Prevalence of hemorrhagic fever with renal syndrome in Qingdao City, China, 2010–2014

Jiang, Fachun; Zhang, Zhentang; Dong, Lei; Hao, Baocheng; Xue, Zaifeng; Ma, Dongqiang; Wen, Hong Ling; Yu, Hao; Yu, Xue Jie

doi:10.1038/srep36081

Cited by 19 publications

(22 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously, in the rural population of two prefecture-level cities (Zibo and Qingdao) of China, we found HFRS had a high incidence rate which ranged from 1.96 cases/100,000 persons to 28.9/100,000 in different years [10,11]. These studies indicated HFRS was epidemic in these areas.…”

Section: Introductionmentioning

confidence: 78%

“…These studies indicated HFRS was epidemic in these areas. Peridomestic rodents were also captured for orthohantavirus detection in the two cities and orthohantavirus antigens were found by immunofluorescence assay in 5.2% (29/559) and 3.8% (9/240) of these rodents, respectively [10,11], and the seropositive rate to hantavirus of host animals was as high as 23.3% [12]. Hantaan orthohantavirus (HTNV) and Seoul orthohantavirus (SEOV) are the causative agents of HFRS in these areas.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Suggestive Serological Evidence of Infection with Shrew-Borne Imjin Virus (Hantaviridae) in Humans

Sun

Qin

et al. 2019

Viruses

Self Cite

View full text Add to dashboard Cite

The pathogenicity of the shrew-borne Imjin virus (MJNV) is unknown. The objective of our study was to find serological evidence of MJNV infection in humans. Partial MJNV nucleocapsid protein (NP) was cloned and expressed as an antigen for double-antigen sandwich ELISA, IgM capture ELISA, and dot blot to detect MJNV specific antibodies in hemorrhagic fever with renal syndrome (HFRS) patients’ and healthy persons’ sera from endemic areas in China. The purified recombinant NP reacted with neither the 90 healthy individuals’ sera from non-endemic areas of MJNV nor the 100 antisera to HFRS-causing virus, indicating that the MJNV NP had no cross-reaction with normal human sera and HFRS-causing viral antibodies. As determined by screening ELISA and dot blot analysis, IgG antibodies against MJNV NP were detected in sera from two of 385 healthy individuals from MJNV-endemic areas, suggesting infection with MJNV or MJNV-like thottimvirus. Based on the suggestive evidence, healthcare workers should be alert to febrile diseases occurring among individuals with exposure to shrew-infested habitats.

show abstract

Section: Introductionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Suggestive Serological Evidence of Infection with Shrew-Borne Imjin Virus (Hantaviridae) in Humans

Sun

Qin

et al. 2019

Viruses

Self Cite

View full text Add to dashboard Cite

show abstract

“…Some studies showed that the orthohantavirus seroprevalence in Asian countries, for example China, Korea, Thailand and Singapore prevailed between 0.5% and 33.3%, and in European countries between 0% and 24%. (Bi et al, ; Mertens et al, ; Jiang, Zhang, et al, ; Xiao et al, ; Zou, Chen, & Sun, 2016).…”

Section: Discussionmentioning

confidence: 99%

Serological investigation of orthohantaviruses in patients with fever of unknown origin in Kazakhstan

Tukhanova¹,

Shin²,

Abdiyeva³

et al. 2020

Zoonoses and Public Health

View full text Add to dashboard Cite

Objective: Orthohantaviruses are geographically widely distributed and present various clinical manifestations from mild symptoms to the severe form of haemorrhagic fever with renal syndrome (HFRS) in Eurasia. Official registration of HFRS in Kazakhstan started in the year 2000. However, the true prevalence of human infections by orthohantaviruses within Kazakhstan is unknown. The aim of this study was to investigate of the seroprevalence of orthohantavirus infections in patients with fever of unknown origin (FUO) in two regions, Almaty and Kyzylorda region. Methods: Paired serum samples from 802 patients with FUO were screened for the presence of orthohantavirus IgG and IgM antibodies by ELISA. Positive samples were further tested by immunoblotting and indirect immunofluorescence tests (IIFT) to determine the respective orthohantavirus serotypes. Suspected acute serum samples were additionally checked by a RT-PCR to identify viral RNA. Results: In total 178/802 (22.2%) serum samples reacted with orthohantavirus IgG antibodies and 4/802 (0.5%) with IgM antibodies. All positive samples were tested by immunoblotting which resulted in 2.9% positive samples with IgG antibodies against Puumala (PUUV), Hantaan (HTNV) and Dobrava (DOBV) virus serotypes in Almaty region and 5.4% to PUUV and DOBV serotypes in Kyzylorda region, respectively.In the IFFT, 1.9% positive samples from Almaty and 3.1% from Kyzylorda were confirmed for PUUV and DOBV serotypes. Out of four IgM ELISA positive samples only three were positive against PUUV in the immunoblot and showed weak positive reactivity for the Saaremaa (SAAV), PUUV and HTNV serotypes in the IFFT. Conclusions:This study demonstrates the presence of orthohantavirus infections among patients with FUO in Kazakh regions that were so far considered as nonendemic. The healthcare system needs to be prepared accordingly in order to be capable of detecting cases and providing adequate management of patients.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

show abstract

“…Positive Hantavirus found in R. norvegicus in the study site is higher than the number found in other studies performed in some countries in the world. The prevalence rate of hantavirus infection in R. norvegicus was reported in between 6.3% to 17.8% [11][12][13]. However, the result of study in Indonesia revealed various results.…”

Section: Discussionmentioning

confidence: 99%

Hantavirus Infection on Rats in the Leptospirosis Increased Case Area in Tangerang Regency

Mulyono¹,

Pujiyanti²,

Ristiyanto³

et al. 2020

Proceedings of the 5th Universitas Ahmad Dahlan Public Health Conference (UPHEC 2019)

View full text Add to dashboard Cite

Hantavirus infection and leptospirosis are a serious zoonotic disease that spread across the globe. They have similar clinical manifestations, in which the rat is the main reservoir of them. The aim of the study was to identify the percentage of Hantavirus infection and co-infection of Hantavirus and Lepstospira in the rats in an area where increasing cases of leptospirosis occurred. This study was conducted in Tangerang Regency, Banten Province on October to November in 2016. The identification of the trapped rats and the samples were examined by using an immunology test (Elisa) and a molecular test (PCR) to find out the result of Leptospira and Hantavirus infection. A total of 52 rats were caught in the study. They consisted of 2 species (Rattus norvegicus and Rattus tanezumi). Hantavirus infections were found in 8 of the 48 rats while coinfection (Hantavirus and Leptospira) were found in 6 of the 48 rats. 16.7% of the rats were positively infected by Hantavirus. Meanwhile, the total co-infections with both Hantaviruses and Leptospira were 12.5%. Cautions should be given if R. norvegicus and R. tanezumi were found in one residential area.

show abstract

Prevalence of hemorrhagic fever with renal syndrome in Qingdao City, China, 2010–2014

Cited by 19 publications

References 9 publications

Suggestive Serological Evidence of Infection with Shrew-Borne Imjin Virus (Hantaviridae) in Humans

Suggestive Serological Evidence of Infection with Shrew-Borne Imjin Virus (Hantaviridae) in Humans

Serological investigation of orthohantaviruses in patients with fever of unknown origin in Kazakhstan

Hantavirus Infection on Rats in the Leptospirosis Increased Case Area in Tangerang Regency

Contact Info

Product

Resources

About