Prevalence of Helicobacter pylori vacA , cagA , cagE , oipA, iceA , babA2 and babB genotypes in Iranian dyspeptic patients

Dabiri, Hossein; Jafari, Fatemeh; Baghaei, Kaveh; Shokrzadeh, Leila; Abdi, Saeed; Pourhoseingholi, Mohamad Amin; Mohammadzadeh, Alireza

doi:10.1016/j.micpath.2017.02.018

Cited by 41 publications

(24 citation statements)

References 42 publications

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“…Furthermore, high incidence of these genotypes has been reported in the H. pylori strains isolated from different types of food samples (Esmaeiligoudarzi et al, ; Ghorbani et al, ; Gilani, Razavilar, Rokni, & Rahimi, ; Khaji et al, ; Mousavi et al, ; Ranjbar et al, 2016a, 2016b; Saeidi & Sheikhshahrokh, ; Talaei et al, ; Talimkhani & Mashak, ; Yahaghi et al, ). Adjacent association of vacA , cagA , and iceA genotypes of H. pylori bacteria with secretion of interleukin‐8 and cytotoxin, adhesion to gastric epithelial cells, occurrence of inflammatory effect, vacuolization, apoptosis procedure in gastric epithelial cells, peptic ulceration, increase acute neutrophilic infiltration, interleukin‐10 secretion and inflammation, has been presented previously (Dabiri et al, ; Podzorski et al, ; Torkan & Shahreza, ). As H. pylori isolates in our investigation harbored vacA , cagA , and iceA genotypes, consumption of traditional dairy product samples contaminated with virulent strains of H. pylori may aggravate duodenal ulceration, gastric mucosal atrophy, and gastric cancer.…”

Section: Resultssupporting

confidence: 57%

“…We also found that vacA s1a , s2 , m1a and m2 , cagA and iceA1 alleles, s1am1a , s2m1a , s1am2 , and s2m2 genotyping patterns were the most routinely identified virulence characters of H. pylori strain isolated from traditional dairy product samples. High incidence of vacA , cagA , and iceA1 genotypes was also reported in the H. pylori strains isolated from clinical samples of human and animal species (Dabiri et al, ; Momtaz, Dabiri, Souod, & Gholami, ; Podzorski, Podzorski, Wuerth, & Tolia, ; Torkan & Shahreza, ). Furthermore, high incidence of these genotypes has been reported in the H. pylori strains isolated from different types of food samples (Esmaeiligoudarzi et al, ; Ghorbani et al, ; Gilani, Razavilar, Rokni, & Rahimi, ; Khaji et al, ; Mousavi et al, ; Ranjbar et al, 2016a, 2016b; Saeidi & Sheikhshahrokh, ; Talaei et al, ; Talimkhani & Mashak, ; Yahaghi et al, ).…”

Section: Resultsmentioning

confidence: 71%

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Antimicrobial resistance and genotyping of vacA, cagA, and iceA alleles of the Helicobacter pylori strains isolated from traditional dairy products

Ranjbar

Farsani

Dehkordi

2018

Journal of Food Safety

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Dairy products play a considerable role in transmission of Helicobacter pylori. The current study was done to assess phenotypic characters of antimicrobial resistance and genotyping pattern of vacA, cagA, and iceA alleles among the H. pylori strains isolated from dairy products. Eight‐hundred dairy samples were collected and cultured. Antimicrobial resistance and genotyping patterns were assessed using disk diffusion and polymerase chain reaction, respectively. Thirty‐one out of 800 (3.87%) traditional dairy product samples were positive for H. pylori. Cheese (11.53%) samples had the highest incidence of H. pylori, while yoghurt (1.11%) had the lowest. Helicobacter pylori strains harbored the highest incidence of resistance against ampicillin (93.54%), amoxicillin (93.54%), tetracycline (90.32%), erythromycin (80.64%), and metronidazole (77.41%). VacA s1a (90.32%), m1a (90.32%), s2 (80.64%) and m2 (77.19%), cagA (51.61%), and iceA1 (32.25%) were the most routinely identified genotypes. S1am1a (67.74%), s2m1a (64.51%), and s1am2 (51.61%) were the most routinely identified genotyping pattern. Simultaneous presence of vacA, cagA, and iceA genotypes in antimicrobial resistant H. pylori strains indicates important public health issue regarding the consumption of dairy products. However, additional researches are required to find molecular genetic homology and other epidemiological aspects of H. pylori in dairy products. Practical applications Due to the high consumption rate of dairy samples, they should have a high microbial quality. Foods with animal origins and especially dairy samples are considered as a probable source of Helicobacter pylori infections. The incidence of contamination of dairy samples by H. pylori is fairly high, and nearly all of the isolates exhibited resistance against several types of antimicrobials and harbored pathogenic vacA, cagA, and iceA genotypes, so the risk of probable foodborne diseases caused by H. pylori in such products should not be neglected. Additionally, dairy samples may act as a reservoir of H. pylori with ability to transfer antimicrobial resistance and virulent genotypes.

