Prevalence of hepatitis C Virus infection among hemophiliacs in Central Brazil

Barbosa, Adriana P.; Martins, Regina Maria Bringel; Teles, Sheila Araújo; Silva, Simonne A.; Oliveira, Jaqueline Mendes de; Yoshida, Clara Fumiko Tachibana

doi:10.1590/s0074-02762002000500009

Cited by 20 publications

(16 citation statements)

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“…Prior to these developments, the HCV and HBV infection rates in hemophilic patients in Poland were high (95% of those who were anti-HCV positive, 8.7% of HBsAg, and 68% of anti-HBc positive) (2), whereas the rates observed in the general population were significantly lower (anti-HCV was 0.6% - 2.1% and HBsAg was about 1%) (15-19). Our results were comparable with the rates observed among hemophiliacs in the USA and Western European countries (3, 4, 10, 20). …”

Section: Discussionsupporting

confidence: 89%

Co-Infection of the Hepatitis C Virus With Other Blood-Borne and Hepatotropic Viruses Among Hemophilia Patients in Poland

et al. 2016

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BackgroundThe prevalence of HCV infection in people with hemophilia is substantially higher than that in the general population (63% - 98%). Multiple transfusions and substitutive therapy have also been linked to a high risk of HBV and HIV transmission. However, the prevalence of other blood-borne viral infections in this population is less well known.ObjectivesThis study aimed to assess the prevalence of co-infection with HBV and other blood-borne viruses in Polish HCV-infected hemophiliacs.MethodsSeventy-one individuals, the majority of whom were male (94.36%), who had congenital bleeding disorders (60 had hemophilia A, five had hemophilia B, and six had other factor deficiencies) and HCV infection, which was defined as the presence of positive anti-HCV antibodies, were included in this study. The study group was divided into two subgroups according to the year in which blood donors were first tested for HBsAg in Poland. The serological markers were screened using commercially available enzyme immunoassays according to the manufacturer’s instructions. The molecular tests were performed using real-time PCR technology with commercial assays according to the manufacturer’s instructions.ResultsThe spontaneous elimination rate of HCV RNA was 29.6%. The HCV genotype 1 was detected in 28 patients (65.1%), genotype 2 in one patient (2.3%), genotype 3 in 11 patients (25.6%), genotype 4 in two patients (4.7%), and a mixed infection with genotypes 1 and 4 was detected in one person (2.3%). Fifty-three patients (74.6%) were anti-HBc positive. Among the seven HBsAg(+) patients, three individuals were HBV-DNA positive. No occult hepatitis B was detected. In six HBsAg positive patients, the HCV RNA was positive, while one patient was also infected with HIV. The prevalence rate of past infection with HAV in the study group was 30.9%, with a tendency for a higher prevalence in older patients. The prevalence of CMV and EBV infection was high and similar to that seen in the general population. All the patients were HGV and HTLV-1 negative.ConclusionsThe diagnostics and management of infections with hepatotropic viruses, particularly HBV, are neglected in hemophilic patients. All patients with coagulation disorders and a history of exposure to non-inactivated blood products should be screened for blood-borne infections. The prevalence of other potentially blood-borne viral infections exhibited a pattern similar to that observed in the general population.

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Section: Discussionsupporting

confidence: 89%

Co-Infection of the Hepatitis C Virus With Other Blood-Borne and Hepatotropic Viruses Among Hemophilia Patients in Poland

et al. 2016

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“…Other Iranian studies have reported the prevalence of HCV in hemophilia patients as follows: Ahvaz 54 % (Assarehzadegan et al 2012 (Alavian et al 2003), and Bushehr 41.9 % (Rezvan et al 2007). Furthermore, the anti-HCV prevalence in our study was lower than Pakistan (56 %) (Waheed et al 2009), India (23.9 %) (Ghosh et al 2000), Brazil (60 %) (Barbosa et al 2002), and some neighboring Arabic countries (66-79 %) (Bahakim et al 1991;Al-Kubaisy et al 2006). Similar study conducted on 367 hemophilia patients in Shiraz (1992Shiraz ( to 2002 was also reported 15 % HCV seropositivity (Karimi et al 2002).…”

