Prevalence of hepatitis B and hepatitis C among diabetes mellitus type 2 individuals

Villar, Lívia Melo; Geloneze, Bruno; Vasques, Ana Carolina Junqueira; Pires, Maria Lúcia Elias; Miguel, Juliana Custódio; Silva, Elisangela Ferreira da; Marques, Vanessa Alves; Scalioni, Leticia de Paula; Lampe, Elisabeth

doi:10.1371/journal.pone.0211193

Cited by 17 publications

(23 citation statements)

References 29 publications

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“…They further showed that the viral load and antibody titers are positively correlated with blood glucose levels ( 241 ). Diabetic patients also have been shown to have an increased risk of infection with the severe acute respiratory syndrome coronavirus (SARS-CoV) ( 242 ), Middle East respiratory syndrome coronavirus (MERS-CoV) ( 243 ), SARS coronavirus 2 (SARS-CoV-2) ( 21 , 22 ), hepatitis C virus (HCV) ( 244 – 246 ), and West Nile virus encephalitis (WNVE) ( 247 ).…”

Section: Effects Of T2dm On the Susceptibility Of Patients To Infectimentioning

confidence: 99%

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

et al. 2020

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Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM). The field of immunometabolism implies a bidirectional link between the immune system and metabolism, in which inflammation plays an essential role in the promotion of metabolic abnormalities (e.g., obesity and T2DM), and metabolic factors, in turn, regulate immune cell functions. Obesity as the main inducer of a systemic low-level inflammation is a main susceptibility factor for T2DM. Obesity-related immune cell infiltration, inflammation, and increased oxidative stress promote metabolic impairments in the insulin-sensitive tissues and finally, insulin resistance, organ failure, and premature aging occur. Hyperglycemia and the subsequent inflammation are the main causes of micro-and macroangiopathies in the circulatory system. They also promote the gut microbiota dysbiosis, increased intestinal permeability, and fatty liver disease. The impaired immune system together with metabolic imbalance also increases the susceptibility of patients to several pathogenic agents such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus, the need for a proper immunization protocol among such patients is granted. The focus of the current review is to explore metabolic and immunological abnormalities affecting several organs of T2DM patients and explain the mechanisms, whereby diabetic patients become more susceptible to infectious diseases.

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Section: Effects Of T2dm On the Susceptibility Of Patients To Infectimentioning

confidence: 99%

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

et al. 2020

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“…Based on previous reports, it is important to keep in mind, if on the one hand insulin resistance is recognized as a risk factor for the progression of HCV-related liver disease[ 26 - 29 , 31 , 32 ], on the other hand, preceding HCV infection significantly increases the risk of developing type 2 diabetes mellitus[ 7 ]. Additionally, diabetic patients are at an increased risk of acquiring HCV infection[ 64 - 66 ]. Thus, this two-way interface, i.e ., the relationship linking HCV and type 2 diabetes mellitus, is possibly determined by complex and multifaceted interactions among the hepatitis virus, the environment and the host.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus

Silva

Vieira

Melo

et al. 2020

WJH

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BACKGROUND Chronic hepatitis C (CHC) is associated with type 2 diabetes mellitus. Although the pathogenesis remains to be elucidated, a growing evidence has suggested a role of pro-inflammatory immune response. Increased serum concentrations of Interleukin 6 (IL-6) have been associated with insulin resistance, type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection. AIM To investigate the frequency of IL-6-174G/C (rs1800795) single nucleotide polymorphism (SNP) in CHC patients and in healthy subjects of the same ethnicity. Associations between type 2 diabetes mellitus (dependent variable) and demographic, clinical, nutritional, virological and, IL-6 genotyping data were also investigated in CHC patients. METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects (blood donors) were prospectively included. Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association. Clinical, biochemical, histological and radiological methods were used for the diagnosis of the liver disease. IL-6 polymorphism was evaluated by Taqman SNP genotyping assay. The data were analysed by logistic regression models. RESULTS Type 2 diabetes mellitus, blood hypertension and liver cirrhosis were observed in 20.8% (51/245), 40.0% (98/245) and 38.4% (94/245) of the patients, respectively. The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls ( P = 0.81) and all alleles were in Hardy-Weinberg equilibrium ( P = 0.38). In the multivariate analysis, type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174 (OR = 0.42; 95%CI = 0.22-0.78; P = 0.006) and positively associated with blood hypertension (OR = 5.56; 95%CI = 2.79-11.09; P < 0.001). CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus. The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations.

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“…However, there are studies reporting that diabetes is not associated with hepatitis. A study from Brazil reported that low prevalence of HBV and high prevalence of hepatitis C virus (HCV) among T2DM patients (Villar et al, 2019). Huang et al conducted a cross-sectional study about the association between HBV, HCV and T2DM prevalence among 9,932 participants in an endemic area for HBV and HCV infections in Taiwan.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Association between Hepatitis B Virus Infection and Type 2 Diabetes Mellitus

2019

JSTR

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It was aimed to evaluate the relationship between diabetes and hepatitis B in patients with type 2 diabetes. This retrospective study was conducted between January 2012 and December 2017 in Dicle University Hospital. A total of 686 patients (344 male, 342 female) diagnosed with Type 2 Diabetes Mellitus (T2DM) (whose with HbA1c>6.5) were included. Alcohol users, patients who underwent dialysis and with frequent blood transfusions (such as thalassemia major or hemophilia) were excluded from the study. Patients were divided into two groups as those with hepatitis B (HBsAg >1) and those without hepatitis B (HBsAg <1). Age, gender and liver function tests of the patients were evaluated retrospectively and compared between the two groups. Pearson correlation coefficient was calculated between the variables. Student's t test was used to compare the two groups. Chi-square test was used for categorical variables. In the HBsAg positive patient group; the relationship of HbsAg with Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) was significant (p <0.05), also a statistically significant relationship was found between Hba1c elevation with ALT levels and age (p<0.01). No statistically significant difference was found between HBsAg and HbA1c in HB patients group. There was no significant difference in AST and ALT levels between two groups. Conclusion: There was no significant relationship between HB and T2DM in current retrospective study including T2DM patients.

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Prevalence of hepatitis B and hepatitis C among diabetes mellitus type 2 individuals

Cited by 17 publications

References 29 publications

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus

Investigation of Association between Hepatitis B Virus Infection and Type 2 Diabetes Mellitus

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