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Section: Resultssupporting

confidence: 57%

Section: Resultsmentioning

confidence: 71%

Antimicrobial resistance and genotyping of vacA, cagA, and iceA alleles of the Helicobacter pylori strains isolated from traditional dairy products

Ranjbar

Farsani

Dehkordi

2018

Journal of Food Safety

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“…The H. pylori IgG antibody positivity was 72.8%; no change in the seroprevalence was observed during the study period. In the same country, Dabiri et al studied H. pylori genotype prevalence in 160 dyspeptic H. pylori positive patients; vac A, cag A, cag E, oip A, ice A1, bab A2 and bab B genes were positive in 100%, 69%, 51%, 55%, 26%,78% and 28% of 160 strains, respectively. The presence of bab B and ice A1 significantly correlated with a higher risk of gastric cancer (GC) development.…”

Section: Global Prevalence Of Helicobacter Pylori Infectionmentioning

confidence: 99%

Epidemiology of Helicobacter pylori infection

et al. 2018

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This review provides the most recent data concerning the epidemiology of Helicobacter pylori infection. Overall, the trend of declining prevalence of H. pylori infection is continuing, with major evidence available from studies in Europe. However, in some parts of the world, for example, in some countries in the Middle East, the prevalence has remained relatively stable. A number of systematic reviews and meta-analyses have been published during the past year indicating the lowest prevalence rates of the infection in Oceania (24.4%), the highest in Africa (79.1%), and the global annual recurrence rate of H. pylori (4.3%). The recurrence rates were found to be directly related to the human development index and prevalence of infection. Several studies have addressed the correlation between H. pylori infection and sociodemographic conditions, source of drinking water and dietary factors. A hypothesis on the role of insects and yeasts in transmitting H. pylori has been suggested and addressed. Helicobacter sp. have been found in flow flies in Brazil. So far there is no evidence available that H. pylori may survive and persist on the outer body of the fly.

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“…Dabiri et al . in 160 H. pylori isolated from Tehran patients, Iran, detected cag A, cag E, oip A, ice A1, bab A2, and bab B in 69%, 51%, 55%, 26%, 78%, and 28%.…”

Section: Prevalence Of Virulence Factors and Associations With Clinicmentioning

confidence: 99%

“…They are difficult to detect but should impact the effectiveness of eradication treatment. Multiple infections are very often suspected when virulence genes are characterized . Three articles focused on multiple infections this year.…”

Section: Multiple and Mixed H Pylori Infectionsmentioning

confidence: 99%

Epidemiology of Helicobacter pylori infection

2017

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The study of Helicobacter pylori genetic variability brought us interesting data on the history of mankind. Based on multilocus sequence typing and more recently on whole-genome sequencing, paleomicrobiology still attracts the attention of global researchers in relation to its ancestor roots and coexistence with humans. Three studies determining the prevalence of virulence factors illustrates the controversial results obtained since 30 years by studies trying to associate prevalence of different virulence markers and clinical outcomes of H. pylori infection. Three articles analyzed the prevalence and risk of multiple (genetically distinct isolates) and mixed (susceptible and resistant isolates) infections. A number of studies confirm that H. pylori prevalence is falling worldwide especially in the developed world and in children but that the level of infection is higher in certain ethnic minorities and in Migrants. There is little new in identifying the mode of H. pylori transmission though intrafamilial spread appears to be important. There have, however, been some interesting papers on the presence of the organism in food, water, and the oral cavity.

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Prevalence of Helicobacter pylori vacA , cagA , cagE , oipA, iceA , babA2 and babB genotypes in Iranian dyspeptic patients

Cited by 41 publications

References 42 publications

Antimicrobial resistance and genotyping of vacA, cagA, and iceA alleles of the Helicobacter pylori strains isolated from traditional dairy products

Antimicrobial resistance and genotyping of vacA, cagA, and iceA alleles of the Helicobacter pylori strains isolated from traditional dairy products

Epidemiology of Helicobacter pylori infection

Epidemiology of Helicobacter pylori infection

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