Prevalence of hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E virus as causes of acute viral hepatitis in North India: A hospital based study

Jain, Parul; Prakash, Shantanu; Gupta, Siddharth; Singh, K. P.; Shrivastava, Shakti Saumnam; Singh, D. D.; Singh, Jitendra; Jain, Amita

doi:10.4103/0255-0857.115631

Cited by 79 publications

(82 citation statements)

References 14 publications

(17 reference statements)

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“…Hepatitis A virus was the commonest aetiological agent followed by Hepatitis E virus. Similar results have been documented in previous studies from India [1,2]. All the patients of acute hepatitis were icteric and had high coloured urine.…”

Section: Discussionsupporting

confidence: 91%

“…The other common symptoms were anorexia, nausea and vomiting, hepatomegaly and fever. A previous study from India also has shown similar results with jaundice being the commonest symptom [1].…”

Section: Discussionsupporting

confidence: 72%

“…Acute viral hepatitis (AVH) continues to be a major public health burden in developing countries like India [1]. Studies have previously documented a variable prevalence of hepatotropic viruses: Hepatitis A Virus (HAV) (1.7-67%), Hepatitis B Virus (HBV) (7.3-42%), Hepatitis C Virus (HCV) (1.16-10.6%) and HEV (Hepatitis E Virus) (16.3-66.3%) [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Lipid profile in acute viral hepatitis: A study from north eastern India

Bhattacharya¹,

Tomke²,

Saikia³

2016

Int J of Biomed & Adv Res

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Background: Acute viral hepatitis is associated with significant hepatic dysfunction including lipid metabolism. Variations in the serum lipid fractions in acute viral hepatitis due to hepatic injury may serve as prognostic marker for severity of hepat ic injury. Methods: Hospital-based prospective study on acute viral hepatitis. Fifty cases of acute viral hepatitis and 50 age and sex matched controls, (>18 years) were studied. Routine biochemical investigation, hepatotropic viral serology and fasting serum lipid fractions were analysed for changes in patients with acute viral hepatitis. Chi-square test was used for comparing variables. A 'p value' <0.05 was considered statistically significant. Results: Baseline parameters were similar between cases and controls (p>0.05). Jaundice (100%) and high coloured urine (100%) were the commonest presentations. Hepatitis A virus (52%) and Hepatitis E virus (30%) were commonest aetiological agents. Serum cholesterol, triglycerides, low density lipoprotein (LDL) were significantly higher (p<0.01) while high density lipoprotein (HDL) was significantly lower (p<0.01) in acute viral hepatitis compared to controls. There was no statistically significant difference in the levels of very LDL between cases and controls (p>0.05). Complications were seen in 7 (14%) cases with hepatic encephalopathy being the commonest (6%). Serum cholesterol, triglycerides, LDL were significantly higher and HDL was significantly lower in hepatitis with complications compared to uncomplicated hepatitis (p<0.01). Conclusion Acute viral hepatitis leads to significant alterations of serum lipid fractions which may serve as an indicator of severity of liver damage and be helpful in assessing the prognosis of patients with acute viral hepatitis.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lipid profile in acute viral hepatitis: A study from north eastern India

Bhattacharya¹,

Tomke²,

Saikia³

2016

Int J of Biomed & Adv Res

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show abstract

“…An indication towards epidemiological shift of AVH from children (34) to adults with (212) male preponderance was seen. Similar observations were made by P. Jain et al [20] During the last 50 years a large number of physicians have treated and described dengue disease in India. [21] 131 laboratory (IgM-ELISA) confirmed cases of dengue fever were treated at Sir Ronald Ross Institute of Tropical & Communicable Diseases (SRRIT&CD) from August 2012 to September 2013.…”

Section: Discussionsupporting

confidence: 80%

An Epidemiology Based Inpatient Data Analysis at an Infectious Disease Hospital

Rao¹,

Rani²,

Taruni³

et al. 2015

jemds

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“…Chadha et al from Pune reported HBV as a cause for 5.4% of acute viral hepatitis cases ; similarly in studies from New Delhi in 1984 and 2002 the rates were 9% and 7.6% respectively; also from Lucknow, the rate was 9.79%. 3,[6][7][8] Study done from Hong Kong showed incidence of HBV to be 8% of all acute viral hepatitis in children less than 12 years. 9 From Kathmandu, Nepal HBV was responsible for 5% of causes of acute hepatitis in children under 15 years of age.…”

Section: Discussionmentioning

confidence: 99%