Section: Discussionmentioning

confidence: 44%

Prevalence of hepatitis B, hepatitis C, and human immunodeficiency virus infections among hemophilia patients in Shiraz, south of Iran

et al. 2016

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Transfusion-transmitted viral infections, including hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) infections continue to be a major challenge in hemophilia patient. This study was conducted to assess the seroprevalence of HBV, HCV, and HIV infections among Iranian hemophilia patients. A cross-sectional study was conducted on 580 hemophilia patients (mean age ± SD = 27.11 ± 14.9) referred to the Namazi hospital, Shiraz University of medical sciences, Shiraz, Iran during July 2012 to August 2015. Blood samples were taken from the patients and tested for HBV surface antigen (HBsAg), antibody to HBV surface antigen (anti-HBs), antibody to HBV core antigen (anti-HBc), anti-HCV antibody (HCVAb), and anti-HIV antibody (HIVAb). The association of HBV, HCV, and HIV infections with age, sex, type of hemophilia (A or B), severity of hemophilia, blood group system, history of blood transfusion, and surgery were statistically analyzed using SPSS software and chi-square/Fisher exact tests. The seroprevalence of HCVAb and HBsAg were 11.4 % (66/ 580) and 0.2 % (1/580), respectively. None of the hemophilia patients were positive for HIV antibody. There was a significant association between HCV seropositivity and age (P < 0.001), severity of hemophilia (P < 0.0001), and history of blood transfusion (P = 0.050). It seems that strategies for prevention of HBV and HIV infections have been successful in south of Iran, but HCV is still a major infection of concern in multi-transfused patients.

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“…In a previous study conducted on hemophiliac patients from Goiânia, subtype 1a (41%) was also dominant, followed by subtypes 1b (25.6%) and 3a (20.5%) (18). Among blood donors, subtype 1a (54.6%) was also the most frequent, but subtype 3a (31.8%) was detected more frequently than subtype 1b (9.1%) (19).…”

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confidence: 77%

Hepatitis C virus seroprevalence and genotypes in patients with diffuse connective tissue diseases and spondyloarthropathies

Barbosa

Silva

Martins

2005

Braz J Med Biol Res

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Many extrahepatic manifestations, including rheumatic diseases, have been reported to be associated with hepatitis C virus (HCV) infection. In order to investigate the prevalence of HCV infection among patients with rheumatic diseases, in the present study we interviewed 367 patients and tested their blood samples for HCV antibodies (anti-HCV) by an enzyme-linked immunosorbent assay. Anti-HCV-reactive samples were retested for confirmation by a line immunoassay and also for HCV RNA detection by the polymerase chain reaction. HCV RNA-positive samples were genotyped by INNO-LIPA. An overall HCV infection prevalence of 1.9% (7/367) was found. Of the 7 HCV-infected patients, 4 had systemic lupus erythematosus and 3 rheumatoid arthritis, resulting in positivity rates of 2.3 and 3.4%, respectively. HCV RNA genotyping revealed the presence of subtypes 1a (57.1%), 1b (28.6%) and 3a (14.3%). The clinical course was favorable for all HCV-infected patients, except one, who died due to renal insufficiency related to lupus nephritis. These results demonstrate a low HCV infection prevalence among the population studied. In the few positive cases, we observed no adverse influence of this infection on the clinical evolution of the rheumatic disease.

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Prevalence of hepatitis C Virus infection among hemophiliacs in Central Brazil

Abstract: In order to investigate the hepatitis C virus (HCV) infection prevalence and risk factors in hemophiliacs in

Cited by 20 publications

References 8 publications

Co-Infection of the Hepatitis C Virus With Other Blood-Borne and Hepatotropic Viruses Among Hemophilia Patients in Poland

Co-Infection of the Hepatitis C Virus With Other Blood-Borne and Hepatotropic Viruses Among Hemophilia Patients in Poland

Prevalence of hepatitis B, hepatitis C, and human immunodeficiency virus infections among hemophilia patients in Shiraz, south of Iran

Hepatitis C virus seroprevalence and genotypes in patients with diffuse connective tissue diseases and spondyloarthropathies

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