Prevalence of hepatitis B virus infection among tuberculosis patients with or without HIV in Goiânia City, Brazil

Aires, Rodrigo Sebba; Matos, Marcos André de; Lopes, Carmen Luci Rodrigues; Teles, Sheila Araújo; Kozlowski, Aline Garcia; Silva, A.M.C.; Filho, Joao Araujo; Lago, B.V.; Mello, Francisco Campello do Amaral; Martins, Regina Maria Bringel

doi:10.1016/j.jcv.2012.04.006

Cited by 24 publications

(31 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In fact, the OBI prevalence (12.0%) found in this study was proportional to the HBV infection rate. Our results corroborate those for OBI prevalence among TB patients (14.4%) in another low HBV endemic area in Brazil …”

Section: Discussionsupporting

confidence: 90%

Occult hepatitis B virus infection: clinical implications in tuberculosis treatment

Trigo

Brasil

Costa

et al. 2016

Journal of Viral Hepatitis

View full text Add to dashboard Cite

Occult hepatitis B virus infection (OBI) is characterized by the absence of HBsAg and persistence of the virus genome (HBV-DNA) in liver tissue and/or blood. OBI has been reported in several clinical contexts. However, the clinical significance of OBI in tuberculosis (TB) treatment is unknown. We investigated the OBI prevalence and its impact on the risk of drug-induced liver injury (DILI) during TB treatment. This was a prospective cohort study with one hundred patients who were treated for TB from 2008 to 2015. Laboratory, clinical and demographic data of TB patients were extracted from medical records. Based on HBV-DNA testing of serum samples, an OBI prevalence of 12% was established; almost half of these patients had both anti-HBc and anti-HBs serological markers. Low CD4 cell counts have been shown to be a risk factor for OBI among TB patients co-infected with HIV (P=.036). High DILI incidence was observed in this study. A multivariable Cox proportional hazard model was conducted and identified OBI (HR 2.98, 95% CI 1.30-6.86) as the strongest predictor for DILI when adjusted to CD4 cell count (HR 0.38, 95% CI 0.17-0.90), ALT before TB treatment (HR 1.37, 95% CI 0.81-2.32) and TB extrapulmonary clinical form (HR 2.91, 95% CI 1.75-7.21). The main aim of this study was to highlight DILI as a clinical outcome during treatment of TB patients with OBI. Therefore, HBV-DNA testing should be considered routinely in monitoring DILI, and also in other clinical implications associated with OBI, reduce morbidity and mortality.

show abstract

Section: Discussionsupporting

confidence: 90%

Occult hepatitis B virus infection: clinical implications in tuberculosis treatment

Trigo

Brasil

Costa

et al. 2016

Journal of Viral Hepatitis

View full text Add to dashboard Cite

show abstract

“…Similar findings have been reported in different studies [2,4,5,11,[17][18][19][20][21][22]. Hepatitis B virus carrier might be at a higher risk of contracting TB.…”

Section: Ethical Approvalsupporting

confidence: 90%

Parallel and Overlapping Infection of Human Immunodeficiency Virus and Hepatitis B Virus Among Tuberculosis Patients Attending A Tuberculosis/Leprosy Referral Centre in Central Nigeria: A Cross-Sectional Study

Gri¹,

Oti²,

Ca³

2018

J Transl Gastroenterol Clin Hepatol

View full text Add to dashboard Cite

Tuberculosis (TB) is a global health problem. Coinfection with Human Immunodeficiency Virus (HIV) and Hepatitis B virus (HBV) among TB patients has paved way for the resurgence of Mycobacterium tuberculosis infection as well as increased risk of hepatotoxicity during tuberculosis therapy. There is paucity of published data on HIV/HBV infection in TB patients in Nigeria. This was a baseline study carried out to determine coinfection of HIV and HBV in Tuberculosis confirmed patients attending a TB/Leprosy referral healthcare Centre in Central Nigeria. Blood samples were collected from 400 confirmed TB patients and their sociodemograph information were obtained using a structured questionnaire. Samples were analyzed for anti-HIV and HbsAg using Enzyme Linked Immunosorbent Assay (J. Mitra and Co. Pvt. Ltd, India and Shantha Biotechnics Ltd, India respectively). Data were analyzed using SSP version 2.80. P value ≤ 0.05 was considered statistically significant. Of the 400 patients, 68(17.0%) tested positive for HIV and 48(12.0%) for HBV while 6 (1.5%) had HIV/HBV coinfection. Gender, history of STI, history of HBV vaccine and educational status were associated risk factors for the viral infection. Age, history of blood transfusion and scarification mark did not show any statistically significant association to the viral infections. The prevalence rates of HIV and HBV recorded in this population is a cause for alarm. There is therefore a need to introduce the monitoring of TB patients for therapyrelated hepatotoxicity and performance of these viral infections.

