing personal utensils and previous hospitalization may play also a role.

show abstract

“…High prevalence levels were reported among subpopulations such as hemodialysis patients (range = 27.1–98%; median = 67.5%), multi-transfused patients (range = 17.6–54.9%; median = 38.2%), and thalassemia patients (range = 8.9–82%; median = 50.0%). A single study among hemophilic children reported anti-HCV prevalence at 40.0% 63 . The only study among PWID assessed anti-HCV prevalence at 63% 64 .…”

Section: Resultsmentioning

confidence: 99%

“…HCV viremic rate was reported among the general population (range = 26.9–100%; median = 65.3%; Supplementary Table S2 ) and its subpopulations including children (range = 33.3–75.9%; median = 41.0%), pregnant women (range = 26.9–79.0%; median = 55.1%), and other general populations (range = 29.7–100%; median = 69.5%). Among populations at high risk (Supplementary Table S3 ), HCV viremic rate was reported among thalassemia patients (range = 55–100%; median = 74.3%), and was measured at 100% 143 among multi-transfused children, and at 47.5% 63 among hemophilic children.…”

Section: Resultsmentioning

confidence: 99%

Characterizing hepatitis C virus epidemiology in Egypt: systematic reviews, meta-analyses, and meta-regressions

Kouyoumjian

Chemaitelly

Abu‐Raddad

2018

Sci Rep

163

173

View full text Add to dashboard Cite

Egypt is the most affected nation by hepatitis C virus (HCV) and needs a comprehensive characterization of HCV epidemiology to inform the scale-up of treatment and prevention programs. Systematic reviews, meta-analyses, and meta-regressions were conducted. A total of 25 incidence, 259 prevalence, and 47 genotype studies were identified. Incidence and prevalence levels were high across all populations. Genotype 4 accounted for 94.1% of infections with a relative Shannon Diversity Index of only 14.4%. Pooled mean HCV prevalence was estimated at 11.9% (95% CI = 11.1–12.6%) among the general population, 55.6% (95% CI = 49.4–61.7%) among populations at high risk, 14.3% (95% CI = 10.3–18.8%) among populations at intermediate risk, 56.0% (95% CI = 50.4–61.6%) among populations with liver-related conditions, and 35.0% (95% CI = 27.3–43.1%) among special clinical populations. Mean HCV viremic rate was estimated at 66.7% (95% CI = 61.7–71.5%). Meta-regression indicated 6% lower odds for HCV prevalence for each one-year increment in publication year (AOR = 0.94; 95% CI = 0.92–0.96). HCV prevalence is high with evidence for ongoing transmission mainly through healthcare. Genotype diversity is low with genotype 4 dominance. Two-thirds of antibody-positive Egyptians are chronically infected and need treatment. Clinical populations should be prioritized for screening. Despite the large-scale epidemic, prevalence appears to be declining rapidly consistent with a contracting epidemic.

show abstract

Prevalence of hepatitis C virus infection and human immunodeficiency virus in a cohort of Egyptian hemophiliac children

Cited by 13 publications

References 15 publications

Prevalence of Hepatitis C Infection among Diabetics Type 2 at Sharkia Governorate, Egypt

Prevalence of Hepatitis C Infection among Diabetics Type 2 at Sharkia Governorate, Egypt

Prevalence of Hepatitis C Infection Among Diabetics Type 2 at Sharkia Governorate, Egypt

Characterizing hepatitis C virus epidemiology in Egypt: systematic reviews, meta-analyses, and meta-regressions

Contact Info

Product

Resources

About