Prevalence of hemoglobin S trait among blood donors: a cross-sectional study

Antwi‐Baffour, Samuel; Asare, Ransford Owiredu; Adjei, Jonathan Kofi; Kyeremeh, Ransford; Adjei, David Nana

doi:10.1186/s13104-015-1583-0

Cited by 25 publications

(36 citation statements)

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“…This mutation consequently changes the physico-chemical properties of the haemoglobin molecule [12]. A person who inherits haemoglobin S from one parent and haemoglobin A (normal gene) from the other has a sickle cell trait (SCT) or is said to be a carrier of sickle cell disease [13]. The prevalence of sickle cell trait (SCT) is highest in Africans and people of African descent.…”

Section: Introductionmentioning

confidence: 99%

Storage related haematological and biochemical changes in Plasmodium falciparum infected and sickle cell trait donor blood

et al. 2018

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BackgroundIn sub-Saharan Africa where sickle cell trait (SCT) and malaria is prevalent, significant proportions of blood donors may be affected by one or more of these abnormalities. The haemato-biochemical properties of SCT and asymptomatic malaria in donor blood have not been evaluated. This study evaluated the haemato-biochemical impact of SCT and asymptomatic malaria infections in citrate-phosphate-dextrose-adenine (CPDA-1) stored donor blood units.MethodsFifty-milliliters of sterile CPDA-1 anti-coagulated blood were drained into the sample pouch attached to the main blood bag. Ten units each of sickle cell/malaria negative, sickle cell and malaria positive blood were analyzed. Baseline and weekly haematological profiling and week 1, 3 and 5 concentrations of plasma haemoglobin, % haemolysis, sodium, potassium and chloride and lactate dehydrogenase (LDH) were assayed. Differences between baseline and weekly data were determined using one-way analysis of variance (ANOVA) and Kruskal-Wallis test, whereas differences between baseline parameters and week 1–3 data pairs were determined using paired t-test. P-value < 0.05 was considered statistically significant.ResultsStorage of SCT and malaria infected blood affected all haematological cell lines. In the SCT donors, red blood cells (RBC) (4.75 × 1012/L ± 1.43baseline to 3.49 × 1012/L ± 1.09week-5), haemoglobin (14.45 g/dl ± 1.63baseline to 11.43 g/dl ± 1.69week-5) and haematocrit (39.96% ± 3.18baseline to 33.22% ± 4.12week-5) were reduced. In the asymptomatic malaria group, reductions were observed in RBC (5.00 × 1012/L ± 0.75baseline to 3.72 × 1012/L ± 0.71week-5), haemoglobin (14.73 g/dl ± 1.67baseline to 11.53 g/dl ± 1.62week-5), haematocrit (42.72% ± 5.16baseline to 33.38% ± 5.80week-5), mean cell haemoglobin concentration (35.48 g/dl ± 1.84baseline to 35.01 g/dl ± 0.64week-5) and red cell distribution width coefficient of variation (14.81% ± 1.54baseline to 16.26% ± 1.37week-5). Biochemically, whereas plasma LDH levels significantly increased in asymptomatic malaria blood donors (319% increase at week 5 compared to baseline), SCT blood donors had the most significant increase in plasma potassium levels at week 5 (382% increase). Sodium ions significantly reduced in SCT/malaria negative and sickle cell trait blood at an average rate of 0.21 mmol/L per day. Moreover, elevations in lymphocytes-to-eosinophils and lymphocytes-to-neutrophils ratios were associated with SCT and malaria positive blood whilst elevation lymphocytes-to-basophils ratio was exclusive to malaria positive blood.ConclusionSevere storage lesions were significant in SCT or malaria positive donor blood units. Proper clinical evaluation must be done in prospective blood donors to ensure deferral of such donors.Electronic supplementary materialThe online version of this article (10.1186/s12878-018-0128-x) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Storage related haematological and biochemical changes in Plasmodium falciparum infected and sickle cell trait donor blood

et al. 2018

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“…Nigeria probably has the highest number of people with the trait, not just because of its high population but also because of a high prevalence of 25-30% [9] . The distributions in other parts of Africa are between 10-15% for Liberia, Ghana and Uganda [10][11][12] , respectively, Cameroon and the Republic of Gabon, a central African country, have a prevalence of 19 and 22%, respectively, closer to the prevalence in Nigeria than to other African countries [13,14] . Review of data from two decades of newborn screening in the United States revealed a prevalence of 1.5% [15] , but the prevalence in African Americans is about 8% [16] , which is similar to that of other African populations who migrated out of Africa as a result of the slave trade.…”

Section: Epidemiologymentioning

confidence: 97%

Sickle Cell Trait: A Benign State?

Kotila

2016

Acta Haematol

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Background: Sickle cell trait (SCT) is the heterozygous form of sickle cell disease and expectedly should be a benign state with no complications ascribed to it. There are numerous reports challenging its being a benign condition, though this is controversial. Methods and Results: A review of the results of the accompanying investigations done on some of the patients show that beta thalassemia may be responsible for many of the ascribed symptoms and complications. These patients may therefore have sickle cell beta thalassemia, a compound heterozygous form of sickle cell disease. Conclusion: It is important to screen for beta thalassemia using red cell indices and quantitation of the different hemoglobin fractions before attributing any symptoms to SCT. DNA analysis, though useful in ascertaining the presence of the sickle cell gene, is not sufficient. There is the need to exclude the presence of mutations for beta thalassemia, which often is geographical region-specific.

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“…Em Gana, país da África ocidental, uma pesquisa realizada em um banco de sangue, mostrou que, entre 150 doadores, 17 (11,3%) eram portadores do traço falcêmico. Desses, somente 4 (2,7%) tinham conhecimento da sua condição 18 . Já, na Alemanha, um estudo realizado com dados de 37.838 recém-nascidos, evidenciou que apenas 0,2% deles eram portadores do traço falcêmico 19 .…”

Section: Cançado E Jesusunclassified

“…Situação semelhante ocorre em Gana, onde se encontrou uma proporção de 12 homens para cada mulher doadora de sangue. Esse predomínio do sexo masculino na doação de sangue pode ser justificado por algumas condições fisiológicas femininas, tais como gravidez, lactação e menstruação, que têm restrição na doação de sangue 18 . O presente estudo traz algumas limitações, entre elas destaca-se a ausência de etnia nos dados dos doadores.…”

Section: Cançado E Jesusunclassified