show abstract

“…The current study was the first in Brazil that investigated the occurrence of occult HBV infection in leprosy patients and identified occult infection in 5.3% of those tested. This frequency was lower than that reported in HIV/AIDS patients (approximately 14%) or in patients with tuberculosis (coinfected or not with HIV) in the same country. On the other hand, the rate of occult HBV infection found in leprosy patients (5.3%) was higher than that reported in healthy candidates for blood donation in Brazil .…”

Section: Discussioncontrasting

confidence: 74%

“…16,17 The prevalence of occult HBV infection is influenced by a number of factors, such as sensitivity of the technique used to detect the HBV DNA and epidemiological characteristics of the population, making it difficult to compare results of different studies. [18][19][20][21][22][23][24][25][26] The current study was the first in Brazil that investigated the occurrence of occult HBV infection in leprosy patients and identified occult infection in 5.3% of those tested. This frequency was lower than that reported in HIV/AIDS 19,20 patients (approximately 14%) or in patients with tuberculosis (coinfected or not with HIV) 24 in the same country.…”

Section: Discussionmentioning

confidence: 87%

“…Brazil is responsible for 13% of the new cases of leprosy in the world, but it is considered a country of “low” endemicity for HBV, with a prevalence of HBsAg estimated at 0.65% . The prevalence of occult HBV infection is influenced by a number of factors, such as sensitivity of the technique used to detect the HBV DNA and epidemiological characteristics of the population, making it difficult to compare results of different studies …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Occult hepatitis B virus infection in patients with leprosy

Costa

Morais

Gonçales

et al. 2018

Journal of Medical Virology

View full text Add to dashboard Cite

Leprosy patients may present with immune system impairment and have a higher hepatitis B virus (HBV) seroprevalence, justifying the investigation of occult HBV infection in these individuals. The aim of this study was to verify the frequency and the clinical factors associated with occult HBV infection in leprosy patients. Between 2015 and 2016, leprosy patients from a reference center in Brazil were interviewed to assess clinical data. Blood samples were collected for the screening of HBV serological markers using enzyme‐linked immunosorbent assay. Patients with negative hepatitis B surface antigen (HBsAg) that had positive anti‐HBc and/or anti‐HBs were selected for HBV DNA detection using real‐time polymerase chain reaction. SPSS was used for data analysis. Among 114 selected patients, six were identified with occult infection (5.3%) and five of them with multibacillary leprosy. Three patients with occult infection had a history of a type 2 reaction (P = 0.072; OR, 4.97; 95% CI, 0.87‐28.52). Only two patients with occult infection had isolated anti‐HBc, while three had isolated anti‐HBs, including those with the highest HBV DNA titers. In conclusion, in leprosy patients with negative HBsAg and positive anti‐HBc and/or anti‐HBs, occult HBV infection occurs in 5.3% and can be found even in patients with isolated anti‐HBs.

show abstract

Prevalence of hepatitis B virus infection among tuberculosis patients with or without HIV in Goiânia City, Brazil

Abstract: HBV infection was common, particularly among this with HIV infection.

Cited by 24 publications

References 26 publications

Occult hepatitis B virus infection: clinical implications in tuberculosis treatment

Occult hepatitis B virus infection: clinical implications in tuberculosis treatment

Parallel and Overlapping Infection of Human Immunodeficiency Virus and Hepatitis B Virus Among Tuberculosis Patients Attending A Tuberculosis/Leprosy Referral Centre in Central Nigeria: A Cross-Sectional Study

Occult hepatitis B virus infection in patients with leprosy

Contact Info

Product

Resources

About