Prevalence of Hepatitis C Among Psychiatric Patients in the Public Sector

Dinwiddie, Stephen H.; Shicker, Louis; Newman, Tom

doi:10.1176/appi.ajp.160.1.172

Cited by 77 publications

(58 citation statements)

References 7 publications

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“…Previous results showed that the rates of exposure to HBV and HCV infection among psychiatric patients were significantly higher than the estimated general population rates [17][18][19][20][21]. A study by Dinwiddie et al reported that 27.8% patients had HBsAb and 8.5% had HCV RNA of 1,556 psychiatric patients [20].…”

Section: Discussionmentioning

confidence: 98%

“…A study by Dinwiddie et al reported that 27.8% patients had HBsAb and 8.5% had HCV RNA of 1,556 psychiatric patients [20]. In Japan, Sawayama et al studied 196 neuropsychiatric patients and found that 10.2% of the patients were HCV antibody positive compared to 1.5% of controls and 44.4% were HBcAb positive compared to 20.5% of controls [21].…”

Section: Discussionmentioning

confidence: 99%

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Seroepidemiology of hepatitis B virus infection among Chinese schizophrenia patients

Zhu

Liu

Xue

et al. 2015

J Infect Dev Ctries

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Introduction: This study aimed to analyze the characteristics of HBsAg, HBsAb, coexistence of HBsAg and HBsAb, and the genotypic distribution of HBV in Chinese schizophrenia patients. Methodology: A total of 1,694 schizophrenia patients, 9-85 years of age, were recruited for the present study. HBsAg, HBsAb, and HBV DNA were detected with commercial methods. ALT, AST, γ-GT, TBIL, and IBIL were measured by an automatic biochemistry analyzer. All statistical analyses were performed with SPSS 13.0. Results: The seroprevalence of HBsAg and HBsAb in 1,649 schizophrenia patients was 11.0% and 54.6%, respectively. HBsAb seroprevalence significantly decreased with the duration of the disease (p = 0.0009). The lowest seroprevalence of HBsAg was determined in 9.4% of the patients who had had the illness for < 1 year, and then increased to 11.7%, 11.3% and 11.7% in the patients who had had the illness for 1-5 years, 6-10 years and > 10 years. HBsAg and HBsAb coexisted in 69 individuals, which comprised 4.2% of the total subjects, and in 38.1% of the HBsAg-positive patients. Additionally, HBV titers were quantified in 64 HBsAg-positive samples; the highest virus titer was 6.14×10 8 copies/mL, while 12 patients had less than 500 copies/mL. Moreover, among 48 HBV strains isolated from 62 HBsAg-positive samples, 33 and 15 strains belonged to genotypes C and B, respectively. Conclusion: Genotypes B and C HBV were the dominant genotypes distributed in schizophrenia patients, and the HBsAb seroprevalence significantly decreased with illness duration. Effective prevention strategies for against HBV transmission are required.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Seroepidemiology of hepatitis B virus infection among Chinese schizophrenia patients

Zhu

Liu

Xue

et al. 2015

J Infect Dev Ctries

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“…1 Groups of increased risk of infection also include non-intravenous drug users, patients with highrisk sexual practices, and patients admitted to a psychiatric hospital. 11 It is being estimated that the infection is in 65-70% transmitted through injection drug use, 15-20% high-risk sexual behaviors and 5% occupational exposure. 12 Penitentiary institutions have an especially high prevalence of HCV, even 17-21% of inmates are infected.…”

Section: Virus Prevalence Risk Factorsmentioning

confidence: 99%

The neuropsychiatric aspect of the HCV infection

Więdłocha¹,

Marcinowicz²,

Sokalla³

et al. 2017

Adv Clin Exp Med

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HCV infection is significantly more prevalent in the population of psychiatric patients, drug addicts and people tending to undertake risky sexual behaviors than in the general population. This article presents a spectrum of psychopathological symptoms and psychological dysfunctions, an outline of current theories on the neuropathology and psychiatric aspects of HCV infection treatment. The unspecific character of the psychopathological symptoms in the HCV infection makes the process of thorough diagnostics and adequate treatment difficult, thus the specific and characteristic features have been emphasized. The aim of this review is to shed light not only on the basic information concerning CNS pathology but also on the conclusions emerging from the studies of different authors, of various methodology, in diverse study groups and also to investigate current topics of research. The results of neuroimaging studies have been presented as well. Attention has also been dedicated separately to specific issues, like psychiatric aspects of co-infection with HCV and HIV viruses, the chronic fatigue in the course of HCV infection, the influence of substance use disorders and difficulties encountered during treatment with interferon. Undiagnosed psychiatric disorders, not only inevitably decrease the already rather low quality of life but also cause non-adherence with recommendations and medications regimes, contributing to a worse treatment outcome. Finally, the above disorders, when left untreated, result in higher rates of risk-taking behaviors among the infected, thus imposing a danger not only to patients themselves but also to the healthy population.

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“…In the USA, estimates of HCV infection in cohorts of patients with severe mental illness have ranged from 8.5% to 19.6% (Rosenberg 2001;Dinwiddie 2003). One US study reported that 10.5% of inpatients with psychosis were positive for hepatitis C (Al-Jurdi 2003).…”

Section: Risk Factors For Hcv Infectionmentioning

confidence: 99%

“…Given the observed prevalence of HCV infection in patients admitted with serious mental illness to a US psychiatric hospital, Dinwiddie et al (2003) recommend routine screening as a reasonable option in this population. Such testing, which should target people with risk factors for acquiring HCV, should be accompanied by pre-and post-test counselling, as a diagnosis of HCV infection can have a very negative impact on pre-existing depression.…”

Section: Hcv Diagnosis From a Psychiatrist's Perspectivementioning

confidence: 99%

Hepatitis C: a patient's journey from a psychiatrist's perspective

Badrakalimuthu¹,

Rumball²,

Chawla³

2011

Adv. psychiatr. treat

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SummaryThere is an increasing prevalence of hepatitis C, particularly among intravenous drug users. Estimates of infection with the hepatitis C virus (HCV) in patients with severe mental illness in the USA have ranged from 8.5% to 19.6%. Alcohol use and misuse is the single biggest contributory factor to the development of fatal liver disease in people with hepatitis C. Neuropsychiatric symptoms are present in HCV infection, independent of any treatment. Despite such alarming observations, the success rate of antiviral treatment in chronic hepatitis C has improved considerably in recent years. This article explores psychiatrists' involvement in advocating for treatment inclusion, assessing patients' capacity to make treatment-related decisions and supporting the medical team in managing the complex journey a patient undertakes from being at high risk to receiving treatment for neuropsychiatric symptoms.

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Prevalence of Hepatitis C Among Psychiatric Patients in the Public Sector

Abstract: The prevalence of hepatitis C virus is high among psychiatric patients in the public sector. Much needs to be learned about the role of universal screening and effective techniques for primary prevention and antiviral treatment in this population.

Cited by 77 publications

References 7 publications

Seroepidemiology of hepatitis B virus infection among Chinese schizophrenia patients

Seroepidemiology of hepatitis B virus infection among Chinese schizophrenia patients

The neuropsychiatric aspect of the HCV infection

Hepatitis C: a patient's journey from a psychiatrist's perspective

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