Prevalence of Helicobacter pylori infection in patients with precancerous changes and gastric cancer

Farinati, Fabio; Valiante, F.; Germanà, B.; Libera, G Della; Baffa, Raffaele; Rugge, Massimo; Plebani, Mario; Vianello, Fábio; Mario, F. Di; Naccarato, R.

doi:10.1097/00008469-199307000-00006

Cited by 45 publications

(26 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Secondly, because the data of H. pylori infection was not available among cases, it is difficult for us to adjust the potential confounding bias from H. pylori infection. However, it is difficult to measure H. pylori infection in gastric cancer patients because the loss of H. pylori from the stomach and reduced immune response occurs during gastric carcinogenesis (Karnes et al, 1991;Farinati et al, 1993). Thus, a prospective study should be further conducted for concomitant analysis of the genetic susceptibility and exposure to H. pylori.…”

Section: Discussionmentioning

confidence: 99%

Lack of Association of Common Polymorphisms in MUC1 Gene with H. pylori Infection and Non-cardia Gastric Cancer Risk in a Chinese Population

Zhang

Hao²,

Gao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Several lines of evidence support the notion that MUC1 is often aberrantly expressed in gastric cancer, and it is a ligand for Helicobacter pylori. Genetic variation in MUC1 gene may confer susceptibility to H. pylori infection and gastric cancer. We assessed the association of common polymorphisms in MUC1 gene with H. pylori infection and non-cardia gastric cancer using an LD-based tag SNP approach in north-western Chinese Han population. A total of four SNPs were successfully genotyped among 288 patients with non-cardia gastric cancer and 281 age-and sex-matched controls. None of the tested SNPs was associated with H. pylori infection. SNP rs9426886 was associated with a decreased risk of non-cardia gastric cancer, but lost significance after adjustment for multiple testing. Overall, our data indicated that common genetic variations in MUC1 gene might not make a major contribution to the risk of H. pylori infection and non-cardia gastric cancer in our studied population.

show abstract

Section: Discussionmentioning

confidence: 99%

Lack of Association of Common Polymorphisms in MUC1 Gene with H. pylori Infection and Non-cardia Gastric Cancer Risk in a Chinese Population

Zhang

Hao²,

Gao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…[62][63][64] Loss of H. pylori antibodies is particularly relevant in the gastric cancer cases, where extensive gastric atrophy, a precursor of gastric cancer, may lead to a declining prevalence of active infection as the progressively damaged gastric mucosa becomes a less supportive environment for H. pylori. [65][66][67] It is possible that this process may also contribute to an underestimation of an original CagA positive infection, but that this underestimate is smaller due to longer persistence of CagA antibodies. In such a case, the associations that we detected may be conservative.…”

Section: Discussionmentioning

confidence: 99%

Gastric cancer risk in a Mexican population: Role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin‐1 and ‐10 genes

Sicinschi

López‐Carrillo

Camargo

et al. 2005

Intl Journal of Cancer

View full text Add to dashboard Cite

Several polymorphisms of the IL1B and IL10 gene promoters have been reported to be associated with gastric cancer risk in Caucasians. However, studies in other populations have shown differing results. We aimed to test for associations between polymorphisms in IL1B (-31 and +3954), IL10-592 and IL1RN variable number of tandem repeats (VNTR) and risk of gastric cancer in a Mexican population. DNA was extracted from sera of 183 gastric adenocarcinoma patients and 377 controls. The IL1B-31, IL1B+3954 and IL10-592 biallelic polymorphisms were discriminated using 5' Nuclease (TaqMan) assays and Pyrosequencing. The IL1RN penta-allelic VNTR polymorphism was genotyped using PCR followed by GeneScan analysis. A significant interaction was found between IL1B-31 and CagA status for the risk of intestinal-type gastric cancer (p = 0.023). Among CagA positive subjects, those with IL1B-31CC genotype had an increased risk of intestinal-type gastric cancer (OR 3.19, 95%CI = 1.05-9.68), compared to carriers of IL1B-31TT genotype. In contrast, among CagA negative subjects, no significant association of IL1B-31CC genotype with gastric cancer was observed. The IL10-592CC genotype was associated with more than doubling of the risk of the intestinal-type gastric cancer (OR, 2.20, 95%CI = 1.04-4.65). A nonsignificantly increased risk for intestinal-type gastric cancer was found in IL1RN*2 carriers (OR 1.49, 95%CI = 0.89-2.50). None of these polymorphisms was significantly related to the risk of diffuse-type gastric cancer. No significant association was found between risk of gastric cancer and the IL1B+3954 polymorphism. Individuals carrying 2 or more of the risk-associated alleles (IL1B-31C, IL1RN *2 and IL10-592C) were at increased risk for intestinal-type gastric cancer, compared to those with 0 or 1 risk-associated allele. The risk from multiple risk-associated alleles was especially high in subjects infected with CagA positive H. pylori. Our results support the identification of the IL1B-31 promoter polymorphism as a useful marker for risk of intestinal type gastric cancer in persons with CagA positive H. pylori infections.

show abstract

“…Third, H. pylori infection is a wellknown cause of non-cardia gastric cancer and has been suggested to influence the expression of MUC5AC (Kocer et al, 2004). However, it is difficult to measure H. pylori infection in gastric cancer patients because the loss of H. pylori from the stomach and reduced immune response occurs during gastric carcinogenesis (Karnes et al, 1991;Farinati et al, 1993). Lack of available information on H. pylori infection status in our study limited us to adjust the potential confounding bias of this risk factor.…”

Section: Discussionmentioning

confidence: 92%

Association Analysis of Common Genetic Variations in MUC5AC Gene with the Risk of Non-cardia Gastric Cancer in a Chinese Population

Zhou¹,

Zhang²,

Gao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Several lines of evidence suggest that genetic variation in MUC5AC gene might contribute to the risk of gastric cancer. We conducted a case-control study to evaluate the relationship between common genetic variations in MUC5AC gene and non-cardia gastric cancer using an LD-based tagSNP approach in Baotou, north-western China. We genotyped 12 tagSNPs by TaqMan method among 288 cases with non-cardia gastric cancer and 281 normal controls. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for non-cardia gastric cancer risk in association with alleles, genotypes and haplotypes. We observed that the frequencies of rs3793964 C allele and rs11040869 A allele were significantly lower in cases than in controls. Meanwhile, minor allele homozygotes of rs3793964 and rs11040869 were significantly associated with a decreased risk of non-cardia gastric cancer when compared with their major allele homozygotes. Furthermore, a statistically significantly protective effect of rs885454 genotypes on non-cardia gastric cancer was also observed (for CT vs. CC: OR=0.581, 95%CI=0.408-0.829; for CT/TT vs. CC: OR=0.623, 95%CI=0.451-0.884). Our results indicated that some common genetic variations in the MUC5AC gene might have effects on the risk of non-cardia gastric cancer in our studied population.

show abstract

Prevalence of Helicobacter pylori infection in patients with precancerous changes and gastric cancer

Cited by 45 publications

References 0 publications

Lack of Association of Common Polymorphisms in MUC1 Gene with H. pylori Infection and Non-cardia Gastric Cancer Risk in a Chinese Population

Lack of Association of Common Polymorphisms in MUC1 Gene with H. pylori Infection and Non-cardia Gastric Cancer Risk in a Chinese Population

Gastric cancer risk in a Mexican population: Role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin‐1 and ‐10 genes

Association Analysis of Common Genetic Variations in MUC5AC Gene with the Risk of Non-cardia Gastric Cancer in a Chinese Population

Contact Info

Product

Resources

About